SUMO-1 possesses DNA binding activity
BMC Research Notes, 2010 Background Conjugation of small ubiquitin-related modifiers (SUMOs) is a frequent post-translational modification of proteins. SUMOs can also temporally associate with protein-targets via SUMO binding motifs (SBMs).
Wieruszeski Jean-Michel +3 more
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A SUMO-Dependent Protein Network Regulates Chromosome Congression During Oocyte Meiosis [PDF]
, 2017 During Caenorhabditis elegans oocyte meiosis, a multi-protein ring complex (RC) localised between homologous chromosomes, promotes chromosome congression through the action of the chromokinesin KLP-19. While some RC components are known, the mechanism of
Gartner, Anton +5 more
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Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications [PDF]
, 2014 We have designed a novel non-antibody scaffold protein, termed Adhiron, based on a phytocystatin consensus sequence. The Adhiron scaffold shows high thermal stability (Tm ca. 101°C), and is expressed well in Escherichia coli. We have determined the X-ray
Afonine +61 more
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RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]
, 2020 Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe +4 more
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Regulation of the Expression of DAPK1 by SUMO Pathway
Biomolecules, 2019 Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological effect of multiple natural biomolecules such as IFN-γ, TNF-α, curcumin, etc.
Qingshui Wang +13 more
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Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. [PDF]
, 2017 Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
Ahmad, Alla S +8 more
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Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3 [PDF]
Journal of Biological Chemistry, 2000 Post-translational modification marked by the covalent attachment of the ubiquitin-like protein SUMO-1/SMT3C has been implicated in a wide variety of cellular processes. Recently, two cDNAs encoding proteins related to SUMO-1 have been identified in human and mouse. The functions and regulation of these proteins, known as SUMO-2/SMT3A and SUMO-3/SMT3B,
H, Saitoh, J, Hinchey
openaire +2 more sources
SUMO chain formation is required for response to replication arrest in S. pombe.
PLoS ONE, 2009 SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
Andrew Skilton +4 more
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PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans
eLife, 2021 Germlines shape and balance heredity, integrating and regulating information from both parental and foreign sources. Insights into how germlines handle information have come from the study of factors that specify or maintain the germline fate.
Heesun Kim +7 more
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SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer [PDF]
, 2019 BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC).
Díaz Moreno, Irene +4 more
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