Results 81 to 90 of about 31,613 (261)

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Novel post-translational modifications in bone remodeling: potential therapeutic strategies for osteoporosis

European Cells & Materials
Osteoblast-induced bone formation and osteoclast-mediated bone resorption coordinate the balance of bone remodeling. However, the exact mechanisms underlying bone remodeling remain unknown.
ZJ Pan, HH Liu, LY Liu, QZ Wang, J Pan
doaj   +1 more source

Plant defense strategies: The dual armor of disease resistance and tolerance

New Plant Protection, EarlyView.
Plants employ dual strategies against pathogens: Resistance limits invasion via immune responses, whereas tolerance mitigates damage to sustain growth—together enhancing survival under infections. Abstract Pathogen infections pose a significant threat to plant health, global food security, and ecosystems.
Zhijuan Tang, Shaosong Shi, Xinyu Du, Guoyong Xu   +3 more
wiley   +1 more source

SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence

Journal of Fungi, 2020
The small ubiquitin-related modifier (SUMO) protein is an important component of the post-translational protein modification systems in eukaryotic cells.
Mahima Sagar Sahu, Sandip Patra, Kundan Kumar, Rupinder Kaur   +3 more
doaj   +1 more source

Tollip Is a Mediator of Protein Sumoylation

PLoS ONE, 2009
Tollip is an interactor of the interleukin-1 receptor involved in its activation. The endosomal turnover of ubiquitylated IL-1RI is also controlled by Tollip. Furthermore, together with Tom1, Tollip has a general role in endosomal protein traffic. This work shows that Tollip is involved in the sumoylation process.
Ciarrocchi A., D'Angelo R., Cordiglieri C., Rispoli A., Santi S., Riccio M., Carone S., MANCIA, Annalaura, Paci S., Cipollini E., Ambrosetti D, Melli M.   +11 more
openaire   +7 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Using glycyrrhizic acid to target sumoylation processes during Epstein-Barr virus latency.

PLoS ONE, 2019
Cellular sumoylation processes are proposed targets for anti-viral and anti-cancer therapies. We reported that Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) dysregulates cellular sumoylation processes, contributing to its oncogenic potential ...
Gretchen L Bentz, Angela J Lowrey, Dustin C Horne, Vy Nguyen, Austin R Satterfield, Tabithia D Ross, Abigail E Harrod, Olga N Uchakina, Robert J McKallip   +8 more
doaj   +1 more source

Solo or in Concert: SUMOylation in Pathogenic Fungi [PDF]

The Plant Pathology Journal
SUMOylation plays a pivotal role in DNA replication and repair, transcriptional stability, and stress response. Although SUMOylation is a conserved post-translational modification (PTM) in eukaryotes, the number, type, and function of SUMOylation ...
You-Jin Lim, Yong-Hwan Lee
doaj   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications

PROTEOMICS, EarlyView.
ABSTRACT Protein function is dynamically modulated by post‐translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. It is well known that many PTMs have an effect on protein function and cellular processes, and they should be studied not in isolation, but in the
Julian Müller, Bernhard Kuster, Matthew The   +2 more
wiley   +1 more source