Results 1 to 10 of about 449,578 (382)
Huntingtin and the Synapse [PDF]
Frontiers in Cellular Neuroscience, 2021 Huntington disease (HD) is a monogenic disease that results in a combination of motor, psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT).
Barron, Jessica C. +2 more
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The History of the Synapse [PDF]
The Anatomical Record, 2020 ABSTRACTWhy did I choose this particular topic for my lecture rather than the history of neuroscience or the history of the neuron? Simply because I believe that every disciple has the obligation to pay homage to their mentors once in their lifetime. My formation as a neuroscientist involved three such mentors spanned across three countries.
Constantino Sotelo, Constantino Sotelo
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Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process
Frontiers in Cardiovascular Medicine, 2022 Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai +8 more
doaj +1 more source
Reference values for thrombin dynamics in platelet rich plasma
Platelets, 2021 Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan +3 more
doaj +1 more source
Bioinspired mechano-photonic artificial synapse based on graphene/MoS2 heterostructure
Science Advances, 2021 A bioinspired mechano-photonic artificial synapse with synergistic mechanical and optical plasticity is demonstrated. Developing multifunctional and diversified artificial neural systems to integrate multimodal plasticity, memory, and supervised learning
Jinran Yu +9 more
semanticscholar +1 more source
Nature Aging, 2022 Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Borislav Dejanovic +21 more
semanticscholar +1 more source
Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile
Frontiers in Cardiovascular Medicine, 2022 BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li +15 more
doaj +1 more source
Neuron, 2013 The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements.
Daniel Choquet, Antoine Triller
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Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay
Frontiers in Cardiovascular Medicine, 2022 BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo +8 more
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Research and Practice in Thrombosis and Haemostasis, 2021 Introduction The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout the measurement.
Marisa Ninivaggi +3 more
doaj +1 more source