Results 31 to 40 of about 31,613 (261)
SUMOylation and bacterial pathogens [PDF]
Virulence, 2010 During infection, bacterial pathogens interfere with many different post-translational modifications of the host cell to promote their own survival and replication. By stimulating or counteracting host post-translational modifications, these pathogens may control locally and specifically the fate and function of host factors critical for the infection ...
David Ribet, Pascale Cossart
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Biology Open, 2019 During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated degradation of maternal proteins plays a role
Chika Higuchi +4 more
doaj +1 more source
Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. [PDF]
PLoS ONE, 2009 Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells.
Yuqi Wang +3 more
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eLife, 2015 SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that
Miyuki Suzawa +12 more
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Extranuclear SUMOylation in Neurons [PDF]
Trends in Neurosciences, 2018 Post-translational modification of substrate proteins by SUMO conjugation regulates a diverse array of cellular processes. While predominantly a nuclear protein modification, there is a growing appreciation that SUMOylation of proteins outside the nucleus plays direct roles in controlling synaptic transmission, neuronal excitability, and adaptive ...
Jeremy M. Henley +2 more
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mRNA expression analysis of the SUMO pathway genes in the adult mouse retina
Biology Open, 2015 Sumoylation is a reversible post-translational modification that regulates different cellular processes by conjugation/deconjugation of SUMO moieties to target proteins.
Víctor Abad-Morales +3 more
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Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]
PLoS ONE, 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek +6 more
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Detection of Sumoylated Proteins [PDF]
, 2005 Small ubiquitin-related modifier (SUMO) is an ubiquitin-like protein that is covalently attached to a variety of target proteins. Unlike ubiquitination, sumoylation does not target proteins for proteolytic breakdown, but is involved in regulation of protein function, nuclear targeting, and the formation of subcellular structures.
Kevin D. Sarge, Ok Kyong Park-Sarge
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SUMOylation in the control of cholesterol homeostasis [PDF]
Open Biology, 2020 SUMOylation—protein modification by the small ubiquitin-related modifier (SUMO)—affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the maintenance of metabolic homeostasis.
Orhi Barroso-Gomila +7 more
openaire +5 more sources
Protein SUMOylation modification and its associations with disease [PDF]
Open Biology, 2017 SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis.
Yanfang Yang +8 more
doaj +1 more source