Results 101 to 110 of about 11,924,151 (347)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Swedish Youth Labor Market in Boom and Depression [PDF]
This paper is concerned with the labor market experience of Swedish youths during the 1980s and the 1990s. The first objective is to portray early economic attainment among young Swedes. The second objective of the paper is to examine the impact of labor
Edin, Per-Anders +2 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
BMC Urology, 2018 Background Reduced clinical exposure to urology at the undergraduate or internship level is the main explanation for the marked decrease in applicants to urology residencies.
Hwa Yeon Sun +4 more
doaj +1 more source
Wage and employment effects of a wage norm : The Polish transition experience [PDF]
Most transition countries used tax-supported wage norms in the early 1990's, as a part of their market liberalization programs. This paper analyses how a firm-level tax (or subsidy) on deviations from a pre-set wage norm may promote employment by ...
Alain de Crombrugghe, Gregory de Walque
core
Munkapiaci áramlások, gereblyézés és a 2008 végén kibontakozó gazdasági válság foglalkoztatási hatásai [PDF]
, 2010 Analyses of the Hungarian employment situation are almost always concerned only with the change in the number of the employed, unemployed and inactive, not paying particular attention to the flows between these states.
Cseres-Gergely, Zsombor
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Dagtilbud, en vei til deltakelse i ordinært arbeidsliv for personer med utviklingshemming?
Nordisk VälfärdsforskningArbeidsinkludering og arbeid for alle er sentrale politiske mål i Norge. Det er få personer med utviklingshemming som deltar i ordinært arbeidsliv. Personer med utviklingshemming har i hovedsak varig tilrettelagt arbeid (VTA) på skjermet arbeidsplass ...
Linda Barøy +3 more
doaj +1 more source
Public employment and the double role of bureaucrats [PDF]
Bureaucrats in the government sector have a double role since they are both suppliers and demanders of public employment; they are publicly employed (supply labor) and they have an important say in deciding the size of the municipal employment (demand ...
Dahlberg, Matz, Mörk, Eva
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source