Results 41 to 50 of about 2,725,603 (391)
The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area. [PDF]
, 2016 Chemokines have several physio-pathological roles in the brain. Among them, the modulation of synaptic contacts and neurotransmission recently emerged as crucial activities during brain development, in adulthood, upon neuroinflammation and ...
DI CASTRO, MARIA AMALIA +5 more
core +1 more source
Signal Reception With Generic Three-State Receptors in Synaptic MC [PDF]
, 2022 Synaptic communication is studied by communication engineers for two main reasons. One is to enable novel neuroengineering applications that require interfacing with neurons. The other reason is to draw inspiration for the design of synthetic molecular communication systems.
arxiv +1 more source
eLife, 2021 The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders.
Kang-Ying Qian +15 more
doaj +1 more source
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
A computational model for synaptic message transmission [PDF]
arXiv, 2023 A computational model incorporating insights from quantum theory is proposed to describe and explain synaptic message transmission. We propose that together, neurotransmitters and their corresponding receptors, function as a physical "quantum decision tree" to "decide" whether to excite or inhibit the synapse.
arxiv
PLoS ONE, 2010 Methamphetamine (METH) is an addictive psychostimulant whose societal impact is on the rise. Emerging evidence suggests that psychostimulants alter synaptic plasticity in the brain--which may partly account for their adverse effects.
Jarod Swant +3 more
doaj +1 more source
Phenomenological modeling of diverse and heterogeneous synaptic dynamics at natural density [PDF]
, 2022 This chapter sheds light on the synaptic organization of the brain from the perspective of computational neuroscience. It provides an introductory overview on how to account for empirical data in mathematical models, implement such models in software, and perform simulations reflecting experiments.
arxiv +1 more source
Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity
Frontiers in Synaptic Neuroscience, 2019 The numbers and strengths of synapses in the brain change throughout development, and even into adulthood, as synaptic inputs are added, eliminated, and refined in response to ongoing neural activity.
S. Glasgow +4 more
semanticscholar +1 more source
Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]
, 2011 Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena +5 more
core +1 more source
Metabolic constraints on synaptic learning and memory [PDF]
Journal of Neurophysiology 122: 1473-1490 (2019), 2019 Dendritic spines, the carriers of long-term memory, occupy a small fraction of cortical space, and yet they are the major consumers of brain metabolic energy. What fraction of this energy goes for synaptic plasticity, correlated with learning and memory?
arxiv +1 more source