Results 41 to 50 of about 50,255 (242)

Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease

Frontiers in Pharmacology, 2014
Alzheimer's disease (AD) is a complex disorder that affects the central nervous system causing a severe neurodegeneration. This pathology affects an increasing number of people worldwide due to the overall aging of the human population.
Robert eNisticò, Robert eNisticò, Caterina eFerraina, Veronica eMarconi, Fabio eBlandini, Lucia eNegri, Jan eEgebjerg, Marco eFeligioni   +7 more
doaj   +1 more source

The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]

, 2007
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton, al-Khodairy, Allshire, Allshire, Andrews, Apionishev, Branzei, Chakrabarti, Cheng, E.A. Outwin, Ekwall, F.-X. Ogi, F.Z. Watts, Grishchuk, Ho, Ho, Hoege, Hooker, J.C.-Y. Ho, Johnson, Kagey, Kahyo, L. Gardner, L.K. Boyd, M.A.M. Trickey, McDonald, Okubo, Pichler, Potts, Reindle, Sachdev, Schmidt, Sergeant, Shayeghi, Shin, Stelter, Strahl-Bolsinger, Tanaka, Taylor, Thon, Watts, Xhemalce, Xhemalce, Zhao, Zhao   +44 more
core   +2 more sources

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source

Covalent Modification of the Werner's Syndrome Gene Product with the Ubiquitin-related Protein, SUMO-1 [PDF]

Journal of Biological Chemistry, 2000
Werner's syndrome is a potential model of accelerated human aging. The gene responsible for Werner's syndrome encodes a protein that has a helicase domain homologous to Escherichia coli RecQ. To identify binding partners that regulate the function in concert with Wrn, we screened for proteins using the yeast two-hybrid system with mouse Wrn as bait and
Y, Kawabe, M, Seki, T, Seki, W S, Wang, O, Imamura, Y, Furuichi, H, Saitoh, T, Enomoto   +7 more
openaire   +2 more sources

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]

, 2016
Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P, Hu, Q, Ke, X, Liu, Y, Meng, J, Shu, B, Wang, H, Zhang, Y, Zheng, C, Zheng, Z   +9 more
core   +1 more source

SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics

BioTechniques, 2022
Epigenetic mechanisms control chromatin accessibility and gene expression to ensure proper cell fate specification. Histone proteins are integral chromatin components, and their modification promotes gene expression regulation.
Gülkiz Baytek, Alexander Blume, Funda Gerceker Demirel, Selman Bulut, Oliver Popp, Philipp Mertins, Baris Tursun   +6 more
doaj   +1 more source

Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops. [PDF]

, 2017
Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
Ede, Christopher, Freudenthal, Bret D, Gore, Steven K, Heyer, Wolf-Dietrich, Jenkins, Shirin S, Liu, Jie, Todd Washington, M, Veaute, Xavier, Wright, William D   +8 more
core   +3 more sources

A role for SUMO modification in transcriptional repression and activation [PDF]

, 2007
Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David, Gill, Gomez-del Arco, Gostissa, Hong, I. Stancheva, Ichimura, Kirsh, Klose, Lin, Ling, Lyst, M.J. Lyst, Nathan, Nishida, Rodriguez, Shiio, Shin, Sterner, Uchimura, Verger, Yamaguchi, Yamamoto, Yang, Yang, Yang, Yang   +26 more
core   +1 more source

Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1 [PDF]

Journal of Biological Chemistry, 1999
The ubiquitin-like protein SUMO-1 is conjugated to a variety of proteins including Ran GTPase-activating protein 1 (RanGAP1), IkappaBalpha, and PML. SUMO-1-modified proteins display altered subcellular targeting and/or stability. We have purified the SUMO-1-activating enzyme from human cells and shown that it contains two subunits of 38 and 72 kDa ...
J M, Desterro, M S, Rodriguez, G D, Kemp, R T, Hay   +3 more
openaire   +2 more sources

A simple and rapid protein purification method based on cell-surface display of SUMO-fused recombinant protein and Ulp1 protease

AMB Express, 2020
The development of novel methods for highly efficient protein purification remains a research focus in the biotechnology field because conventional purification approaches, including affinity purification, gel filtration, and ion-exchange chromatography,
Xiao-Feng Zhou, Chen-Lu Zhang, Xue-Ping Gao, Wei-Long Wang, Zheng-Fen He, Feng-Ying Jiang, Yi-Lin Pang, Jiang-Hui Li, Xiao-Jun Ren, Huai-Bin Zhou, Guo-Qiang Tan, Jian-Xin Lyu, Wu Wang   +12 more
doaj   +1 more source