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Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity [PDF]

Cell, 2016
Postsynaptic densities (PSDs) are membrane semi-enclosed, submicron protein-enriched cellular compartments beneath postsynaptic membranes, which constantly exchange their components with bulk aqueous cytoplasm in synaptic spines. Formation and activity-dependent modulation of PSDs is considered as one of the most basic molecular events governing ...
Mingjie Zhang, Richard L. Huganir, Yoichi Araki   +2 more
exaly   +4 more sources

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The Maturation of Post-Synaptic Densities in Chicken Forebrain

Neuroscience Letters, 1984
During normal post-hatch development and maturation in chicken forebrain there was a doubling in the average thickness of the post-synaptic densities (PSDs) in isolated synaptosomes, but no change in the average length of synaptic junctions. In the same period the concentration of the major post-synaptic density protein ( mPSDp ) in membranes prepared ...
John A P Rostás, F H Güldner, J A Rostás   +2 more
exaly   +3 more sources

Effects of halothane on cerebral synaptic density

Experimental Neurology, 1980
Abstract A selected area of the superior sagittal cortex of 28 rats was examined for changes in synaptic density after chronic exposure to halothane. Rats were exposed to either 50, 100, or 200 ppm halothane from conception to 28 days of age. Synapses were stained with ethanolic phosphotungstic acid and morphometric measurement was carried out with a
E, Uemura, R E, Bowman
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In vivo evidence of lower synaptic vesicle density in schizophrenia

Molecular Psychiatry, 2021
Decreased synaptic spine density has been the most consistently reported postmortem finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle density estimated using the novel positron emission tomography (PET) ligand [11C]UCB-J is a proxy measure of synaptic density. In this study we determined whether [11C]UCB-J binding,
Rajiv Radhakrishnan, Patrick D. Skosnik, Mohini Ranganathan, Mika Naganawa, Takuya Toyonaga, Sjoerd Finnema, Ansel T. Hillmer, Irina Esterlis, Yiyun Huang, Nabeel Nabulsi, Richard E. Carson, Deepak C. D’Souza   +11 more
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Astrocytes play a role in regulation of synaptic density

Brain Research, 1987
Exposure of neonatal cerebellar explants to cytosine arabinoside destroys granule cells and arrests surviving glia in an early stage of maturation. Purkinje cells lack astroglial ensheathment and are hyperinnervated by sprouted Purkinje cell recurrent axon collateral terminals.
C K, Meshul, F J, Seil, R M, Herndon
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Imaging synaptic density in the living human brain

Science Translational Medicine, 2016
Synaptic density in the living human brain was measured with positron emission tomography and a synaptic vesicle glycoprotein 2A tracer.
Sjoerd J, Finnema, Nabeel B, Nabulsi, Tore, Eid, Kamil, Detyniecki, Shu-Fei, Lin, Ming-Kai, Chen, Roni, Dhaher, David, Matuskey, Evan, Baum, Daniel, Holden, Dennis D, Spencer, Joël, Mercier, Jonas, Hannestad, Yiyun, Huang, Richard E, Carson   +14 more
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Quantitative Assessment of Cortical Synaptic Density in Alzheimer's Disease

Neurobiology of Aging, 1990
Significant progress has been made over the last decade in delineating the neuropathological and neurochemical changes in the brains of patients with Alzheimer's disease (AD). Less well studied are the actual synaptic connections of affected areas of the brain, such as the cerebral cortex. Because the final common pathway for neurotransmission involves
Steven T. DeKosky, Stephen W Scheff
exaly   +3 more sources

A method for demonstration of synaptic densities in CNS

Histochemistry, 1975
The synaptic densities in rat CNS were demonstrated using an alcohol solution of uranyl acetate at pH 5.0-6.0 of unosmicated material. A number of procedures were performed to establish the chemical characteristics of the structures stained by the method described.
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Impact of electrolyte density on synaptic characteristics of oxygen-based ionic synaptic transistor

Applied Physics Letters, 2021
An oxygen-based ionic synaptic transistor (O-IST) is a promising synaptic element for neuromorphic computing. In this study, we demonstrated that the density of the electrolyte plays a key role in achieving excellent synaptic characteristics in an O-IST.
Chuljun Lee, Wooseok Choi, Myunghoon Kwak, Seyoung Kim, Hyunsang Hwang   +4 more
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