Results 71 to 80 of about 5,601,937 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Barkhausen Noise Emission in Milled Surfaces

Communications, 2015
This paper deals with the non-destructive evaluation of surface made of roll bearing steel 100Cr6 after milling cycles via Barkhausen noise technique.
Miroslav Neslusan, Tomas Hrabovsky, Maria Cillikova, Anna Micietova   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Thermally Induced Surface Integrity Changes of Ground WC-Co Hardmetals [PDF]

, 2016
Ground hardmetals are exposed to high temperatures during both processing (e.g. coating deposition) and use (e.g. as a cutting tool). However, studies on thermally induced changes of surface integrity are limited.
Esteve, J., Yang, J., Roa, J.J., Roa, J. J.,, Llanes, L.,, Odén, M., Esteve, J.,, Schwind, M., Yang, Jie,, Schwind, M.,, Odén, Magnus,, Johansson-Jõesaar, M.P., Johansson-Jõesaar, Mats P.,, Llanes, L.   +13 more
core   +1 more source

Plasma-Assisted Regeneration of Activated Carbon: Current Status and Prospects

Inorganics
Activated carbon (AC) is widely used in pollution control, but it faces significant challenges in regeneration due to secondary pollution and structural degradation. Traditional methods, such as thermal and chemical regeneration, are energy-intensive and
Routong Chen, Jiaxin Meng, Shiyi Tan, Litao Liang, Faxing Wang, He Liu, Cong Guo, Weizhai Bao, Guozhen Zhang, Feng Yu   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Synergic Effects of Nanosecond Laser Ablation and PVD-Coating on Cemented Carbides: Assessment on Surface and Mechanical Integrity

, 2023
Emerging laser precision machining, particularly using pulsed lasers, enlightens the innovation and functionalization of cemented carbides. These backbone materials of the tooling industry are usually considered difficult to machine or shape using ...
Shiqi Fang, Y. B. Guo, Luis Llanes, Dirk Bähre   +3 more
core   +1 more source

Influence of the Drilling Parameters in the Single-Lip Deep-Hole Drilling Process on the Surface Integrity of Nickel-Based Alloy

Machines
Single-lip deep-hole drilling is a key technology for the precision machining of high-temperature nickel-based alloy pore structures in aero engines.
Tao Wu, Fangchao Zhang, Haoguang Zhou, Dong Zhang   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ultrasonic-Vibration-Superimposed Face Turning of Aluminium Matrix Composite Components for Enhancing Friction-Surface Preconditioning

Journal of Manufacturing and Materials Processing
Aluminium matrix composites (AMCs) represent an important group of high-performance materials. Due to their specific strength and a high thermal conductivity, these composites have been considered for the large-scale production of brake discs.
Patrick Eiselt, Sarah Johanna Hirsch, Ismail Ozdemir, Andreas Nestler, Thomas Grund, Andreas Schubert, Thomas Lampke   +6 more
doaj   +1 more source