Results 251 to 260 of about 2,928,945 (285)

The cytochemistry of synaptic densities. II. Proteinaceous components and mechanism of synaptic connectivity

Journal of Ultrastructure Research, 1971
The effect of enzymatic digestion on the staining of synapses with the bismuth iodide technique (BIUL) has been investigated. Trypsin, chymotrypsin, and peptidases had only little effect on BIUL-positive material of the synapse, whereas they prevented uranyl and lead staining of the membrane complexes.
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Synaptic metaplasticity and the local charge effect in postsynaptic densities

Trends in Neurosciences, 1998
Synaptic plasticity might be one of the elementary processes that underlies higher brain functions, such as learning and memory. Intriguingly, the capacity of a synapse for plastic changes itself displays marked variation or plasticity. This higher-order plasticity, or metaplasticity, appears to depend on the same macromolecules as plasticity, most ...
P, Tompa, P, Friedrich
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Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease

Molecular Psychiatry
The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography (PET) and plasma analysis in Alzheimer's disease (AD) patients are unknown. Seventy-five participants, including 26 AD patients, 19 mild cognitive impairment (MCI) patients, and 30 normal controls (NCs), underwent [18F]SynVesT-1 PET/MR scans
Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Yiyun Huang, Yang Yang, Zengping Lin, Tengfei Guo, Jun Zhao, Yihui Guan, Binyin Li, Fang Xie   +13 more
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Synaptic density in chronic animals with experimental neurofibrillary changes

Experimental Neurology, 1984
Synaptic density was quantitated in the cerebral cortex and subiculum of rabbits with experimental neurofibrillary changes. Animals were subjected to subcutaneous injection of aluminum tartrate for 90 days, and synapses stained with ethanolic phosphotungstic acid were analyzed in animals killed 100, 200, or 300 days postinjection with aluminum tartrate.
E, Uemura, W P, Ireland
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Comparison Between Synaptic and Neuronal Density

1991
The average number of synapses per neuron is a value which gains importance in theoretical considerations about cortical function. It reveals the maximum possible degree of dispersion of the signals emanating from one neuron, or conversely, the maximal possible convergence of signals from different sources onto one neuron.
Valentino Braitenberg, Almut Schüz
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Establishment of normal synaptic density in deafferented olfactory cortex

Brain Research, 1981
The piriform cortex has been examined in rats following neonatal deafferentation produced by olfactory bulb removal. The denervated molecular layer of the piriform cortex grows to nearly its full adult thickness and the removal olfactory bulb axons are replaced by intracortical axons.
B, Friedman, J L, Price
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Predicting protein–protein interactions in the post synaptic density

Molecular and Cellular Neuroscience, 2013
The post synaptic density (PSD) is a specialization of the cytoskeleton at the synaptic junction, composed of hundreds of different proteins. Characterizing the protein components of the PSD and their interactions can help elucidate the mechanism of long-term changes in synaptic plasticity, which underlie learning and memory.
Ossnat Bar-shira, Gal Chechik
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Molecular Composition of Synaptic Junctions and Post-Synaptic Densities: A Functional Perspective

1982
The development of subcellular methods to isolate central nervous system synapses and their subcomponents has made it possible to carry out detailed chemical analysis and to examine the capacities of the constituent molecules. The data gathered on the molecular structure and composition of synapses are making it possible to gain new insights into ...
C. W. Cotman, E. E. Mena, M. Nieto Sampedro   +2 more
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Signaling Proteins in the Post-Synaptic Density

2010
The ability of an organism to respond to its environment stems from synapses and signaling in the post-synaptic density (PSD). Neurological disorders often occur at the level of faulty signal transduction in the PSD. Here we describe the behavioral characterization of Densin 180, a PSD-enriched scaffold protein.
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Intracellularly Injected Cobaltous Ions Accumulate at Synaptic Densities

Science, 1980
Physiologically identified neurons in the locust were iontophoretically injected with a mixture of cobaltous and potassium ions. After being fixed for electron microscopy, 2.5-micrometer sections of the epoxy-embedded ganglia were intensified with silver. The intensified material was resectioned and examined in the electron microscope.
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