Results 41 to 50 of about 291,935 (374)
SUMO Wrestles with Recombination [PDF]
Biomolecules, 2012 DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs.
Lumir Krejci +2 more
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SUMO: regulating the regulator.
Cell division, 2006 Post-translational modifiers of the SUMO (Small Ubiquitin-related Modifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review
Bossis, G., Melchior, F.
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Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3 [PDF]
Journal of Biological Chemistry, 2006 SUMOylation is a reversible process regulated by a family of sentrin/SUMO-specific proteases (SENPs). Of the six SENP family members, except for SENP1 and SENP2, the substrate specificities of the rest of SENPs are not well defined. Here, we have described SENP5, which has restricted substrate specificity.
Limin Gong, Edward T.H. Yeh
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Heliyon, 2023 Information and communication technology graduates are among the highly skilled, paid, and perceived as capable and credible professionals worldwide. This has resonated in significant growth in the number of students pursuing careers in ICT at various ...
Dorris Zayzay Sumo +2 more
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Biotechnology & Biotechnological Equipment, 2019 The present study investigated the role and mechanism of SUMO2/3 in the protection of vascular endothelial cells by propofol. An ischemia-reperfusion (I/R) injury model of human umbilical vein endothelial cells (HUVECs) was constructed.
Peng Li +3 more
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Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases [PDF]
Angewandte Chemie, 2018 AbstractSUMO is a post‐translational modifier critical for cell cycle progression and genome stability that plays a role in tumorigenesis, thus rendering SUMO‐specific enzymes potential pharmacological targets. However, the systematic generation of tools for the activity profiling of SUMO‐specific enzymes has proven challenging.
Huib Ovaa +18 more
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Molecular & Cellular Oncology, 2022 RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation.
Younghoon Kee, Jung-Hee Lee, Ho Jin You
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Sequential sampling strategy for the modeling of parameterized microwave and RF components [PDF]
, 2011 Accurate modeling of parameterized microwave and RF components often requires a large number of full-wave electromagnetic simulations. In order to reduce the overall simulation cost, a sequential sampling algorithm is proposed that selects a sparse set ...
Crombecq, Karel +3 more
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Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility
Nature Communications, 2020 The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways. Increasing evidence shows that PIAS1 is overexpressed in various human malignancies, including prostate and lung cancers.
Chongyang Li +7 more
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2020 The Sgs1 helicase and Top3-Rmi1 decatenase form a complex that affects homologous recombination outcomes during the mitotic cell cycle and during meiosis.
Matan Cohen, Michael Lichten
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