Results 31 to 40 of about 533,516 (306)
Mitochondrial Oxidative Metabolism: An Emerging Therapeutic Target to Improve CKD Outcomes
Biomedicines, 2023 Chronic kidney disease (CKD) predisposes one toward end-stage renal disease (ESRD) and its associated morbidity and mortality. Significant metabolic perturbations in conjunction with alterations in redox status during CKD may induce increased production ...
Kranti A. Mapuskar +5 more
doaj +1 more source
Frontiers in Genetics, 2016 It has become clear that mitochondrial reactive oxygen species (mtROS) are not simply villains and mitochondria the hapless targets of their attacks. Rather, it appears that mitochondrial dysfunction itself and the signaling function of mtROS can have ...
Siegfried Hekimi, Ying Wang, Alycia Noe
doaj +1 more source
What Is the Relevance of Murburn Concept in Thalassemia and Respiratory Diseases?
Thalassemia Reports, 2023 Murburn concept is a novel perspective for understanding cellular function, deeming cells as simple chemical engines (SCE) that are powered by redox reactions initiated by effective charge separation (ECS).
Kelath Murali Manoj
doaj +1 more source
S-adenosylmethionine and superoxide dismutase 1 synergistically counteract Alzheimer's disease features progression in tgCRND8 mice [PDF]
, 2017 Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism ...
Cavallaro, Rosaria A +4 more
core +2 more sources
Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity
Toxics, 2017 Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute ...
Clare Pace, Ruben Dagda, Jeff Angermann
doaj +1 more source
Novel NADPH Oxidase-2 Inhibitors as Potential Anti-Inflammatory and Neuroprotective Agents
Antioxidants, 2023 A family of seven NADPH oxidase enzymes (Nox1-5, Duox1-2) has been implicated in a variety of diseases, including inflammatory lung diseases, neurodegenerative diseases, cardiovascular diseases, and cancer.
Matea Juric +4 more
doaj +1 more source
Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase [PDF]
, 2012 Copper-zinc superoxide dismutase (SOD) is of fundamental importance to our understanding of oxidative damage. Its primary function is catalysing the dismutation of superoxide to O2 and H2O2. SOD also reacts with H2O2, leading to the formation of a strong
Luis Eduardo Soares Netto +4 more
core +3 more sources
Molecules, 2013 Novel antioxidants have been synthesized and characterized by their chemical properties as antioxidants with high superoxide scavenging activity. (2R,3R)-diphenylethylenediamine is a spacer in antioxidants, and we synthesized targets 11a and 11b by ...
Shigeki Kobayashi, Sachi Kanai
doaj +1 more source
Antioxidants, 2023 Black cumin seeds and seed oil have long been used in traditional foods and medicine in South Asian, Middle Eastern and Mediterranean countries and are valuable flavor ingredients. An important ingredient of black cumin is the small molecule thymoquinone
Raiyan Sakib +6 more
doaj +1 more source
Microsomal superoxide anion production and NADPH-oxidation in a series of 22 aziridinylbenzoquinones [PDF]
, 1989 Several 2,5-bis(1-aziridinyl)-1,4-benzoquinones (BABQs) can be activated to alkylating species by reduction of the quinone moiety. On the other hand, cytotoxicity of these compounds can be induced by redox cycling.
Koster, Andries Sj. +3 more
core +3 more sources