Results 61 to 70 of about 1,012,835 (322)

NMR as a Tool to Characterize the Aggregation Structure of Silica Nanoparticles in a Liquid

KONA Powder and Particle Journal, 2019
The NMR-based solvent relaxation technique, a non-invasive tool to characterize the surface of particles, which are dispersed in a liquid, was applied to characterize the nanoparticles’ aggregation structure.
Chika Takai-Yamashita, Emiko Sato, Masayoshi Fuji   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The theory of electron states on the dynamically deformed adsorbed surface of a solid

Condensed Matter Physics, 2018
Dispersion relations for the spectra of surface electron states on a dynamically deformed adsorbed surface of a monocrystal with the Zinc blende structure are received. It is established that the dependences of the band gap width and of the concentration
R.M. Peleshchak, M.Ya. Seneta
doaj   +1 more source

The dynamical distance and intrinsic structure of the globular cluster omega Centauri [PDF]

, 2005
We determine the dynamical distance D, inclination i, mass-to-light ratio M/L and the intrinsic orbital structure of the globular cluster omega Cen, by fitting axisymmetric dynamical models to the ground-based proper motions of van Leeuwen et al.
Bosch, R. C. E. van den, de Zeeuw, P. T., van de Ven, G., Verolme, E. K.   +3 more
core   +3 more sources

Mesoporous Silica as a Carrier for Amorphous Solid Dispersion [PDF]

, 2017
In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms.
S. P. Chaudhari, A. Gupte
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Investigation of the Interaction Mechanism of Solid Particles under Shock Waves

Shock and Vibration, 2022
To deeply understand the interaction mechanism between the two phases, both shock wave experiments and computational fluid dynamics (CFD) simulations are carried out to study the propagation of shock waves and the dispersion process of solid quartz sand ...
Xu Peng, Shunyao Wang, Guoning Rao, Bin Li, Wanghua Chen   +4 more
doaj   +1 more source

Exploiting the Hierarchical Morphology of Single-Walled and Multi-Walled Carbon Nanotube Films for Highly Hydrophobic Coatings [PDF]

, 2015
Self-assembled hierarchical solid surfaces are very interesting for wetting phenomena, as observed in a variety of natural and artificial surfaces. Here, we report single-walled (SWCNT) and multi-walled carbon nanotube (MWCNT) thin films realized by a ...
Cacciotti, Ilaria, Castrucci, Paola, De Crescenzi, Maurizio, De Nicola, Francesco, Nanni, Francesca, Scarselli, Manuela   +5 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source