Results 41 to 50 of about 2,697,657 (391)
Stochastic lattice model of synaptic membrane protein domains [PDF]
Phys. Rev. E 95, 052406 (2017), 2017 Neurotransmitter receptor molecules, concentrated in synaptic membrane domains along with scaffolds and other kinds of proteins, are crucial for signal transmission across chemical synapses. In common with other membrane protein domains, synaptic domains are characterized by low protein copy numbers and protein crowding, with rapid stochastic turnover ...
arxiv +1 more source
Molecular Noise In Synaptic Communication [PDF]
, 2022 In synaptic molecular communication (MC), the activation of postsynaptic receptors by neurotransmitters (NTs) is governed by a stochastic reaction-diffusion process. This randomness of synaptic MC contributes to the randomness of the electrochemical downstream signal in the postsynaptic cell, called postsynaptic membrane potential (PSP).
arxiv +1 more source
The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area. [PDF]
, 2016 Chemokines have several physio-pathological roles in the brain. Among them, the modulation of synaptic contacts and neurotransmission recently emerged as crucial activities during brain development, in adulthood, upon neuroinflammation and ...
DI CASTRO, MARIA AMALIA +5 more
core +1 more source
Turbocharging synaptic transmission
FEBS Letters, 2023 Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission. Recent direct measurements in cell‐free systems suggest there are 12 SNAREpins in each ready‐release vesicle, consisting of six ...
James E. Rothman +3 more
openaire +2 more sources
Signal Reception With Generic Three-State Receptors in Synaptic MC [PDF]
, 2022 Synaptic communication is studied by communication engineers for two main reasons. One is to enable novel neuroengineering applications that require interfacing with neurons. The other reason is to draw inspiration for the design of synthetic molecular communication systems.
arxiv +1 more source
Gain modulation of synaptic inputs by network state in auditory cortex in vivo [PDF]
, 2015 The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia.
Destexhe, Alain +4 more
core +3 more sources
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity
Frontiers in Synaptic Neuroscience, 2019 The numbers and strengths of synapses in the brain change throughout development, and even into adulthood, as synaptic inputs are added, eliminated, and refined in response to ongoing neural activity.
S. Glasgow +4 more
semanticscholar +1 more source
eLife, 2021 The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders.
Kang-Ying Qian +15 more
doaj +1 more source
A computational model for synaptic message transmission [PDF]
arXiv, 2023 A computational model incorporating insights from quantum theory is proposed to describe and explain synaptic message transmission. We propose that together, neurotransmitters and their corresponding receptors, function as a physical "quantum decision tree" to "decide" whether to excite or inhibit the synapse.
arxiv