Results 1 to 10 of about 102,695 (50)

Bioinspired mechano-photonic artificial synapse based on graphene/MoS2 heterostructure

Science Advances, 2021
A bioinspired mechano-photonic artificial synapse with synergistic mechanical and optical plasticity is demonstrated. Developing multifunctional and diversified artificial neural systems to integrate multimodal plasticity, memory, and supervised learning
Jinran Yu, Xixi Yang, Guoyun Gao, Yao Xiong, Yifei Wang, Jing Han, Youhui Chen, Huai Zhang, Qijun Sun, Zhong Lin Wang   +9 more
semanticscholar   +1 more source

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Nature Aging, 2022
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, V. Gandham, Christopher M. Rose, C. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, R. Edmonds, A. De Mazière, Raphael Rakosi-Schmidt, T. Singh, J. Klumperman, O. Foreman, Michael C Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson   +21 more
semanticscholar   +1 more source

Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Nature Communications, 2021
The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia/macrophages and astrocytes are differentially involved in engulfing synapses
Xiaojing Shi, Long-long Luo, Jixian Wang, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon-Hyuk Lee, Hengli Tian, Zhi-jun Zhang, Yongting Wang, Won-Suk Chung, Yaohui Tang, Guo-Yuan Yang   +14 more
semanticscholar   +1 more source

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.

Journal of Clinical Investigation, 2020
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we have demonstrated a potent IFN immunogenicity of nucleic acid (NA)-containing amyloid fibrils in the periphery.
Ethan R. Roy, Baiping Wang, Ying-Wooi Wan, G. Chiu, Allysa L Cole, Zhuoran Yin, Nicholas E. Propson, Yin Xu, J. Jankowsky, Zhandong Liu, V. Lee, J. Trojanowski, S. Ginsberg, O. Butovsky, Hui Zheng, Wei Cao   +15 more
semanticscholar   +1 more source

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Alzheimer's Research & Therapy, 2020
Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approaches for AD therapeutics ...
M. Colom‐Cadena, Tara L. Spires‐Jones, Henrik Zetterberg, K. Blennow, Anthony O. Caggiano, Steven T. DeKosky, Howard M. Fillit, John E. Harrison, Lon S. Schneider, P. Scheltens, W. de Haan, M. Grundman, C. V. van Dyck, Nicholas J. Izzo, Susan M. Catalano   +14 more
semanticscholar   +1 more source

Vertical organic synapse expandable to 3D crossbar array

Nature Communications, 2020
Recently, three-terminal synaptic devices have attracted considerable attention owing to their nondestructive weight-update behavior, which is attributed to the completely separated terminals for reading and writing.
Yongsuk Choi, Seyong Oh, C. Qian, Jin-Hong Park, J. Cho   +4 more
semanticscholar   +1 more source

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

bioRxiv, 2019
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes.
Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma, S. Ha, Nicholas J. Luciano, Cory M Willis, G. Gao, S. Crocker, B. Popko, D. Reich, D. Schafer   +10 more
semanticscholar   +1 more source

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Nature Neuroscience, 2019
Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic connectivity. The extracellular signals, particularly neuron-derived molecules, that drive these microglial functions at synapses remain a key open question ...
Georgia Gunner, Lucas Cheadle, Kasey M. Johnson, Pinar Ayata, Ana Badimon, Erica Mondo, Aurel Nagy, Liwang Liu, S. Bemiller, Ki-Wook Kim, S. Lira, B. Lamb, A. Tapper, R. Ransohoff, M. Greenberg, A. Schaefer, D. Schafer   +16 more
semanticscholar   +1 more source

An Oxide Schottky Junction Artificial Optoelectronic Synapse.

ACS Nano, 2019
The rapid development of artificial intelligence techniques and future advanced robot systems sparks emergent demand on the accurate perception and understanding of the external environments via visual sensing systems that can co-locate the self-adaptive
Shuang Gao, Gang Liu, Huali Yang, Chao Hu, Qilai Chen, Guodong Gong, Wuhong Xue, Xiaohui Yi, J. Shang, Run‐Wei Li   +9 more
semanticscholar   +1 more source

Neuron-Glia Signaling in Synapse Elimination.

Annual Review of Neuroscience, 2019
Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role.
D. Wilton, Lasse Dissing‐Olesen, B. Stevens   +2 more
semanticscholar   +1 more source