Results 11 to 20 of about 1,012,835 (322)

Dissolution Improvement of Simvastatin by Surface Solid Dispersion Technology

Dissolution Technologies, 2010
The objective of the present study was to formulate surface solid dispersions (SSD) of simvastatin to improve the aqueous solubility and dissolution rate to facilitate faster onset of action. Simvastatin is a BCS Class II drug having low solubility (1.45 µg/mL) and therefore low oral bioavailability (5%).
Monica Rao, Yogesh Mandage, Kaushik Thanki, Sucheta Bhise   +3 more
openaire   +2 more sources

Formulation of solid dispersion and surface solid dispersion of nifedipine: A comparative study

African Journal of Pharmacy and Pharmacology, 2013
In this study, an attempt was taken to enhance the solubility and dissolution characteristics of nifedipine, a poorly water soluble calcium channel blocking agent, by preparing solid dispersions (SD) with water soluble carriers; Poloxamer 407, HPMC 5 cPs, polyethylene glycol (PEG) 4000 and 6000 and surface solid dispersions (SSD) with insoluble ...
A. Alam, Md. Abdullah Al Masum, Rezaur Bin Islam, F. Sharmin, M. S., Ashraful Islam   +5 more
openaire   +3 more sources

Enhancement of Dissolution of Telmisartan by Surface Solid Dispersion Technique

Journal of Pharmaceutical Research, 2012
Telmisartan is an Angiotensin Receptor Blocker (ARB) used for the treatment of hypertension. It belongs to BCS class-II i.e. low solubility and high permeability and exhibits variable bioavailability. The objective of the present study was to prepare surface solid dispersions of telmisartan to improve its aqueous solubility and dissolution rate.
Sood Neha, Khatry Sadhna, Arora Sandeep
openaire   +2 more sources

Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity

Drug Delivery, 2022
Triptolide (TP), a compound isolated from a Chinese medicinal herb, possesses potent anti-tumor, immunosuppressive, and anti-inflammatory properties, but was clinically limited due to its poor solubility, bioavailability, and toxicity.
Dabu Zhu, Qiuqin Zhang, Yifang Chen, Minghua Xie, Jianbo Li, Shen Yao, Ming Li, Zhao Lou, Yue Cai, Xuanrong Sun   +9 more
doaj   +2 more sources

Development, evaluation and characterization of surface solid dispersion for solubility and dispersion enhancement of irbesartan

Journal of Pharmacy Research, 2013
Abstract Aim The present study is to prepare and assess Irbesartan loaded surface solid dispersions (SSD) for enhancing the solubility and bioavailability of poor soluble drug. Method Irbesartan loaded SSD were prepared by co-evaporation method by using five different super disintegrants like crospovidone, croscarmellose sodium, potato starch ...
Bhagavanth Reddy Ganapuram, Madhusudhan Alle, Ramakrishna Dadigala, Girija Mangatayaru Kotu, Veerabhadram Guttena   +4 more
openaire   +2 more sources

Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

Pharmaceutics, 2021
Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of
Bhupendra Raj Giri, Jung Suk Kim, J. Park, S. Jin, Kyeong Soo Kim, F. Din, Han‐Gon Choi, Dong Wuk Kim   +7 more
semanticscholar   +1 more source

Wave Dispersion Behavior in Quasi-Solid State Concrete Hydration

Sensors, 2023
This paper aims to investigate wave dispersion behavior in the quasi-solid state of concrete to better understand microstructure hydration interactions. The quasi-solid state refers to the consistency of the mixture between the initial liquid–solid stage
Yin Chao Wu, Sanggoo Kang, Yeongseok Jeong, Dafnik Saril Kumar David, Suyun Ham   +4 more
doaj   +1 more source

CFD simulation of gas-liquid floating particles mixing in an agitated vessel [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2017
Gas dispersion and floating particles suspension in an agitated vessel were studied numerically by using computational fluid dynamics (CFD). The Eulerian multi-fluid model along with standard k-ε turbulence model was used in the simulation.
Li Liangchao, Xu Bin
doaj   +1 more source

FORMULATION DEVELOPMENT AND OPTIMISATION OF FAST DISSOLVING BUCCAL FILMS LOADED GLIMEPIRIDE SOLID DISPERSION WITH ENHANCED DISSOLUTION PROFILE USING CENTRAL COMPOSITE DESIGN

International Journal of Pharmacy and Pharmaceutical Sciences, 2023
Objective: This study aimed to enhance the solubility and dissolution of Glimepiride, a new-generation hypoglycaemic agent with low water solubility, by preparing Fast dissolving buccal films (FDBFs) containing Glimepiride solid dispersion.
P. Farooqui, R. Gude
semanticscholar   +1 more source

Surface Dispersion Suppression in High-Frequency GaN Devices

Crystals, 2022
GaN-based high electron mobility transistors (HEMTs) are shown to have excellent properties, showing themselves to perform well among the throng of solid-state power amplifiers.
Pengfei Zhu, Xianfeng Ni, Qian Fan, Xing Gu   +3 more
doaj   +1 more source