Results 21 to 30 of about 50,255 (242)
PLoS ONE, 2014 During embryonic development of Artemia sinica, environmental stresses induce the embryo diapause phenomenon, required to resist apoptosis and regulate cell cycle activity.
Bing Chu +9 more
doaj +1 more source
SUMO-SIM interactions regulate the activity of RGSZ2 proteins. [PDF]
PLoS ONE, 2011 The RGSZ2 gene, a regulator of G protein signaling, has been implicated in cognition, Alzheimer's disease, panic disorder, schizophrenia and several human cancers.
Javier Garzón +6 more
doaj +1 more source
Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology [PDF]
, 2017 Because protein-protein interactions underpin most biological processes, developing tools that target them to understand their function or to inform the development of therapeutics is an important task.
Adrian Whitehouse +24 more
core +2 more sources
SUMO-1 Modification of Bovine Papillomavirus E1 Protein Is Required for Intranuclear Accumulation [PDF]
Journal of Biological Chemistry, 2000 The E1 protein is a multifunctional, origin-binding helicase that is essential for replication of papillomaviruses. Recently, bovine papillomavirus E1 was shown to be post-translationally modified by the addition of the SUMO-1 polypeptide. Here we show that the site of sumoylation maps to lysine residue 514.
D, Rangasamy +3 more
openaire +2 more sources
The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
core +1 more source
The Journal of biological chemistry, 2000 Two-hybrid screening in yeast with p73alpha isolated SUMO-1 (small ubiquitin-like modifier 1), the enzyme responsible for its conjugation, Ubc-9, and a number of novel SUMO-1-interacting proteins, including thymine DNA glycosylase, PM-Scl75, PIASx, PKY, and CHD3/ZFH.
A, Minty, X, Dumont, M, Kaghad, D, Caput
openaire +2 more sources
Cellular Physiology and Biochemistry, 2017 Background: It has been reported that blocking small ubiquitin-like modifier (SUMO) conjugation by silencing SUMO gene remarkably decreased tumor growth in vivo.
Lifang Jin +4 more
doaj +1 more source
Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]
, 2018 The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti +66 more
core +3 more sources
PLoS Genetics, 2022 The sumoylation (SUMO) pathway is involved in a variety of processes during C. elegans development, such as gonadal and vulval fate specification, cell cycle progression and maintenance of chromosome structure.
Aleksandra Fergin +4 more
doaj +1 more source
The Protein Stability and Transcriptional Activity of p63α are Regulated by SUMO-1 Conjugation [PDF]
Cell Cycle, 2004 Post-translational modification of proteins by the ubiquitin-like molecule SUMO-1 regulates their stability and activity with crucial implications for many cellular processes. Here we show that p63alpha, but not p63beta and gamma, is sumoylated in vitro and in vivo at a single lysine residue, K637, in the post-SAM domain.
P. Ghioni +6 more
openaire +4 more sources