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Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process
Frontiers in Cardiovascular Medicine, 2022 Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai +8 more
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Reference values for thrombin dynamics in platelet rich plasma
Platelets, 2021 Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan +3 more
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Cell, 2004 The transmission of information across neuronal synapses is an energetically taxing business. Sheng and colleagues monitored the localization of mitochondria following different levels of synaptic activation and discovered that these organelles change their distribution in interesting ways, stalling near synapses when neurons are activated and ...
Schuman, E., Chan, D.
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Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile
Frontiers in Cardiovascular Medicine, 2022 BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li +15 more
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The Journal of Neuroscience, 1996 The strength of many synapses is modified by various use and time-dependent processes, including facilitation and depression. A general description of synaptic transfer characteristics must account for the history-dependence of synaptic efficacy and should be able to predict the postsynaptic response to any temporal pattern of presynaptic activity.
K, Sen +3 more
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Research and Practice in Thrombosis and Haemostasis, 2021 Introduction The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout the measurement.
Marisa Ninivaggi +3 more
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Combining human platelet proteomes and transcriptomes: possibilities and challenges
Platelets, 2023 The anucleate human platelets contain a broad pattern of mRNAs and other RNA transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from different sources points to a common origin, and suggests a random redistribution of ...
Jingnan Huang +2 more
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Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay
Frontiers in Cardiovascular Medicine, 2022 BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo +8 more
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Neuron, 2013 The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements.
Daniel Choquet, Antoine Triller
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TH Open, 2019 Introduction Although physical exercise is protective against cardiovascular disease, it can also provoke sudden cardiac death (exercise paradox).
Cécile H. Kicken +6 more
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