Results 111 to 120 of about 37,758 (275)

Site-specific characterization of endogenous SUMOylation across species and organs

Nature Communications, 2018
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications that play crucial roles in most cellular processes. While methods exist to study exogenous SUMOylation, large-scale characterization of endogenous SUMO2/3 has remained ...
I. Hendriks, David Lyon, D. Su, Niels H. Skotte, J. A. Daniel, L. Jensen, M. L. Nielsen   +6 more
semanticscholar   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

SUMOylation regulates AKT1 activity [PDF]

Oncogene, 2014
Serine threonine kinase AKT has a central role in the cell, controlling survival, proliferation, metabolism and angiogenesis. Deregulation of its activity underlies a wide range of pathological situations, including cancer. Here we show that AKT is post-translationally modified by the small ubiquitin-like modifier (SUMO) protein. Interestingly, neither
Cruz-Herrera, Carlos F. De La, Campagna, Michela, Lang, V., González-Santamaría, J. del Carmen, Marcos-Villar, Laura, Rodríguez, M. S., Vidal, Anxo, Collado, Manuel, Rivas, Carmen   +8 more
openaire   +4 more sources

The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review

Stem Cells International, 2020
Malignant tumors still pose serious threats to human health due to their high morbidity and mortality. Recurrence and metastasis are the most important factors affecting patient prognosis.
Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang   +5 more
doaj   +1 more source

Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.

Cell Reports, 2020
Expanded CAG repeats form stem-loop secondary structures that lead to fork stalling and collapse. Previous work has shown that these collapsed forks relocalize to nuclear pore complexes (NPCs) in late S phase in a manner dependent on replication, the ...
J. Whalen, Nalini Dhingra, Lei Wei, Xiaolan Zhao, C. Freudenreich   +4 more
semanticscholar   +1 more source

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

SUMOylation promotes protective responses to DNA‐protein crosslinks

EMBO Journal, 2019
DNA‐protein crosslinks (DPCs) are highly cytotoxic lesions that obstruct essential DNA transactions and whose resolution is critical for cell and organismal fitness.
Nikoline Borgermann, Leena Ackermann, P. Schwertman, I. Hendriks, K. Thijssen, Julio C Y Liu, H. Lans, M. L. Nielsen, Niels Mailand   +8 more
semanticscholar   +1 more source

SUMOylation Stabilizes the Transcription Factor DREB2A to Improve Plant Thermotolerance1

Plant Physiology, 2020
SUMOylation increases the protein stability of DREB2A, a key transcription factor in the response to heat stress in plant cells. Heat stress (HS) has serious effects on plant development, resulting in heavy agricultural losses.
Feige Wang, Yiyang Liu, Yaqiao Shi, Danlu Han, Yuanyuan Wu, Weixian Ye, Huanling Yang, Guowei Li, Feng Cui, S. Wan, Jianbin Lai, Chengwei Yang   +11 more
semanticscholar   +1 more source

Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition

BioEssays, EarlyView.
Annexins are an important protein family traditionally well known to bind to phospholipids and to interact with various proteins in a calcium dependent way. More recently, it has been established that a feature common to the family is also to bind to RNA having a role in translation. In bies70019 article, Vedeler et al.
Anni Vedeler, Gian Gaetano Tartaglia, Annalisa Pastore   +2 more
wiley   +1 more source

Using glycyrrhizic acid to target sumoylation processes during Epstein-Barr virus latency.

PLoS ONE, 2019
Cellular sumoylation processes are proposed targets for anti-viral and anti-cancer therapies. We reported that Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) dysregulates cellular sumoylation processes, contributing to its oncogenic potential ...
Gretchen L Bentz, Angela J Lowrey, Dustin C Horne, Vy Nguyen, Austin R Satterfield, Tabithia D Ross, Abigail E Harrod, Olga N Uchakina, Robert J McKallip   +8 more
doaj   +1 more source