Results 91 to 100 of about 296,469 (371)

Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection [PDF]

open access: yes, 2015
published_or_final_versio
Abergel, A   +23 more
core   +1 more source

Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman   +4 more
wiley   +1 more source

Sofosbuvir/velpatasvir is an effective treatment for patients with hepatitis C and advanced fibrosis or cirrhosis in a real-world setting in Taiwan

open access: yesBMC Gastroenterology, 2021
Introduction Real-world data regarding the impact of hepatic fibrosis on the effectiveness of sofosbuvir/velpatasvir (SOF/VEL) treatment is limited in the Asian population. Methods We analyzed data for all 823 patients with hepatitis C virus treated with
Yu-Ting Huang   +11 more
doaj   +1 more source

A dynamic Bayesian nonlinear mixed-effects model of HIV response incorporating medication adherence, drug resistance and covariates

open access: yes, 2011
HIV dynamic studies have contributed significantly to the understanding of HIV pathogenesis and antiviral treatment strategies for AIDS patients. Establishing the relationship of virologic responses with clinical factors and covariates during long-term ...
Acosta, Edward P.   +3 more
core   +1 more source

Continual decision‐making dynamics across biological organisms

open access: yesBiological Reviews, EarlyView.
ABSTRACT Decision‐making is a central function of adaptive behaviour in biological agents. However, strategies for adaptive decision‐making can vary substantially across species. Here, we aim to extend the comparative scope of decision‐making analyses to phylogenetically diverse organisms.
Liberty Severs, Qiuran Wang
wiley   +1 more source

Injuries in deep time: interpreting competitive behaviours in extinct reptiles via palaeopathology

open access: yesBiological Reviews, EarlyView.
ABSTRACT For over a century, palaeopathology has been used as a tool for understanding evolution, disease in past communities and populations, and to interpret behaviour of extinct taxa. Physical traumas in particular have frequently been the justification for interpretations about aggressive and even competitive behaviours in extinct taxa.
Maximilian Scott   +3 more
wiley   +1 more source

Interferon-Free Regimen: Equally Effective in Treatment Naive and Experienced HCV Patients

open access: yesAnnals of Hepatology, 2019
Introduction and aim. Interferon-free regimen has been reported to be highly efficient in treatment of HCV infection, including patients with compensated cirrhosis. We compared the efficacy of Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir and Ribavirin (
Crina Fofiu   +6 more
doaj   +1 more source

Personalizing HIV therapy, mission impossible? [PDF]

open access: yes, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source

Liver-related morbidity and mortality in patients with chronic hepatitis C and cirrhosis with and without sustained virologic response

open access: yesClinical Epidemiology, 2017
Background Chronic hepatitis C (CHC) causes liver cirrhosis in 5%–20% of patients, leading to increased morbidity and mortality. This study aimed to estimate liver-related morbidity and mortality among patients with CHC and cirrhosis in Denmark with and ...
S. Hallager   +12 more
semanticscholar   +1 more source

Long‐term trends in parasite diversity and infection levels: approaches and patterns

open access: yesBiological Reviews, EarlyView.
ABSTRACT Parasites exist in every ecosystem, affecting nearly all organisms and playing a complex role in human societies. On the one hand, they contribute substantially to biodiversity and support ecosystem stability by performing essential ecological functions.
Cyril Hammoud   +8 more
wiley   +1 more source

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