Results 81 to 90 of about 8,443,769 (248)

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Bi-directional support of T lymphoma and a lymphoma-associated monocyte population involving Notch signaling in mice

OncoImmunology
Tumor-induced manipulations of myelomonocytic differentiation have been widely reported. Here, we describe the elicitation of a tumor-supportive cell type in a T lymphoma model in mice.
Sigrid Dubois, Yetzali Claudio-Medina, Jennifer L. Marte, James L. Gulley, Juergen R. Mueller   +4 more
doaj   +1 more source

Making sense of Wnt signaling – linking hair cell regeneration to development

Frontiers in Cellular Neuroscience, 2015
Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification.
Lina eJansson, Grace eKim, Alan G Cheng
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Hyperosmotic sisomicin infusion: a mouse model for hearing loss

Scientific Reports
Losing either type of cochlear sensory hair cells leads to hearing impairment. Inner hair cells act as primary mechanoelectrical transducers, while outer hair cells enhance sound-induced vibrations within the organ of Corti.
Ayse Maraslioglu-Sperber, Fabian Blanc, Stefan Heller, Nesrine Benkafadar   +3 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Planar cell polarity protein Celsr1 regulates endothelial adherens junctionsand directed cell rearrangements during lymphatic valve morphogenesis.

, 2013
Planar cell polarity (PCP) signaling controls tissue morphogenesis by coordinating collective cell behaviours. Here we show a critical role for the core PCP proteins Celsr1 and Vangl2 in the complex morphogenetic process of intraluminal valve formation ...
Devenport, Danelle, Weston, Anne, Taddei, Andrea, Makinen, Taija, Mäkinen, Taija,, Davenport, Danelle, Fuchs, Elaine, Tatin, Florence, Tissir, Fadel   +8 more
core   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Supporting data for Fig 2C—Frequency of meningeal cells derived from single-cell transcriptomics analysis.

, 2023
Supporting data for Fig 2C—Frequency of meningeal cells derived from single-cell transcriptomics analysis.
Lalit Kumar Dubey (5758280), Juan F. Quintana (8044493), Nono-Raymond Kuispond Swar (17420082), Gail McConnell (2180448), Michael Haley (7646750), Neil A. Mabbott (7361273), Luis de Lecea (711657), Annette MacLeod (12779), Matthew C. Sinton (11056182), Praveena Chandrasegaran (17420073), David Bending (17420085), Moumen Al Samman (17420079), John Ogunsola (17420076), Dieudonné Mumba Ngoyi (7889651)   +13 more
core   +1 more source

Data supporting Arf6 regulation of Schwann cell differentiation and myelination

Data in Brief, 2015
The data is related to the research article entitled “Arf6 mediates Schwann cell differentiation and myelination” [1]. To further investigate the role of Arf6 in promoting myelination by Schwann cells in vivo, we have characterized an another line (#2 ...
Tomohiro Torii, Yuki Miyamoto, Masahiro Yamamoto, Katsuya Ohbuchi, Hideki Tsumura, Kazuko Kawahara, Akito Tanoue, Hiroyuki Sakagami, Junji Yamauchi   +8 more
doaj   +1 more source