Results 61 to 70 of about 466,973 (293)
Cell-type specific innervation of cortical pyramidal cells at their apical dendrites
eLife, 2020 We investigated the synaptic innervation of apical dendrites of cortical pyramidal cells in a region between layers (L) 1 and 2 using 3-D electron microscopy applied to four cortical regions in mouse.
Ali Karimi +4 more
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Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]
, 2014 Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J +2 more
core +1 more source
Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord [PDF]
, 2009 Pure NMDA receptor (NMDAr)-mediated EPSCs, thought to correspond to "silent" glutamatergic synapses that lack AMPA receptors (AMPArs), have been observed in superficial spinal dorsal horn of neonatal but not adult rats.
Hughes, D.I. +6 more
core +3 more sources
Neuron, 2017 Synaptic communication requires alignment of transmitter release sites with transmitter receptors. In this issue of Neuron, Wang et al. (2017) show that α2δ4 subunits link calcium channels to a trans-synaptic complex with glutamate receptors at the visual system's first synapse.
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2017 Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system.
Rui P. A. Tan +2 more
doaj +1 more source
Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
Frontiers in Cellular Neuroscience, 2020 Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease ...
Catarina Perdigão +5 more
doaj +1 more source
Emulating long-term synaptic dynamics with memristive devices [PDF]
, 2016 The potential of memristive devices is often seeing in implementing neuromorphic architectures for achieving brain-like computation. However, the designing procedures do not allow for extended manipulation of the material, unlike CMOS technology, the ...
Berdan, Radu +5 more
core +2 more sources
Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
Neural Development, 2018 In the mammalian cerebral cortex neurons are arranged in specific layers and form connections both within the cortex and with other brain regions, thus forming a complex mesh of specialized synaptic connections comprising distinct circuits.
Isabella Farhy-Tselnicker, N. J. Allen
semanticscholar +1 more source
Journal of Experimental Biology, 1984 ABSTRACT‘Typically’ chemical synaptic transmission takes place when an influx of calcium ions during a presynaptic nerve impulse triggers exocytosis of neurotransmitter substance from synaptic vesicles. The neurotransmitter diffuses across the synaptic cleft and occupies receptors embedded in the subsynaptic membrane.
openaire +2 more sources
Advanced Electronic Materials, 2018 Employing flash memories that function as the analogue synapse cleft for implementation of neural systems is a popular approach. For practical application in synapse mimicking, ambipolar trapping of both holes and electrons enables the weight updated ...
Xiaoli Chen +9 more
doaj +1 more source