Results 61 to 70 of about 8,443,769 (248)

Stem Cell States, Fates, and the Rules of Attraction

, 2009
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different ...
Andrews, Peter W., Peterson, Carsten, Enver, Tariq, Pera, Martin, Peterson, Carsten,   +4 more
core   +1 more source

Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD

, 2023
Cell replacement therapies for Parkinson’s disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials.
Nina Rogelius, Mudannayake, Janitha,, Thea P. Lillethorup, Parmar, Malin,, Adler, Andrew F., Nelander, Jenny,, Janitha Mudannayake, Sørensen, Jens C.,, Lindvall, Olle, Tiago Cardoso, Deirdre B. Hoban, Jens C. Sørensen, Cutting, Emma,, Hjálmar Bjartmarz, van Vliet, Trinette, Lowdell, Mark, Nelander, Jenny, Jenny Nelander, Lindvall, Olle,, Parmar, Malin, Novo Nordisk Cell Therapy R&D,, Yu Zhang, Glud, Andreas N.,, Petter Storm, Landau, Anne M., Hoban, Deirdre B., Zhang, Yu,, Olle Lindvall, Lillethorup, Thea P., Cutting, Emma, Glud, Andreas N., Harry, Bronwen,, Storm, Petter,, Andrew F. Adler, Bain, Owen,, Fiorenzano, Alessandro,, Alessandro Fiorenzano, Sørensen, Jens C., van Vliet, Trinette,, Lund University., Bronwen Harry, Storm, Petter, Paul, Gesine,, Carla Carvalho, Widner, Håkan, Zhang, Yu, Mark Lowdell, Kirkeby, Agnete, Anne M. Landau, Bain, Owen, Bjartmarz, Hjálmar,, Carvalho, Carla, Emma Cutting, Widner, Håkan,, Håkan Widner, Shelby Vale, Fiorenzano, Alessandro, Lowdell, Mark,, Andreas N. Glud, Novo Nordisk Cell Therapy R&D, Malin Parmar, Anders Björklund, Mattsson, Bengt, Roger A. Barker, Mudannayake, Janitha, Paul, Gesine, Owen Bain, Rogelius, Nina,, Hoban, Deirdre B.,, Cardoso, Tiago,, Carvalho, Carla,, Gesine Paul, Agnete Kirkeby, Harry, Bronwen, Vale, Shelby,, Trinette van Vliet, Mattsson, Bengt,, Bengt Mattsson, Barker, Roger A., Björklund, Anders,, Rogelius, Nina, Bjartmarz, Hjálmar, Vale, Shelby, Cardoso, Tiago, Björklund, Anders, Kirkeby, Agnete,, Christiansen, Josefine Rågård, Lillethorup, Thea P.,, Landau, Anne M.,, Adler, Andrew F.,, Barker, Roger A.,   +90 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Sensors of Succinate : Neural Stem Cell Grafts Fight Neuroinflammation

, 2018
In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory ...
Olle Lindvall, Kokaia, Zaal, Zaal Kokaia, Lindvall, Olle, Kokaia, Zaal,, Lindvall, Olle,, Lund University.   +6 more
core   +1 more source

PI3K-C2 alpha Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation [PDF]

, 2018
Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin. A remaining question is to mechanistically explain how an insulin target cell/tissue can be insulin resistant ...
Berggren, PO, Leibiger, IB, Paschen, M, Yunn, NO, Lim, JH, Leibiger, B, Ryu, SH, Moede, T, Pereira, T   +8 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Top 30 enriched genes per supporting cell subcluster in P0 control cochlear duct.

, 2023
Top 30 enriched genes per supporting cell subcluster in P0 control cochlear duct.
Michael Ebeid (4234033), Pooja Roy (6716147), Mohd Ali Abbas Zaidi (16892383), Sung-Ho Huh (191072), Alan G. Cheng (11195475), Ippei Kishimoto (16892380)   +5 more
core   +1 more source

Unilateral zebrafish corneal injury induces bilateral cell plasticity supporting wound closure

Scientific Reports, 2022
The cornea, transparent and outermost structure of camera-type eyes, is prone to environmental challenges, but has remarkable wound healing capabilities which enables to preserve vision.
Kaisa Ikkala, Vassilis Stratoulias, Frederic Michon   +2 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Mind, mood and new neurons : Probing adult hippocampal neurogenesis in neuropsychiatry and beyond

In this issue of Cell Stem Cell, Márquez-Valadez, Gallardo-Caballero, and Llorens-Martín1 report that adult hippocampal neurogenesis (AHN) is differentially disrupted in neuropsychiatric disorders.
Tosoni, Giorgia, Salta, Evgenia, Salta, Evgenia,, Tosoni, Giorgia,, Lund University.   +4 more
core   +1 more source