Results 81 to 90 of about 12,609 (207)

Enhanced susceptibility to superantigen‐associated streptococcal sepsis in human leukocyte antigen–DQ transgenic mice

, 2001
Bacterial superantigens are believed to cause septic shock, although, because of the lack of superantigen-sensitive infection models, proof that superantigenicity underlies shock pathogenesis is lacking. This work demonstrates a clear superantigen effect
Cohen, Jonathan, Dewchand, Hamlata, Unnikrishnan, Meera, Krausz, Thomas, Altmann, Daniel M., Van Noorden, Susan, Sriskandan, Shiranee   +6 more
core   +1 more source

Intact Staphylococcus Enterotoxin SEB from Culture Supernatant Detected by MALDI-TOF Mass Spectrometry

Toxins, 2019
Routine identification of pathogens by MALDI-TOF MS (matrix-assisted laser desorption ionisation time-of-flight mass spectrometry) is based on the fingerprint of intracellular proteins.
Jenna Tonacini, Dario Stephan, Guido Vogel, Marc-André Avondet, Franka Kalman, Julien Crovadore, François Lefort, Bruno Schnyder   +7 more
doaj   +1 more source

Severe generalized pustular psoriasis complicated with staphylococcal toxic shock syndrome treated with spesolimab and antibiotics

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Spyridon Gkalpakiotis, Jan Hugo, Natalie Michalik, Robert Zajicek, Cecilie Stonova, Bohumil Bakalar   +5 more
wiley   +1 more source

Constitutional symptoms and response to Penicillin G in erysipelas and cellulitis – a monocentric, retrospective, explorative study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 746-754, June 2026.
Summary Background: Erysipelas, caused by streptococci, should be treated with penicillin, while uncomplicated cellulitis (phlegmon), often caused by Staphylococcus aureus, requires penicillinase‐resistant beta‐lactam antibiotics, which have a higher risk of adverse effects. Distinguishing between these infections is important.
Helena Schieffers, Cord Sunderkötter
wiley   +1 more source

Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization

Toxins, 2015
Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system activation.
Stacey X. Xu, Katherine J. Kasper, Joseph J. Zeppa, John K. McCormick   +3 more
doaj   +1 more source

Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1.

, 1994
Superantigens stimulate T cells bearing particular T-cell receptor V beta sequences, so they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding of superantigens to class II major histocompatibility complex (MHC ...
Tranter, HS, Jones, Edith, Harlos, K, Jones, EY, Passalacqua, EF, Acharya, KR, Brehm, RD, Stuart, David, Stuart, DI   +8 more
core   +1 more source

Enhanced and prolonged efficacy of superantigen-induced cytotoxic T lymphocyte activity by interleukin-2 in vivo

, 1995
The bacterial superantigen, staphylococcal enterotoxin A (SEA) activates T cells with high frequency and directs them to lyse MHC-class-II-expressing cells in superantigen-dependent cell-mediated cytotoxicity (SDCC).
Mikael Dohlsten, Dohlsten, M, Terje Kalland, Hans Belfrage, Belfrage, Hans, Gunnar Hedlund, Kalland, T, Hedlund, G   +7 more
core   +2 more sources

The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes

, 1996
Several immune-mediated dermatoses including psoriasis and atopic dermatitis can be exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from skin lesions of these dermatoses. Consistent with superantigen effects, skewed T
Munk, M. E., Kaufmann, S. H., Boehncke, Wolf-Henning, Sterry, Wolfram, Zollner, Thomas Matthias, Keller, T., Duijvestijn, A. M., Nuber, V., Kaufmann, Roland   +8 more
core   +1 more source

The immunomodulatory function of staphylococcal superantigen on oral tolerance

, 2010
Exposure to soluble proteins via the gut gives rise to systemic tolerance, a phenomenon called oral tolerance. Failure of oral tolerance results in allergy, a disease that has increased during the last decades in Western industrialized countries.
Stern, Anna
core  

Mouse Mammary Tumor Virus Superantigen Expression Is Reduced by Glucocorticoid Treatment

, 2000
Expression of mouse mammary tumor virus (MMTV)-encoded superantigens in B lymphocytes are required for viral transmission and pathogenesis. Due to problems with detection and quantification of the superantigen protein, most reports about the mechanism of
Reuss, Frank U., Tovar Sepúlveda, Verónica A., Coffin, John M., Berdel, Bianca   +3 more
core   +1 more source