Sumoylation and Nuclear Translocation of S100A4 Regulate IL-1β-mediated Production of Matrix Metalloproteinase-13 [PDF]
, 2010 Keally J. Miranda +2 more
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Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis
BioEssays, Volume 48, Issue 1, January 2026.The synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Ariel L. Gold, Yumi Kim
wiley +1 more source
Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids
Biotechnology Journal, Volume 21, Issue 1, January 2026.Graphical Abstract and Lay Summary Recombinant adeno‐associated viruses (AAV) are important in gene therapy but their production may be impaired by non‐optimized gene design. In this study, the authors demonstrate that production was best when the AAV replicase gene was in a wild‐type configuration while the complexity of other genetic elements could ...
Marco T. Radukic +10 more
wiley +1 more source
Acetylation and sumoylation control STAT5 activation antagonistically [PDF]
, 2012 Oliver H. Krämer, Richard Moriggl
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Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment
Cancer Medicine, Volume 15, Issue 1, January 2026.Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang +5 more
wiley +1 more source
A role for SUMOylation in snoRNP biogenesis revealed by quantitative proteomics [PDF]
, 2011 Belinda J. Westman, Angus I. Lamond
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Supplemental Materials and Methods from Chemotherapeutic Sensitivity of Testicular Germ Cell Tumors Under Hypoxic Conditions Is Negatively Regulated by SENP1-Controlled Sumoylation of OCT4 [PDF]
, 2023 Yu-Chih Wu +7 more
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Dynamin Interacts with Members of the Sumoylation Machinery [PDF]
, 2004 Ram Kumar Mishra +5 more
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Aging Cell, Volume 25, Issue 1, January 2026.Our research firstly indicated that age‐dependent upregulation of tissue kallikrein‐related peptidase 8 (KLK8) induces endothelial senescence through modulating the fibronectin‐FAK‐Akt‐PARP1/2 axis, thereby increasing the vulnerability of aged mice to low‐tidal‐volume ventilator‐induced lung injury (VILI).
Di Liu +7 more
wiley +1 more source
PRKN‐Mediated Ubiquitin‐Proteasome Degradation of METTL3 Promotes Cellular Senescence
Aging Cell, Volume 25, Issue 1, January 2026.Schematic diagram of model for PRKN mediate METTL3 proteasome degradation promoting cellular senescence. The left panel shows a high abundance of METTL3 expression in young cells. METTL3 mediates m6A modification on TRF2 and POT1 mRNA, leading to their high expression and maintaining telomere stability.
Liping Chen +14 more
wiley +1 more source