Results 51 to 60 of about 807,388 (293)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Enhancing Cooperative Coevolution for Large Scale Optimization by Adaptively Constructing Surrogate Models

, 2018
It has been shown that cooperative coevolution (CC) can effectively deal with large scale optimization problems (LSOPs) through a divide-and-conquer strategy.
Chen, An, Liang, Yongsheng, Pang, Bei, Ren, Zhigang   +3 more
core   +1 more source

Efficient Benchmarking of Algorithm Configuration Procedures via Model-Based Surrogates [PDF]

, 2017
The optimization of algorithm (hyper-)parameters is crucial for achieving peak performance across a wide range of domains, ranging from deep neural networks to solvers for hard combinatorial problems.
Eggensperger, Katharina, Hoos, Holger H., Hutter, Frank, Leyton-Brown, Kevin, Lindauer, Marius   +4 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Titmice are a better indicator of bird density in Northern European than in Western European forests

Ecology and Evolution, 2022
Population sizes of many birds are declining alarmingly and methods for estimating fluctuations in species’ abundances at a large spatial scale are needed. The possibility to derive indicators from the tendency of specific species to co‐occur with others
Mira H. Kajanus, Jukka T. Forsman, Maximilian G. R. Vollstädt, Vincent Devictor, Merja Elo, Aleksi Lehikoinen, Mikko Mönkkönen, James T. Thorson, Sami M. Kivelä   +8 more
doaj   +1 more source

Use of a Novel DNA-Loaded Alginate-Calcium Carbonate Biopolymer Surrogate to Study the Engulfment of Legionella pneumophila by Acanthamoeba polyphaga in Water Systems

Microbiology Spectrum, 2022
The engulfment of Legionella pneumophila by free-living amoebae (FLA) in engineered water systems (EWS) enhances L. pneumophila persistence and provides a vehicle for rapid replication and increased public health risk.
Sujani Ariyadasa, Craig Billington, Mohamed Shaheen, Nicholas J. Ashbolt, Conan Fee, Liping Pang   +5 more
doaj   +1 more source

Inference in Complex Systems Using Multi-Phase MCMC Sampling With Gradient Matching Burn-in [PDF]

, 2017
We propose a novel method for parameter inference that builds on the current research in gradient matching surrogate likelihood spaces. Adopting a three phase technique, we demonstrate that it is possible to obtain parameter estimates of limited bias ...
Husmeier, Dirk, Lazarus, Alan, Papamarkou, Theodore   +2 more
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Determination of Bond Wire Failure Probabilities in Microelectronic Packages

, 2016
This work deals with the computation of industry-relevant bond wire failure probabilities in microelectronic packages. Under operating conditions, a package is subject to Joule heating that can lead to electrothermally induced failures.
Casper, Thorben, Römer, Ulrich, Schöps, Sebastian   +2 more
core   +1 more source