Results 31 to 40 of about 37,758 (275)
PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence
PLoS Pathogens, 2022 Host defense systems employ posttranslational modifications to protect against invading pathogens. Here, we found that protein inhibitor of activated STAT 1 (PIAS1) interacts with the nucleoprotein (NP), polymerase basic protein 1 (PB1), and polymerase ...
Guangwen Wang +16 more
semanticscholar +1 more source
Journal of Clinical Investigation, 2021 SUMOylation emerged as the inducer for the sorting of bioactive molecules into extracellular vesicles (EVs) triggering lymphangiogenesis, further driving tumor lymph node (LN) metastasis, but the precise mechanisms remain largely unclear.
Changhao Chen +11 more
semanticscholar +1 more source
PML, SUMOylation, and Senescence [PDF]
Frontiers in Oncology, 2013 Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues.
Hugues eDe Thé +10 more
openaire +4 more sources
Frontiers in Cell and Developmental Biology, 2022 Ubiquitination and SUMOylation, which are posttranslational modifications, play prominent roles in regulating both protein expression and function in cells, as well as various cellular signal transduction pathways. Metabolic reprogramming often occurs in
Shunqin Zhu +5 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 Background SUMOylation is an important component of post-translational protein modifications (PTMs), and bladder cancer (BCa) is the ninth most common cancer around the world.
Q. Xia +10 more
semanticscholar +1 more source
Analysis of PTP1B sumoylation [PDF]
Methods, 2014 Signaling enzymes are typically regulated by a variety of post-translational modifications. One such enzyme, protein tyrosine phosphatase (PTP) 1B, which plays an important role in metabolic and growth signaling, has recently been shown to be inhibited by posttranslational modifications by ubiquitin-related proteins of the SUMO family.
Sayanti Saha, Jonathan Chernoff
openaire +3 more sources
Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infection. [PDF]
PLoS ONE, 2014 Post-translational modification of proteins by members of the small ubiquitin-like modifier (SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and also interact with the cellular SUMOylation system.
Eui Tae Kim +5 more
doaj +1 more source
Natural Products Against Renal Fibrosis via Modulation of SUMOylation
Frontiers in Pharmacology, 2022 Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development ...
Peng Liu +5 more
doaj +1 more source
Nature Communications, 2022 DNA end resection is delicately regulated through various types of post-translational modifications to initiate homologous recombination, but the involvement of SUMOylation in this process remains incompletely understood.
Zhang Tao +5 more
semanticscholar +1 more source
SUMOylation in Drosophila Development [PDF]
Biomolecules, 2012 Small ubiquitin-related modifier (SUMO), an ~90 amino acid ubiquitin-like protein, is highly conserved throughout the eukaryotic domain. Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins. In contrast to ubiquitin, SUMO does not have a direct role in targeting proteins for proteasomal degradation ...
Smith, Matthew +2 more
openaire +6 more sources