Synapse elimination and learning rules co-regulated by MHC class I H2-Db [PDF]
Nature, 2014 The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC)
Hanmi Lee +2 more
exaly +5 more sources
Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process
Frontiers in Cardiovascular Medicine, 2022 Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai +8 more
doaj +1 more source
Reference values for thrombin dynamics in platelet rich plasma
Platelets, 2021 Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan +3 more
doaj +1 more source
Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile
Frontiers in Cardiovascular Medicine, 2022 BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li +15 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2021 Introduction The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout the measurement.
Marisa Ninivaggi +3 more
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Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay
Frontiers in Cardiovascular Medicine, 2022 BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo +8 more
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Combining human platelet proteomes and transcriptomes: possibilities and challenges
Platelets, 2023 The anucleate human platelets contain a broad pattern of mRNAs and other RNA transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from different sources points to a common origin, and suggests a random redistribution of ...
Jingnan Huang +2 more
doaj +1 more source
cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]
, 2015 A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
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Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort
Frontiers in Cardiovascular Medicine, 2022 The coagulation system can be assessed by the thrombin generation (TG) assay, and increased TG peak height, endogenous thrombin potential (ETP), and velocity index are associated with an increased risk of thrombosis. Obesity had been reported to increase
Romy de Laat-Kremers +21 more
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Synaptic basis of a sub-second representation of time in a neural circuit model
Nature Communications, 2022 Neural circuit dynamics are thought to drive temporally precise actions. Here, the authors used a theoretical approach to show that synapses endowed with diverse short-term plasticity can act as tunable timers sufficient to generate rich neural dynamics.
A. Barri +3 more
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