Results 101 to 110 of about 4,076 (204)

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Lower synaptic density is associated with depression severity and network alterations

Nature Communications, 2019
Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is ...
Sophie E. Holmes, Dustin Scheinost, Sjoerd J. Finnema, Mika Naganawa, Margaret T. Davis, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo A. Angarita, Robert H. Pietrzak, Ronald S. Duman, Gerard Sanacora, John H. Krystal, Richard E. Carson, Irina Esterlis   +14 more
doaj   +1 more source

Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning

EJNMMI Physics
Purpose Synaptic vesicle glycoprotein 2 A (SV2A) in human brains is an important biomarker of synaptic loss associated with several neurological disorders.
Xinyuan Zheng, Patrick Worhunsky, Qiong Liu, Xueqi Guo, Xiongchao Chen, Heng Sun, Jiazhen Zhang, Takuya Toyonaga, Adam P. Mecca, Ryan S. O’Dell, Christopher H. van Dyck, Gustavo A. Angarita, Kelly Cosgrove, Deepak D’Souza, David Matuskey, Irina Esterlis, Richard E. Carson, Rajiv Radhakrishnan, Chi Liu   +18 more
doaj   +1 more source

SV2A is expressed in synapse subpopulations in mouse and human brain: implications for PET radiotracer studies [version 1; peer review: 2 approved]

Wellcome Open Research
Synapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients.
Adriana Tavares, Zhen Qiu, Beverley Notman, Colin Smith, Theresa Wong, Seth G. N. Grant   +5 more
doaj   +1 more source

Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.

, 2012
peer reviewedSynaptic vesicle protein 2 (SV2) is a glycoprotein that exists in three isoforms, SV2A, SV2B, and SV2C. SV2A knockout (KO) mice and SV2A/SV2B double KO (DKO) mice, but not SV2B KO animals, start to experience severe seizures and weight loss ...
Alice Marquet, Doupagne, Melissa, Kumar Venkatesan, Vincent Seutin, Marquet, Alice, Alix, Philippe, Venkatesan, Kumar, Bernard Rogister, Seutin, Vincent, Philippe Alix, Isabelle Niespodziany, Niespodziany, Isabelle, Melissa Doupagne, ROGISTER, Bernard   +13 more
core   +1 more source

Puzzling Out Synaptic Vesicle 2 Family Members Functions

Frontiers in Molecular Neuroscience, 2017
Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many
Odile Bartholome, Priscilla Van den Ackerveken, Judit Sánchez Gil, Orianne de la Brassinne Bonardeaux, Pierre Leprince, Rachelle Franzen, Bernard Rogister, Bernard Rogister   +7 more
doaj   +1 more source

Increased Expression of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Brain of Chronic Diabetic Rats

Aim/hypothesisDiabetes mellitus has been reported to be a risk factor for cognitive dysfunction, depression, stroke, and seizures. Diabetic pathology is believed to interfere with synaptic plasticity.
Pazarlar, Burcu Azak, Egilmez, Cansu Bilister, Oyar, Eser Öz, Mikkelsen, Jens D.   +3 more
core   +1 more source

Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons

Journal of Pain Research, 2011
Yiangos Yiangou1 Uma Anand1,2, William R. Otto2, Marco Sinisi3, Michael Fox3, Rolfe Birch3 Keith A. Foster4, Gaurav Mukerji1,5, Ayesha Akbar1,6, Sanjiv K.
Yiangou Y, An, U, Otto WR, Sinisi M, Fox M, Birch R, Foster KA, Mukerji G, Akbar A, Agarwal SK, An, P   +12 more
doaj  

SV2A Synapse Diversity Project

An analysis of the expression of SV2A in human and mouse brain synapsesSynapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients.
School of Regeneration and Repair, Edinburgh Neuroscience, Grant, Seth, Centre for Clinical Brain Sciences   +3 more
core  

Synaptic Vesicle Glycoprotein 2A (SV2A) as a Measure of Synaptic Plasticity in Animal Models of Depression [PDF]

, 2019
Depression associeres med synapsetab grundet en nedregulering af vigtige proteiner involveret i opretholdelsen af synapser. Et foreslået indirekte mål for synapsedensitet er det præsynaptiske protein SV2A.
Ali, Saba, Labrouzi, Mariam
core