Results 81 to 90 of about 32,358 (200)

SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1 ^Tpp1 to modulate shelterin–Stn1 interaction in fission yeast [PDF]

, 2014
Keisuke Miyagawa, Ross S. Low, Venny Santosa, Hiroki Tsuji, Bettina A. Moser, Shiho Fujisawa, Jennifer L. Harland, Olga N. Raguimova, Andrew Go, Masaru Ueno, Akihisa Matsuyama, Minoru Yoshida, Toru Nakamura, Katsunori Tanaka   +13 more
openalex   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Psoriasis‐like inflammation induces structural and functional changes in mitochondria

The FEBS Journal, EarlyView.
Psoriasis‐like inflammation, induced by IL‐17, IL‐22, and TNF‐α in keratinocytes and fibroblasts, alters mitochondrial functions, suppressing respiration and increasing mitochondrial ROS production. It also triggers mitochondrial fragmentation, swelling, and cristae disassembly, alongside enhanced secretion of proinflammatory mediators driven by ...
Gabrielė Kulkovienė, Martyna Uldukytė, Sofiya Haluts, Milda Kairytė, Jonas Šoliūnas, Viktorija Šalčiūtė, Rūta Inčiūraitė, Jurgita Skiecevičienė, Monika Iešmantaitė, Ramunė Morkūnienė, Aistė Jekabsone   +10 more
wiley   +1 more source

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport [PDF]

, 2014
Sokrates Stein, Maaike H. Oosterveer, Chikage Mataki, Pan Xu, Vera Lemos, Rick Havinga, Claudia Dittner, Dongryeol Ryu, Keir J. Menzies, Xu Wang, Alessia Perino, Sander M. Houten, Frauke Melchior, Kristina Schoonjans   +13 more
openalex   +1 more source

WNT-responsive SUMOylation of ZIC5 promotes murine neural crest cell development, having multiple effects on transcription [PDF]

, 2021
Radiya G. Ali, Helen M. Bellchambers, Nick Warr, Jehangir N. Ahmed, Kristen S. Barratt, Kieran Neill, Koula E. M. Diamand, Ruth M. Arkell   +7 more
openalex   +1 more source

Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Given the rarity and aggressive nature of osteosarcomas (OS) in the oral and maxillofacial region, understanding their molecular alterations is essential to improve diagnosis, prognosis, and guide targeted therapies. This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the
Iara Vieira Ferreira, Reydson Alcides de Lima‐Souza, Moisés Willian Aparecido Gonçalves, Carlos Takahiro Chone, Arthur Antolini‐Tavares, Albina Altemani, Fernanda Viviane Mariano   +6 more
wiley   +1 more source

PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

, 2021
Heesun Kim, Yue‐He Ding, Shan Lu, Mei-Qing Zuo, Wendy Tan, Darryl Conte, Meng‐Qiu Dong, Craig C. Mello   +7 more
openalex   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Editor's evaluation: Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

, 2021
Hening Lin
openalex   +1 more source

Engineering Marker‐Free Lettuce Chloroplast Genome to Express Functional Glucagon‐Like Peptide‐1 Receptor Agonists Exenatide and Lixisenatide

Plant Biotechnology Journal, EarlyView.
Engineering of marker‐free lettuce chloroplast genome to express CTB‐Exenatide and CTB‐Lixisenatide for oral delivery. Upper panel: Chemically synthesised exenatide or lixisenatide require expensive production, purification, refrigeration and invasive delivery methods.
Rahul Singh, Henry Daniell
wiley   +1 more source