Results 81 to 90 of about 4,076 (204)

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, Volume 38, Issue 60, 27 October 2026.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Plasma β‐synuclein associates with hippocampal synaptic density measured with [11C]UCB‐J PET and plasma tau markers in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Plasma β‐synuclein is a promising blood‐based synaptic biomarker, but relationships with synaptic density as indicated by [11C]UCB‐J positron emission tomography (PET), and blood biomarkers of Alzheimer's disease (AD) pathology, neurodegeneration, and astrocyte activation need further characterization.
Darby C Peter, Max McLachlan, Alexandra H DiFilippo, Kao Lee Yang, Mary‐Elizabeth Pasquesi, Todd E Barnhart, Jonathan W Engle, Tobey J Betthauser, Sanjay Asthana, Sterling C Johnson, Bradley T Christian, Barbara B Bendlin, Markus Otto, Patrick Oeckl   +13 more
wiley   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3534-3545, October 2026.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

Synaptic Vesicle Protein SV2B, but Not SV2A, Is Predominantly Expressed and Associated with Microvesicles in Rat Pinealocytes [PDF]

Journal of Neurochemistry, 1998
Abstract: Microvesicles are endocrine counterparts of neuronal synaptic vesicles, and accumulate and secrete classic neurotransmitters. In mammalian pinealocytes, microvesicles accumulate l‐glutamate through a vesicular glutamate transporter and secrete it through exocytosis.
M, Hayashi, S, Yatsushiro, H, Yamada, A, Yamamoto, M, Futai, A, Yamaguchi, Y, Moriyama   +6 more
openaire   +3 more sources

Synaptic expression of SV2A in mouse and human brain

Synapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients.
Tavares, Adriana, Cerebrovascular Research Group, School of Regeneration and Repair, Edinburgh Neuroscience, Grant, Seth, Qiu, Zhen, Notman, Beverly, Centre for Clinical Brain Sciences, Smith, Colin; id_orcid, Wong, Theresa   +9 more
core   +1 more source

Specific invalidation of SV2A in the CA3 and DG areas of the adult hippocampus.

, 2016
A: Cre-mediated EYFP reporter expression demonstrating Cre recombination in the CA3 and DG areas of the hippocampus of Grik4-CRE/SV2ALox/Lox/-ROSA-EYFP mice, versus controls (i.e.: SV2Alox/lox/ROSA-EYFP) (Green: e-YFP; blue: Hoechst; scale bar = 250μm ...
Guillaume Becker (1811236), Sabine Wislet (3353177), Catherine Menten-Dedoyart (268642), Priscilla Van den Ackerveken (3353168), Odile Bartholome (3353174), Virginie Neirinckx (129045), Judit Sánchez Gil (3353171), Alain Plenevaux (1638856), Maria Elisa Serrano Navacerrada (3353165), Bernard Rogister (4738)   +9 more
core   +1 more source

Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer’s disease: associations with Aβ, tau, synaptic proteins and APOE ε4

Translational Neurodegeneration
Background Alzheimer’s disease (AD) is characterized by accumulation of amyloid-β (Aβ) plaques, tau neurofibrillary Tangles and synaptic dysfunction.
Jana Nussbaumer, Aatmika Barve, Valentin Zufferey, Jeanne Espourteille, Tunahan Kirabali, Uwe Konietzko, Daniel Razansky, Axel Rominger, Agneta Nordberg, Luc Buée, Morvane Colin, Roger M. Nitsch, Christoph Hock, Kevin Richetin, Ruiqing Ni   +14 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, Volume 67, Issue 10, Page 5075-5125, October 2026.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse

Epilepsia, Volume 67, Issue 10, Page 5026-5041, October 2026.
Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper, Zining Liu, Aristea S. Galanopoulou, Gernot Hlauschek, Benjamin Sinclair, Wai Lam Leung, Stefanie Dedeurwaerdere, Elisabeth Doran, Solomon L. Moshé, David C. Henshall, Ozlem Akman, Pablo M. Casillas‐Espinosa   +11 more
wiley   +1 more source

Generation of a SV2A knockout human embryonic stem cell line by CRISPR/Cas9 system

Stem Cell Research
Synaptic Vesicle Glycoprotein 2A (SV2A) is a ubiquitously expressed brain glycoprotein, localized to synaptic terminals. It regulates vesicle exocytosis, maintains neurotransmitter release, and serves as a receptor for both botulinum neurotoxins (e.g ...
Feng Yao, Xing Qi, Shan Yongli, Zhong Xiaofen   +3 more
doaj   +1 more source