Results 41 to 50 of about 53,155 (238)
The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
core +1 more source
Host SUMOylation in bacterial infections and immune defense mechanisms
Frontiers in MicrobiologySUMOylation, the covalent attachment of small ubiquitin-like modifier proteins (SUMO) to lysine residues of target substrates, has emerged as a crucial post-translational modification regulating various cellular processes.
Yuhua Xu +11 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2019 Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS).
Allison R. Peterson, Devin K. Binder
doaj +1 more source
Protein SUMOylation modification and its associations with disease [PDF]
Open Biology, 2017 SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis.
Yanfang Yang +8 more
doaj +1 more source
mRNA expression analysis of the SUMO pathway genes in the adult mouse retina
Biology Open, 2015 Sumoylation is a reversible post-translational modification that regulates different cellular processes by conjugation/deconjugation of SUMO moieties to target proteins.
Víctor Abad-Morales +3 more
doaj +1 more source
PLoS Genetics, 2021 Transcription-related proteins are frequently identified as targets of sumoylation, including multiple subunits of the RNA polymerase II (RNAPII) general transcription factors (GTFs).
Mohammad S Baig +12 more
doaj +1 more source
A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]
, 2017 Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho +5 more
core +3 more sources
SUMOylation and NEDDylation in kidney diseases
Experimental and Molecular PathologyKidney disease poses a serious threat to human health and life, while the lack of specific therapeutic targets hinders the treatment of kidney disease.
Zi-Han Chen +6 more
doaj +1 more source
NF-κB repression by PIAS3 mediated RelA SUMOylation. [PDF]
PLoS ONE, 2012 Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ...
Yuangang Liu +3 more
doaj +1 more source
SUMOylation regulates AKT1 activity [PDF]
Oncogene, 2014 Serine threonine kinase AKT has a central role in the cell, controlling survival, proliferation, metabolism and angiogenesis. Deregulation of its activity underlies a wide range of pathological situations, including cancer. Here we show that AKT is post-translationally modified by the small ubiquitin-like modifier (SUMO) protein. Interestingly, neither
Cruz-Herrera, C.F. +8 more
openaire +3 more sources