Results 1 to 10 of about 531,184 (380)

Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process

Frontiers in Cardiovascular Medicine, 2022
Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai, Cuicui Bai, Joke Konings, Joke Konings, Marisa Ninivaggi, Marcus Lancé, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +8 more
doaj   +1 more source

Reference values for thrombin dynamics in platelet rich plasma

Platelets, 2021
Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan, Marisa Ninivaggi, Bas de Laat, Romy M. W. de Laat-Kremers   +3 more
doaj   +1 more source

Bioinspired mechano-photonic artificial synapse based on graphene/MoS2 heterostructure

Science Advances, 2021
A bioinspired mechano-photonic artificial synapse with synergistic mechanical and optical plasticity is demonstrated. Developing multifunctional and diversified artificial neural systems to integrate multimodal plasticity, memory, and supervised learning
Jinran Yu, Xixi Yang, Guoyun Gao, Yao Xiong, Yifei Wang, Jing Han, Youhui Chen, Huai Zhang, Qijun Sun, Zhong Lin Wang   +9 more
semanticscholar   +1 more source

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Nature Aging, 2022
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, V. Gandham, Christopher M. Rose, C. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, R. Edmonds, A. De Mazière, Raphael Rakosi-Schmidt, T. Singh, J. Klumperman, O. Foreman, Michael C Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson   +21 more
semanticscholar   +1 more source

Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile

Frontiers in Cardiovascular Medicine, 2022
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li, Li Li, Mark Roest, Yaqiu Sang, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Dana Huskens, Jun Wan, Jun Wan, Bas de Laat, Bas de Laat, Joke Konings, Joke Konings   +15 more
doaj   +1 more source

ST Genesia reference values of 117 healthy donors measured with STG‐BleedScreen, STG‐DrugScreen and STG‐ThromboScreen reagents

Research and Practice in Thrombosis and Haemostasis, 2021
Introduction The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout the measurement.
Marisa Ninivaggi, Romy M. W. deLaat‐Kremers, Audrey Carlo, Bas deLaat   +3 more
doaj   +1 more source

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo, Qiuting Yan, Qiuting Yan, Hugo Ten Cate, Romy De Laat-Kremers, Romy De Laat-Kremers, Bas De Laat, Bas De Laat, Marisa Ninivaggi   +8 more
doaj   +1 more source

Combining human platelet proteomes and transcriptomes: possibilities and challenges

Platelets, 2023
The anucleate human platelets contain a broad pattern of mRNAs and other RNA transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from different sources points to a common origin, and suggests a random redistribution of ...
Jingnan Huang, Johan W.M. Heemskerk, Frauke Swieringa   +2 more
doaj   +1 more source

Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Nature Communications, 2021
The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia/macrophages and astrocytes are differentially involved in engulfing synapses
Xiaojing Shi, Long-long Luo, Jixian Wang, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon-Hyuk Lee, Hengli Tian, Zhi-jun Zhang, Yongting Wang, Won-Suk Chung, Yaohui Tang, Guo-Yuan Yang   +14 more
semanticscholar   +1 more source

The cell biology of synapse formation

Journal of Cell Biology, 2021
Thomas Südhof discusses the cell-biological principles underlying the assembly of specific synaptic connections with defined properties that control neural circuits.
T. Südhof
semanticscholar   +1 more source