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The dysconnection hypothesis of schizophrenia: a 30-year update. [PDF]
World PsychiatryFriston K.
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Editor's Note: Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease. [PDF]
Hum Mol Geneteuropepmc +1 more source
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Synaptic proteins and the assembly of synaptic junctions
Trends in Cell Biology, 1996Synapses are highly specialized contact sites between neurons and their target cells where information in the form of chemical substances travels from a pre- to a postsynaptic cell. In the central nervous system of mammals, most nerve cells are innervated by functionally distinct types of synapses, each requiring a specific set of molecular ...
C C, Garner, S, Kindler
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Nature, 2004
Neurons are often considered to be the computational engines of the brain, with synapses acting solely as conveyers of information. But the diverse types of synaptic plasticity and the range of timescales over which they operate suggest that synapses have a more active role in information processing.
L F, Abbott, Wade G, Regehr
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Neurons are often considered to be the computational engines of the brain, with synapses acting solely as conveyers of information. But the diverse types of synaptic plasticity and the range of timescales over which they operate suggest that synapses have a more active role in information processing.
L F, Abbott, Wade G, Regehr
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Nature Reviews Neuroscience, 2021
A mismatch between cell adhesion proteins at the mossy fibre synapse drives female-specific synaptic and cognitive dysfunction in a mouse model of developmental and epileptic encephalopathy 9.
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A mismatch between cell adhesion proteins at the mossy fibre synapse drives female-specific synaptic and cognitive dysfunction in a mouse model of developmental and epileptic encephalopathy 9.
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Cell and Tissue Research, 2014
Synapses are focal hot spots for signal transduction and plasticity in the brain. A synapse comprises an axon terminus, the presynapse, the synaptic cleft containing extracellular matrix proteins as well as adhesion molecules, and the postsynaptic density as target structure for chemical signaling.
Melanie, Laßek +2 more
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Synapses are focal hot spots for signal transduction and plasticity in the brain. A synapse comprises an axon terminus, the presynapse, the synaptic cleft containing extracellular matrix proteins as well as adhesion molecules, and the postsynaptic density as target structure for chemical signaling.
Melanie, Laßek +2 more
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Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
Science, 1993Complex brain functions, such as learning and memory, are believed to involve changes in the efficiency of communication between nerve cells. Therefore, the elucidation of the molecular mechanisms that regulate synaptic transmission, the process of intercellular communication, is an essential step toward understanding nervous system function.
GREENGARD P. +3 more
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Modulation of synaptic delay during synaptic plasticity
Trends in Neurosciences, 2002At most synapses, information about the processes underlying transmitter release evoked by a presynaptic action potential has been gathered indirectly, based on characterization of the postsynaptic response. Traditionally, the two electrophysiological parameters used for this indirect investigation are the amplitude and latency of the response.
Jen-Wei, Lin, Donald S, Faber
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