Results 41 to 50 of about 37,758 (275)
Sumoylation at the Host-Pathogen Interface
Biomolecules, 2012 Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity.
Van G. Wilson
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Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription [PDF]
Endocrinology and Metabolism, 2015 BackgroundHes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system.
Jiwon Lee +3 more
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Sumoylation on its 25th Anniversary: Mechanisms, Pathology and Emerging Concepts.
The FEBS Journal, 2020 Sumoylation is an essential post-translational modification intimately involved in a diverse range of eukaryotic cellular mechanisms. SUMO protein isoforms can be reversibly linked to lysine residues that reside within specific motifs on thousands of ...
Arda B Celen, Umut Şahin
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Science Translational Medicine, 2021 Description TAK-981, a first-in-class small-molecule SUMOylation inhibitor, activates type I interferon signaling to promote antitumor immune responses in mice.
E. Lightcap +29 more
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Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
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Science Advances, 2021 SUMOylation of annexin-A1 promotes an anti-inflammatory microglial phenotype and protects against cerebral ischemic injury. Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying ...
Xing Li +9 more
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International Journal of Molecular Sciences, 2022 Post-translational modifications of proteins ensure optimized cellular processes, including proteostasis, regulated signaling, cell survival, and stress adaptation to maintain a balanced homeostatic state.
Nicole Pellegrino +10 more
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Functional, pathogenic, and pharmacological roles of protein folding intermediates
Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023 Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
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eLife, 2015 SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that
Miyuki Suzawa +12 more
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SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. [PDF]
PLoS ONE, 2012 Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog
Yongyan Wu +10 more
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