Results 31 to 40 of about 315,385 (314)

Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity

Toxics, 2017
Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute ...
Clare Pace, Ruben Dagda, Jeff Angermann
doaj   +1 more source

Anti-Tumour Promoting Activity and Antioxidant Properties of Girinimbine Isolated from the Stem Bark of<em> Murraya koenigii </em>S.

Molecules, 2012
Girinimbine, a carbazole alkaloid isolated from the stem bark of <em>Murraya koenigii </em>was tested for the<em> in vitro</em> anti-tumour promoting and antioxidant activities.
Yih Yih Kok, Lim Yang Mooi, Kartini Ahmad, Mohd Aspollah Sukari, Nashriyah Mat, Mawardi Rahmani, Abdul Manaf Ali   +6 more
doaj   +1 more source

Role of Protons in Superoxide Reduction by a Superoxide Reductase Analogue [PDF]

Inorganic Chemistry, 2005
Superoxide reduction by thiolate-ligated [FeII(SMe2N4(tren))]+ (1) involves two proton-dependent steps and a single peroxide intermediate, [FeIII(SMe2N4(tren))(OOH)]+ (2). An external proton donor is required, ruling out mechanisms involving H+ or H-atom abstraction from the ligand N-H.
Julie A. Kovacs, Roslyn M. Theisen
openaire   +3 more sources

Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

Frontiers in Physiology, 2017
NQO1 is one of the two major quinone reductases in mammalian systems. It is highly inducible and plays multiple roles in cellular adaptation to stress.
David Ross, David Siegel
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Cytochrome c and superoxide [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2013
ISSN:0949 ...
openaire   +4 more sources

Potential Modulation of Vascular Function by Nitric Oxide and Reactive Oxygen Species Released From Erythrocytes

Frontiers in Physiology, 2018
The primary role for erythrocytes is oxygen transport that requires the reversible binding of oxygen to hemoglobin. There are, however, secondary reactions whereby the erythrocyte can generate reactive oxygen species (ROS) and nitric oxide (NO). ROS such
Joseph M. Rifkind, Joseph M. Rifkind, Joy G. Mohanty, Enika Nagababu, Enika Nagababu, Maria T. Salgado, Zeling Cao   +6 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Magnetism of sodium superoxide [PDF]

CrystEngComm, 2014
10 pages, 7 ...
Z. V. Pchelkina, Z. V. Pchelkina, Vladimir V. Mazurenko, Igor Solovyev, Igor Solovyev   +4 more
openaire   +4 more sources

Role of nitric oxide and superoxide in Giardia lamblia killing

Brazilian Journal of Medical and Biological Research, 1997
Giardia lamblia trophozoites were incubated for 2 h with activated murine macrophages, nitric oxide (NO) donors or a superoxide anion generator (20 mU/ml xanthine oxidase plus 1 mM xanthine). Activated macrophages were cytotoxic to Giardia trophozoites (~
P.D. Fernandes, J. Assreuy
doaj   +1 more source