Results 91 to 100 of about 4,076 (204)

SV2 mediates entry of tetanus neurotoxin into central neurons. [PDF]

PLoS Pathogens, 2010
Tetanus neurotoxin causes the disease tetanus, which is characterized by rigid paralysis. The toxin acts by inhibiting the release of neurotransmitters from inhibitory neurons in the spinal cord that innervate motor neurons and is unique among the ...
Felix L Yeh, Min Dong, Jun Yao, William H Tepp, Guangyun Lin, Eric A Johnson, Edwin R Chapman   +6 more
doaj   +1 more source

Decomposing SV2A Function and Dysfunction one Neuron at a Time

Epilepsy Currents
Synaptic Vesicle Glycoprotein 2A Knockout in Parvalbumin and Somatostatin Interneurons Drives Seizures in the Postnatal Mouse Brain Bartholome O, Neirinckx V, De La Brassinne O, Desloovere J, Van Den Ackerveken P ...
Mona Safari, Matthew C. Weston
openaire   +2 more sources

Evaluating the In Vivo Specificity of [¹⁸F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET

Molecules, 2019
The synaptic vesicle protein 2 (SV2) is involved in synaptic vesicle trafficking. The SV2A isoform is the most studied and its implication in epilepsy therapy led to the development of the first SV2A PET radiotracer [18F]UCB-H.
Maria Elisa Serrano, Guillaume Becker, Mohamed Ali Bahri, Alain Seret, Nathalie Mestdagh, Joël Mercier, Frédéric Mievis, Fabrice Giacomelli, Christian Lemaire, Eric Salmon, André Luxen, Alain Plenevaux   +11 more
doaj   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, Volume 11, Issue 5, Page 1395-1412, October 2026.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling [PDF]

Following exocytosis, the recapture of plasma membrane-stranded vesicular proteins into recycling synaptic vesicles (SVs) is essential for sustaining neurotransmission. Surface clustering of vesicular proteins has been proposed to act as a ‘pre-assembly’
Jiang, Anmin, Kontaxi, Christiana, Small, Christopher, Martínez‐mármol, Ramón, Malapaka, Anusha, Gormal, Rachel S., Pronot, Marie, Joensuu, Merja, Harper, Callista, Davenport, Elizabeth C.; id_orcid, Cousin, Michael A.; id_orcid, Yak, Nyakuoy, Meunier, Frédéric A., Wallis, Tristan P.   +13 more
core   +1 more source

Assessment of changes in synaptic density in the zQ175DN mouse model of Huntington’s disease: a [18F]SynVesT-1 study

NeuroImage: Clinical
Huntington’s disease (HD) is a neurodegenerative disorder characterized by involuntary movements, cognitive decline and psychiatric problems. HD has been associated with synaptic dysfunction and loss of the synaptic vesicle protein 2A (SV2A).
Liesbeth Everix, Franziska Zajicek, Annemie Van Eetveldt, Longbin Liu, Jonathan Bard, Steven Staelens, Daniele Bertoglio   +6 more
doaj   +1 more source

Salience network hub dysfunction is associated with cognitive impairment in self‐limited epilepsy with centrotemporal spikes: An OPM‐MEG study

Epilepsia Open, Volume 11, Issue 5, Page 1706-1717, October 2026.
Abstract Objective Self‐limited epilepsy with centrotemporal spikes (SeLECTS), although characterized by well‐controlled seizures, is frequently associated with persistent cognitive deficits in affected children. This study aimed to investigate whether hub dysfunction of the salience network (SN) is associated with cognitive impairment in SeLECTS ...
Chen Yang, Guangsheng Wu, Nan An, Tiejia Jiang, Yilong Wang, Wenbin Zhao, Wangyang Cao, Xiaofang Wang, Haiteng Jiang, Zhefeng Yuan   +9 more
wiley   +1 more source

Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A)

Brivaracetam (BRV) and levetiracetam (LEV) are antiseizure medications (ASMs); UCB-J is a PET tracer targeting synaptic vesicle protein 2A (SV2A); UCB7361 is closely related to padsevonil, an experimental anticonvulsant; while UCB1244283 acts as an ...
Wolff, Christian, Martin, Matthew F., Hall, Adrian, Ledecq, Marie, Gillard, Michel, Provins, Laurent, Horanyi, Peter S., Coleman, Jonathan A., Mittal, Anshumali   +8 more
core   +1 more source

DECREASE study: A European pool‐analysis of patients with significant reductions in concomitant antiseizure medications in cenobamate Early Access Programs

Epilepsia Open, Volume 11, Issue 5, Page 1812-1824, October 2026.
Abstract Objective To evaluate the effectiveness and tolerability of cenobamate in patients with a significant reduction in concomitant antiseizure medication (ASM) in European cenobamate Early Access Programs (EAPs). Method Anonymized patient data from real‐world studies/registries associated with European cenobamate EAPs were pooled.
Vicente Villanueva, Simona Lattanzi, Javier Peña‐Ceballos, Rhys H. Thomas, Juan Rodríguez‐Uranga, Zsófia Jordán, Bernhard J. Steinhoff, Randi von Wrede, Norman Delanty, Patrick B. Moloney, Roberta Roberti, Giovanni Boero, Laura Canafoglia, Nicola Specchio, Antonio Gambardella, Edoardo Ferlazzo, Francesca Felicia Operto, Elena Tartara, Hester Garratt, Dániel Fabó, Asier Gómez‐Ibáñez, Gustavo Torres‐Gaona, Yulia Novitskaya, Rainer Surges, Kevin Hampel, Andreas Schulze‐Bonhage   +25 more
wiley   +1 more source

Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology

NeuroImage
Neurodegeneration, accumulation of β-amyloid (Aβ) plaques, and neuroinflammation are the major hallmarks of Alzheimer's disease. Here, we aimed to investigate the temporal and spatial association between synaptic activity, Aβ plaque load, and ...
L.H. Kunze, G. Palumbo, J. Gnörich, K. Wind-Mark, R. Schaefer, S. Lindner, F.-J. Gildehaus, S. Ziegler, M. Brendel   +8 more
doaj   +1 more source