Results 91 to 100 of about 530,363 (319)

Exact firing-rate response of the integrate-and-fire neuron receiving finite amplitude excitatory and inhibitory post-synaptic potentials [PDF]

, 2011
Neurons in active networks are subject to a fluctuating synaptic drive comprising excitatory and inhibitory postsynaptic potentials arriving at high rates relative to the integration time of the cell.
Swarbrick, Rupert, Richardson, Magnus J. E., Richardson Magnus JE, Rupert Swarbrick, Swarbrick Rupert, Magnus JE Richardson   +5 more
core   +1 more source

Enhanced integration of newborn neurons after neonatal insults

Frontiers in Neuroscience, 2011
The production and integration of adult-generated neurons in the dentate gyrus is dramatically perturbed by a variety of pathological insults, including repetitive seizures and hypoxia/ischemia.
Phyllis C Pugh, Elena W Adlaf, Chaunsheng eZhao, Sean J Markwardt, Cristin F Gavin, Jacques I Wadiche, Linda eOverstreet-Wadiche   +6 more
doaj   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Isabel Dean, Frances A. Edwards, Dean, I., Susan J. Robertson, Edwards, F.A., Robertson, S.J.   +5 more
core   +1 more source

Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]

, 2012
Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Schmitt, L. Ian, R. E. Sims, Sims, Robert E., P. G. Haydon, Dale, Nicholas, Sims, Robert, Haydon, Philip G, L. I. Schmitt, N. Dale, Schmitt, L Ian   +9 more
core   +1 more source

Neurotrapping: cellular screens to identify the neural substrates of behavior in Drosophila

Frontiers in Molecular Neuroscience, 2009
The availability of new tools for manipulating neuronal activity, coupled with the development of increasingly sophisticated techniques for targeting these tools to subsets of cells in living, behaving animals, is permitting neuroscientists to tease ...
Benjamin H White, Nathan C Peabody
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory

Cell Reports, 2017
Histone deacetylases (HDACs) have been extensively studied as drug targets in neurodegenerative diseases, but less is known about their role in healthy neurons.
Sarah Perry, Beril Kiragasi, Dion Dickman, Anandasankar Ray   +3 more
doaj   +1 more source

Synaptic and Non-synaptic AMPA Receptors Permeable to Calcium

Japanese Journal of Pharmacology, 2001
For a long time, alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors permeable to calcium have been considered to be either non-existent or as "atypical". There is now ample evidence that these receptors exist in numerous regions of the nervous system and in many neuronal as well as non-neuronal cell populations.
König, Norbert, Poluch, Sylvie, Estabel, Jeanne, Durand, Micheline, Drian, Marie-Jeanne, Exbrayat, Jean-Marie   +5 more
openaire   +3 more sources

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source