Results 121 to 130 of about 296,469 (371)

Achieving sustained virologic response after interferon‐free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis

Journal of Viral Hepatitis, 2016
Chronic hepatitis C virus (HCV) infection can now be treated with oral directly acting antiviral agents, either with or without ribavirin (RBV). Virologic relapse after treatment can occur, and in some studies was more common in cirrhotic subjects.
Eric G. Meissner, Eric G. Meissner, Anita Kohli, Anita Kohli, K. Virtaneva, D. Sturdevant, Craig Martens, S. Porcella, J. Mchutchison, H. Masur, Shyamasundaran Kottilil, Shyamasundaran Kottilil   +11 more
semanticscholar   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

Biotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya, Rajesh K. Mistry, Susie Sou, Sonja Hess, Bijay Khanal, Zayla Schaeffer, Jie Zhu, Lina Chakrabarti   +7 more
wiley   +1 more source

Efficacy and Safety of In-Asia-manufactured Interferon Alpha-2b in Combination with Ribavirin for Therapy of Naïve Chronic Hepatitis C Patients: a Multicenter, Prospective, Open-Label Trial [PDF]

, 2009
Background: An open-label, multi center and non-comparative study was conducted to evaluate the efficacy and safety of a more affordable in-Asia-manufactured interferon á-2b product in combination with ribavirin to treat naïve chronic hepatitis C ...
Akbar, N. (Nurul), Gani, R. A. (Rino), Hasan, I. (Irsan), Lesmana, L. (Laurentius), Noer, S. (Sjaifoellah), Pridady, F. (FX), Sanityoso, A. (Andri), Soemarno, S. (Soemarno), Sulaiman, A. (Ali)   +8 more
core   +1 more source

Non-Hodgkin's Lymphoma as an Extrahepatic Manifestation after Achieving Sustained Virologic Response for Hepatitis C Viral Infection [PDF]

, 2023
Mihaela Ghioca, Speranţa Iacob, Ioana Gabriela Lupescu, Gabriel Becheanu, Daniel Coriu, Camelia Dobrea, Adrian Costache, Alexandru G. Bardas, Cristian Gheorghe, Liliana Gheorghe   +9 more
openalex   +1 more source

Dynamics of natural killer cell function upon recurrent stimulation

Biotechnology Progress, EarlyView.
Weekly stimulation of peripheral blood‐derived NK cells with engineered K562 feeder cells resulted in two distinct growth phases, shifting around Day 21–26. Cells in growth phase 2 exhibited slower growth, reduced metabolic activity, and lower cytotoxicity than cells from growth phase 1, which has implications for NK cell biomanufacturing.
Jennifer One, Janani Narayan, Frank Cichocki, Wei‐Shou Hu, Samira M. Azarin   +4 more
wiley   +1 more source

Safety and efficacy of direct-acting antivirals for chronic hepatitis C in patients with chronic kidney disease

BMC Nephrology, 2020
Background This is a real-world evidence study that aims to analyze the efficacy, tolerability and safety profile of paritaprevir/ombitasvir/ritonavir and dasabuvir, in patients with renal impairment.
Elena Laura Iliescu, Adriana Mercan-Stanciu, Letitia Toma   +2 more
doaj   +1 more source

A randomized controlled trial of pretransplant antiviral therapy to prevent recurrence of hepatitis C after liver transplantation [PDF]

, 2013
Hepatitis C virus (HCV) infection recurs in liver recipients who are viremic at transplantation. We conducted a randomized, controlled trial to test the efficacy and safety of pretransplant pegylated interferon alpha‐2b plus ribavirin (Peg‐IFN‐α2b/RBV ...
Al‐Osaimi, Abdullah MS, Brown, Robert S, Del R. Rodrigo, Everhart, James E, Everson, Gregory T, Gillespie, Brenda W, Kulik, Laura M, Lok, Anna S, Saab, Sammy, Shiffman, Mitchell L, Study, and the Adult‐to‐Adult Living Donor Liver Transplantation Cohort, Terrault, Norah A   +11 more
core   +1 more source

Development of a co‐culture of Ureibacillus thermosphaericus and Cupriavidus taiwanensis for inhibitors removal from hemicellulose prehydrolysate

Biotechnology Progress, EarlyView.
For biofuels production, hemicellulose pre‐hydrolysate is considered as an attractive feedstock rich in fermentable sugars. The pre‐hydrolysate derived from lignocellulosic biomass comprises, along with sugars, several inhibitors which can hamper its efficient conversion.
Mariem Theiri, Mariya Marinova, Hassan Chadjaa, Mario Jolicoeur   +3 more
wiley   +1 more source

Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis

Brazilian Journal of Infectious Diseases
BACKGROUND AND OBJECTIVES: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis.
Nelson Cheinquer, Hugo Cheinquer, Fernando H Wolff, Silvia Coelho-Borges   +3 more
doaj   +1 more source

New virologic tools for management of chronic hepatitis B and C.: New Virological Tools [PDF]

, 2012
International audienceMolecular biology techniques are routinely used to diagnose and monitor treatment of patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These tools can detect and quantify viral genomes and analyze
Chevaliez, Stéphane, Pawlotsky, Jean-Michel, Rodriguez, Christophe   +2 more
core   +3 more sources