Results 31 to 40 of about 53,155 (238)
Analysis of PTP1B sumoylation [PDF]
Methods, 2014 Signaling enzymes are typically regulated by a variety of post-translational modifications. One such enzyme, protein tyrosine phosphatase (PTP) 1B, which plays an important role in metabolic and growth signaling, has recently been shown to be inhibited by posttranslational modifications by ubiquitin-related proteins of the SUMO family.
Sayanti, Saha, Jonathan, Chernoff
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The C-terminus of p63 contains multiple regulatory elements with different functions [PDF]
, 2010 The transcription factor p63 is expressed as at least six different isoforms, of which two have been assigned critical biological roles within ectodermal development and skin stem cell biology on the one hand and supervision of the genetic stability of ...
Straub, Wesley E. +8 more
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SUMOylation and De-SUMOylation: Wrestling with Life's Processes [PDF]
Journal of Biological Chemistry, 2009 The small ubiquitin-like modifier (SUMO) is a ubiquitin-like protein that covalently modifies a large number of cellular proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization. SUMOylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and ligating (E3) enzymes and
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A role for SUMO modification in transcriptional repression and activation [PDF]
, 2007 Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David +26 more
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Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. [PDF]
PLoS ONE, 2009 Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells.
Yuqi Wang +3 more
doaj +1 more source
Biology Open, 2019 During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated degradation of maternal proteins plays a role
Chika Higuchi +4 more
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SUMOylation and bacterial pathogens [PDF]
Virulence, 2010 During infection, bacterial pathogens interfere with many different post-translational modifications of the host cell to promote their own survival and replication. By stimulating or counteracting host post-translational modifications, these pathogens may control locally and specifically the fate and function of host factors critical for the infection ...
David, Ribet, Pascale, Cossart
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Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]
, 2013 The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer +64 more
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eLife, 2015 SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that
Miyuki Suzawa +12 more
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Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]
PLoS ONE, 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek +6 more
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