Advances of capillary electrophoresis enantioseparations in pharmaceutical analysis (2017–2020)
ELECTROPHORESIS, Volume 42, Issue 17-18, Page 1709-1725, September 2021., 2021 Abstract Capillary electrophoresis is a powerful technique for the analysis of polar chiral compounds and has been widely accepted for analytical enantioseparations of drug compounds in pharmaceuticals and biological media. In addition, many mechanistic studies have been conducted in an attempt to rationalize enantioseparations in combination with ...
Sulaiman Krait +2 more
wiley +1 more source
The pipeline of new molecules and regimens against drug-resistant tuberculosis
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2021 The clinical development and regulatory approval of bedaquiline, delamanid and pretomanid over the last decade brought about significant progress in the management of drug-resistant tuberculosis, providing all-oral regimens with favorable safety profiles.
Todd A. Black, Ulrike K. Buchwald
doaj +1 more source
A Tandem Ring Closure and Nitrobenzene Reduction with Sulfide Provides an Improved Route to an Important Intermediate for the Anti-Tuberculosis Drug Candidate Sutezolid. [PDF]
Org Process Res DevSutezolid is an in-development thiomorpholine derivative of the FDA-approved tuberculosis (TB) treatment linezolid. Current synthetic routes for preparing sutezolid start with thiomorpholine as a key structural building block; unfortunately, this material was identified as a major cost driver for the API, which will limit the potential uptake of this ...
Kalmode HP +7 more
europepmc +3 more sources
Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects
Molecules, 2021 This review covers the main aspects concerning the chemistry, the biological activity and the analytical determination of oxazolidinones, the only new class of synthetic antibiotics advanced in clinical use over the past 50 years.
Claudia Foti +3 more
doaj +1 more source
Pharmacokinetics of tedizolid, sutezolid, and sutezolid-M1 in non-human primates
European Journal of Pharmaceutical Sciences, 2020 Non-human primates (NHP) are thought to be a good preclinical animal model for tuberculosis because they develop disease characteristics that are similar to humans. The objective of the current study was to determine if NHPs can also be used to reliably predict the exposure of tedizolid, sutezolid, and its biologically active metabolite sutezolid-M1 in
Sarah Kim +12 more
openaire +2 more sources
Culture-Free Enumeration of Mycobacterium tuberculosis in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development [PDF]
, 2022 BACKGROUND: The turnaround times for phenotypic tests used to monitor the bacterial load of Mycobacterium tuberculosis, in both clinical and preclinical studies, are delayed by the organism’s slow growth in culture media.
Clark, S +7 more
core +2 more sources
Tuberculosis: Development of New Drugs and Treatment Regimens
Jurnal Respirasi, 2021 Tuberculosis (TB) still becomes a public health crisis. Drug-resistant TB (DR-TB) becomes a concern as the increasing DR-TB cases in countries with high TB burden.
Soedarsono Soedarsono
doaj +1 more source
Issues in design and interpretation of MDR-TB clinical trials: report of the first Global MDR-TB Clinical Trials Landscape Meeting [PDF]
, 2015 Recognizing that the current MDR-TB regimen is suboptimal and based on low-quality evidence, the Global MDR-TB Clinical Trials Landscape Meeting was held in December, 2014 to strategize about coordination of research and development of new treatment ...
Bain, Lisa J +3 more
core +5 more sources
Biomedicines, 2022 Tuberculosis (TB) is accountable for considerable global morbidity and mortality. Effective TB therapy with multiple drugs completes in about six months.
Mohd. Imran +14 more
doaj +1 more source
Linezolid pharmacokinetics in MDR-TB : a systematic review, meta-analysis and Monte Carlo simulation [PDF]
, 2018 This work was supported by the Wellcome Trust (grant numbers 109129/Z/15/Z to JM and 105620/Z/14/Z to DS and MC).Objectives The oxazolidinone linezolid is an effective component of drug - resistant TB treatment, but use is limited by toxicity and the ...
Alffenaar, Jan-Willem C +11 more
core +5 more sources