Results 61 to 70 of about 574,337 (298)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Development of Orodispersible Tablets with Solid Dispersions of Fenofibrate and Co-Processed Mesoporous Silica for Improved Dissolution

Pharmaceutics
Poor water solubility is an important challenge in the development of oral patient-friendly solid dosage forms. This study aimed to prepare orodispersible tablets with solid dispersions of a poorly water-soluble drug fenofibrate and a co-processed ...
Ana Baumgartner, Odon Planinšek
doaj   +1 more source

A mathematical model of metallized solid propellant combustion under the changing pressure

MATEC Web of Conferences, 2017
This paper presents the mathematical model describing a non-stationary combustion of metallized solid propellant. The model takes into account the heat transfer, the oxidizer decomposition and gasification of the solid propellant, two-phase, dual ...
Poryazov Vasily, Krainov Aleksei, Krainov Dmitry   +2 more
doaj   +1 more source

Investigation of the Interaction Mechanism of Solid Particles under Shock Waves

Shock and Vibration, 2022
To deeply understand the interaction mechanism between the two phases, both shock wave experiments and computational fluid dynamics (CFD) simulations are carried out to study the propagation of shock waves and the dispersion process of solid quartz sand ...
Xu Peng, Shunyao Wang, Guoning Rao, Bin Li, Wanghua Chen   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effect of Ion-Plasma Nitriding on Phase Composition and Tensile Properties of AISI 321-Type Stainless Steel Produced by Wire-Feed Electron-Beam Additive Manufacturing

Metals, 2022
We study the effect of ion-plasma surface nitriding on the phase composition, microstructure, surface microhardness, and tensile properties of the AISI 321-type stainless steel produced by wire-feed electron-beam additive manufacturing (EBAM). Ion-plasma
Valentina Moskvina, Elena Astafurova, Sergey Astafurov, Kseniya Reunova, Marina Panchenko, Eugenii Melnikov, Eugeny Kolubaev   +6 more
doaj   +1 more source

Development, evaluation and characterization of surface solid dispersion for solubility and dispersion enhancement of irbesartan

Journal of Pharmacy Research, 2013
Abstract Aim The present study is to prepare and assess Irbesartan loaded surface solid dispersions (SSD) for enhancing the solubility and bioavailability of poor soluble drug. Method Irbesartan loaded SSD were prepared by co-evaporation method by using five different super disintegrants like crospovidone, croscarmellose sodium, potato starch ...
Bhagavanth Reddy Ganapuram, Madhusudhan Alle, Ramakrishna Dadigala, Girija Mangatayaru Kotu, Veerabhadram Guttena   +4 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source