Conservation of residues in an alignment of 758 sequences from a BLAST search of SV2A.
, 2015 Conservation of residues in an alignment of 758 sequences from a BLAST search of SV2A.
Jiye Shi (631279) +5 more
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Longitudinal [18F]SynVesT-1 PET targeting SV2A in PPMI (PPMI SV2A PET Imaging) v1
This protocol details the longitudinal [18F]SynVesT-1 PET targeting SV2A in PPMI (PPMI SV2A PET Imaging).
openaire +1 more source
SV2A-EGFP is trafficked to presynaptic terminals.
, 2013 Neurons expressing either EGFP or an SV2A-EGFP fusion protein were fixed and processed for immunolabeling. In neurons expressing EGFP green fluorescence was present throughout the length of neurites, whereas in neurons expressing SV2A-EGFP green ...
Amy Nowack (336337) +5 more
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The absence of SV2A protein in the hippocampus does not lower the epileptic threshold.
, 2016 A: Western blot analyses revealing SV2A protein depletion in the hippocampus of Grik4:SV2A-cKO mice in comparison with that of WTs. A’: Quantification of the SV2A proteins extracted from the hippocampus of WT and Grik4:SV2A-cKO mice (n = 3/group, data ...
Guillaume Becker (1811236) +9 more
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Conditional removal of the SV2A exon 3 in Ubiquitin-positive cells led to seizure.
, 2016 A: Illustration of the homologous recombination strategy used to generate the SV2A lox/lox allele. The SV2A gene is located on chromosome 3, composed of 13 exons.
Guillaume Becker (1811236) +9 more
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Levetiracetam influences downstream protein interactions at synapses expressing SV2A [PDF]
, 2019 Although levetiracetam is one of the most widely prescribed antiepileptic drugs, its mechanism of action remains unknown beyond the binding to the synaptic vesicle protein SV2A. SV2A is one of the three paralogs of the SV2 family.
MARCOTULLI, DANIELE
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SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment
, 2005 Synaptic vesicle protein 2 (SV2) is expressed in neuroendocrine cells as three homologous isoforms, SV2A, SV2B and SV2C. Ca2+-dependent function in exocytosis has been attributed to SV2A and SV2B, without elucidation of the mechanism.
Theander, Sten +4 more
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Evaluation of [11C]UCB-A positron emission tomography in human brains
EJNMMI ResearchBackground In preclinical studies, the positron emission tomography (PET) imaging with [11C]UCB-A provided promising results for imaging synaptic vesicle protein 2A (SV2A) as a proxy for synaptic density.
Mengfei Xiong +6 more
doaj +1 more source
Study of the SV2A protein role in Epilepsy
Frontiers in Aging Neuroscience, 2016 Bartholomé Odile +9 more
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Synaptic vesicle protein 2A (SV2A) and connexin 43 (Cx43) as targets for epilepsy: establishment of assays and identification of ligands [PDF]
, 2017 Epilepsy is a chronic neurological disorder affecting around 1% of the human population worldwide. The antiepileptic drugs (AEDs) available on the market provide symptomatic relief from epilepsy but do not cure the disease.
Danish, Azeem
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