Results 101 to 110 of about 1,588,250 (283)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The Swedish Youth Labor Market in Boom and Depression [PDF]

open access: yes
This paper is concerned with the labor market experience of Swedish youths during the 1980s and the 1990s. The first objective is to portray early economic attainment among young Swedes. The second objective of the paper is to examine the impact of labor
Edin, Per-Anders   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Wage and employment effects of a wage norm : The Polish transition experience [PDF]

open access: yes
Most transition countries used tax-supported wage norms in the early 1990's, as a part of their market liberalization programs. This paper analyses how a firm-level tax (or subsidy) on deviations from a pre-set wage norm may promote employment by ...
Alain de Crombrugghe, Gregory de Walque
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Supported Employment

open access: yesSwiss Medical Forum ‒ Schweizerisches Medizin-Forum, 2011
U Hepp, B Dubs, U Bigler
  +4 more sources

Dagtilbud, en vei til deltakelse i ordinært arbeidsliv for personer med utviklingshemming?

open access: yesNordisk Välfärdsforskning
Arbeidsinkludering og arbeid for alle er sentrale politiske mål i Norge. Det er få personer med utviklingshemming som deltar i ordinært arbeidsliv. Personer med utviklingshemming har i hovedsak varig tilrettelagt arbeid (VTA) på skjermet arbeidsplass ...
Linda Barøy   +3 more
doaj   +1 more source

Disability employment policy [PDF]

open access: yes
This paper is the first in a series aimed at analyzing disability employment policy, and developing recommendations for policy reform in middle income countries.
Mont, Daniel
core  

Sector skills insights : construction [PDF]

open access: yes, 2012
The UK Commission for Employment and Skills is a social partnership, led by Commissioners from large and small employers, trade unions and the voluntary sector.
Atfield, Gaby   +6 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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