Results 41 to 50 of about 421,951 (351)

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

TH Open
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation.
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa   +8 more
doaj   +1 more source

Correction to: Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

BMC Cancer, 2019
Following publication of the original article [1], the authors have re-evaluated the authorship for this article. The updated author group is:
Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im   +10 more
doaj   +1 more source

The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks

Frontiers in Neurology, 2022
The IMI public-private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA) was launched in 2008 with an initial budget of €2 billion.
Diana O'Rourke, Nina Coll-Padrós, Angela Bradshaw, Lewis Killin, Laurent Pradier, Jean Georges, Dalia M. Dawoud, Dalia M. Dawoud, Lennert Steukers, Carlos Diaz   +9 more
doaj   +1 more source

Synapse efficiency diverges due to synaptic pruning following over-growth

, 2003
In the development of the brain, it is known that synapses are pruned following over-growth. This pruning following over-growth seems to be a universal phenomenon that occurs in almost all areas -- visual cortex, motor area, association area, and so on ...
A.W. Roe, C.J. Perez-Vincente, D.J. Amit, D.J. Amit, G. Chechik, G.M. Innocenti, H. Sompolinsky, H. Yanai, I. Meilijson, J. Buhmann, J. Takacs, J.P. Bourgeois, J.R. Wolff, K. Mimura, K. Mimura, Kazushi Mimura, M. Griniasty, M. Okada, M. Okada, M. Okada, M. Shiino, M. Shiino, M.F. Eckenhoff, M.P. Stryker, M.V. Tsodyks, Masato Okada, P. Rakic, P.R. Huttenlocker, P.R. Huttenlocker, S. Amari, T. Kimoto, Tomoyuki Kimoto   +31 more
core   +1 more source

Proteomics of synapse [PDF]

Analytical and Bioanalytical Chemistry, 2006
Large-scale phosphoproteome analysis on synaptosome and preparation of post-synaptic density (PSD) were investigated. It was found that protein phosphor is a common event in the synapse, which is consistent with the presence of diverse classes of kinases and phosphatases in the synapse.
openaire   +4 more sources

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C

Frontiers in Cardiovascular Medicine
BackgroundThe mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.
Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +6 more
doaj   +1 more source

A one-transistor-synapse strategy for electrically-programmable massively-parallel analog array processors [PDF]

, 1997
This paper presents a linear, four-quadrants, electrically-programmable, one-transistor synapse strategy applicable to the implementation of general massively-parallel analog processors in CMOS technology.
Carmona Galán, Ricardo, Domínguez Castro, Rafael, Espejo Meana, Servando Carlos, Rodríguez Vázquez, Ángel Benito   +3 more
core   +1 more source

Abacavir use is associated with increased prothrombin conversion

Frontiers in Immunology, 2023
There is ongoing debate as to whether abacavir (ABC) increases the risk for cardiovascular disease(CVD) in people living with HIV (PLHIV) and the mechanisms underlying this possible association.
Qiuting Yan, Qiuting Yan, Shengshi Huang, Shengshi Huang, Wouter van der Heijden, Marisa Ninivaggi, Lisa van de Wijer, Romy de Laat-Kremers, Andre J. Van der Ven, Bas de Laat, Bas de Laat, Quirijn de Mast   +11 more
doaj   +1 more source

Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
core   +1 more source

A geographically distributed bio-hybrid neural network with memristive plasticity [PDF]

, 2017
Throughout evolution the brain has mastered the art of processing real-world inputs through networks of interlinked spiking neurons. Synapses have emerged as key elements that, owing to their plasticity, are merging neuron-to-neuron signalling with ...
Corna, Andrea, George, Richard, Indiveri, Giacomo, Khiat, Ali, Maschietto, Marta, Mayr, Chirstian, Prodromakis, Themistoklis, Reato, Marco, Rocchi, Federico, Serb, Alexantrou, Vassanelli, Stefano   +10 more
core   +1 more source