Results 101 to 110 of about 53,155 (238)

The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]

, 2017
Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna, Ibba, Gabriele, Palamara, Anna T., Pietropaolo, Valeria, White, Martyn K., Wollebo, Hassen, Wollebo|   +6 more
core   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells [PDF]

, 2017
Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation ...
Cippitelli, M, De Turris, V, Fionda, C, Gismondi, A, Lecce, M, Molfetta, R°, Paolini, R, Petrucci, Mt, Quatrini, L, Ricciardi, Mr, Santoni, A, Stabile, H, Zitti, B°, °these Authors Contributed Equally To The, Work   +13 more
core   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

Predicting sumoylation sites using support vector machines based on various sequence features, conformational flexibility and disorder [PDF]

, 2014
Background Sumoylation, which is a reversible and dynamic post-translational modification, is one of the vital processes in a cell. Before a protein matures to perform its function, sumoylation may alter its localization, interactions, and possibly ...
Sezerman, Ugur, Sezerman, Uğur, Yavuz, Ahmet Sinan   +2 more
core   +3 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence

Journal of Fungi, 2020
The small ubiquitin-related modifier (SUMO) protein is an important component of the post-translational protein modification systems in eukaryotic cells.
Mahima Sagar Sahu, Sandip Patra, Kundan Kumar, Rupinder Kaur   +3 more
doaj   +1 more source

Detection of Sumoylated Proteins [PDF]

, 2005
Small ubiquitin-related modifier (SUMO) is an ubiquitin-like protein that is covalently attached to a variety of target proteins. Unlike ubiquitination, sumoylation does not target proteins for proteolytic breakdown, but is involved in regulation of protein function, nuclear targeting, and the formation of subcellular structures.
Roland S, Hilgarth, Kevin D, Sarge
openaire   +2 more sources

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. [PDF]

, 2016
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge's disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment ...
Appenzeller, Otto, Azad, Priti, Bafna, Vineet, Cabrales, Pedro J, Haddad, Gabriel G, Hsiao, Yu Hsin, Poulsen, Orit, Ronen, Roy, Zhao, Huiwen W, Zhou, Dan   +9 more
core  

Sumoylation of eIF4A2 affects stress granule formation [PDF]

, 2016
Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis.
Anderson, Anderson, Balagopal, Bellsolell, Bish, Blomster, Bruderer, Buchan, Chan, Coldwell, Dang, Enserink, Finkbeiner, Galicia-Vázquez, Geiss-Friedlander, Girdwood, Guertin, Hannoun, Harlow, Ho, Jackson, Jentsch, Johnson, Jongjitwimol, Kedersha, Kwon, Laplante, Lindqvist, Lu, Marintchev, Matafora, Matic, Matsuo, Mazroui, Meijer, Mokas, Morley, Morley, Muller, Nie, Nielsen, Oberer, Shevchenko, Sonenberg, Spriggs, Ulrich, Vertegaal, Waris, Watts, Watts, Watts, Xu, Yoder-Hill   +52 more
core   +3 more sources