Results 31 to 40 of about 421,951 (351)
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
Nature Communications, 2017 Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit ...
Yuko Tanabe +6 more
doaj +1 more source
eLife, 2020 In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne +2 more
doaj +1 more source
Activity-dependent regulation of mitochondrial motility in developing cortical dendrites
eLife, 2021 Developing neurons form synapses at a high rate. Synaptic transmission is very energy-demanding and likely requires ATP production by mitochondria nearby.
Catia AP Silva +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Thrombosis is a major clinical complication of COVID-19 infection. COVID-19 patients show changes in coagulation factors that indicate an important role for the coagulation system in the pathogenesis of COVID-19.
Romy de Laat-Kremers +8 more
doaj +1 more source
DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]
, 2019 T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
core +1 more source
Thrombin generation in low plasma volumes
Thrombosis Journal, 2018 Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.
Saartje Bloemen +2 more
doaj +1 more source
The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK [PDF]
, 2018 Upon engagement of the T cell receptor with an antigen-presenting cell, LCK initiates TCR signaling by phosphorylating its activation motifs. However, the mechanism of LCK activation specifically at the immune synapse is a major question.
Castro Sanchez, Patricia +6 more
core +1 more source
RNA, 2015 One reason we learn and remember is because synapses, the places where axons and dendrites meet, undergo experience-dependent changes whose long-lasting nature may underlie the formation and persistence of memory. Indeed, neurons use these morphological and biochemical alterations to distinguish experienced (i.e., stimulated) from naive (unstimulated ...
openaire +3 more sources
Identifiability of a Binomial Synapse [PDF]
Frontiers in Computational Neuroscience, 2020 Frontiers in Computational Neuroscience ...
Camille Gontier +2 more
openaire +5 more sources
Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. [PDF]
, 2018 The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity.
Bi, Guo-Qiang +4 more
core +2 more sources