Results 41 to 50 of about 31,613 (261)
PLoS Genetics, 2021 Transcription-related proteins are frequently identified as targets of sumoylation, including multiple subunits of the RNA polymerase II (RNAPII) general transcription factors (GTFs).
Mohammad S Baig +12 more
doaj +1 more source
NF-κB repression by PIAS3 mediated RelA SUMOylation. [PDF]
PLoS ONE, 2012 Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ...
Yuangang Liu +3 more
doaj +1 more source
SUMOylation and cell signalling
Biotechnology Journal, 2009 AbstractSUMOylation is a highly transient post‐translational protein modification. Attachment of SUMO to target proteins occurs via a number of specific activating and ligating enzymes that form the SUMO‐substrate complex, and other SUMO‐specific proteases that cleave the covalent bond, thus leaving both SUMO and target protein free for the next round ...
Nektarios Tavernarakis +1 more
openaire +4 more sources
Frontiers in Molecular Neuroscience, 2019 Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS).
Allison R. Peterson, Devin K. Binder
doaj +1 more source
Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. [PDF]
PLoS ONE, 2012 The forkhead box protein A2 (FOXA2) is an important regulator of glucose and lipid metabolism and organismal energy balance. Little is known about how FOXA2 protein expression and activity are regulated by post-translational modifications.
Narasimhaswamy S Belaguli +3 more
doaj +1 more source
Sumoylation in Physiology, Pathology and Therapy
Cells, 2022 Sumoylation is an essential post-translational modification that has evolved to regulate intricate networks within emerging complexities of eukaryotic cells.
Umut Sahin +2 more
doaj +1 more source
Cells, 2023 Diabetic peripheral neuropathy (DPN) is the prevalent type of peripheral neuropathy; it primarily impacts extremity nerves. Its multifaceted nature makes the molecular mechanisms of diabetic neuropathy intricate and incompletely elucidated. Several types
Nicolas Mandel +4 more
doaj +1 more source
SUMOylation of claudin‐2 [PDF]
Annals of the New York Academy of Sciences, 2012 The C‐terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two‐hybrid screen with the tail of human claudin‐2 against a human kidney cDNA library and identified interactions with the PDZ3 domain of ZO‐2 as well as ubiquitin‐conjugating enzyme E2I (SUMO ligase‐1) and E3 ...
Laura L. Mitic +2 more
openaire +3 more sources
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
SUMOylation of ZEB1 Modulates PANoptosis in Burn-Induced Early Acute Kidney Injury. [PDF]
J Cell Mol MedABSTRACT Burn‐induced acute kidney injury (AKI) involves inflammatory programmed cell death pathways, including PANoptosis. This study investigated how SUMOylation of the transcription factor ZEB1 regulates PANoptosis in early burn‐induced AKI. Human AKI datasets were analyzed for ZEB1 expression and correlation with PANoptosis/SUMOylation genes. A rat
Zhang J +6 more
europepmc +2 more sources