Results 91 to 100 of about 539,046 (150)

The Effect of Co-Administration of Levetiracetam or Brivaracetam with Ethanol on the Associative Learning and Anxiety Level of Rats

Future Pharmacology
Background: Ethanol intake leads to cognitive deficits. Recent research demonstrated that a dysregulation of synaptic vesicle glycoprotein 2A (SV2A) expression seems to be linked to anxiety and memory disorders.
Ewa Zwierzyńska, Bogusława Pietrzak
doaj   +1 more source

Synaptic loss and its association with symptom severity in Parkinson’s disease

npj Parkinson's Disease
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD and other ...
Sophie E. Holmes, Praveen Honhar, Sule Tinaz, Mika Naganawa, Ansel T. Hilmer, Jean-Dominique Gallezot, Mark Dias, Yanghong Yang, Takuya Toyonaga, Irina Esterlis, Adam Mecca, Christopher Van Dyck, Shannan Henry, Jim Ropchan, Nabeel Nabulsi, Elan D. Louis, Robert Comley, Sjoerd J. Finnema, Richard E. Carson, David Matuskey   +19 more
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Kinetic evaluation and test–retest reproducibility of [¹¹C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans

, 2017
Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test–retest reproducibility assessment of the SV2A positron emission tomography (PET) radioligand [11C]UCB-J in humans.
Ming-Kai Chen, David Matuskey, Jean-Dominique Gallezot, Joël Mercier, Nabeel B Nabulsi, Shannan Henry, Richard E Carson, Yiyun Huang, Jonas Hannestad, Shu-fei Lin, Sjoerd J Finnema   +10 more
core   +1 more source

Synaptic Terminal Density Early in the Course of Schizophrenia: an in vivo UCB-J Positron Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A (SV2A)

BackgroundThe synaptic hypothesis is an influential theory of the pathoetiology of schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the synaptic terminal density marker [11C]UCB-J in patients with chronic SCZ than in control participants.
Onwordi, Ellis Chika, Whitehurst, Thomas, Shatalina, Ekaterina, Mansur, Ayla, Arumuham, Atheeshaan, Osugo, Martin, Reis Marques, Tiago, Jauhar, Sameer, Gupta, Susham, Mehrotra, Ravi, Rabiner, Eugenii A., Gunn, Roger N., Natesan, Sridhar, Howes, Oliver   +13 more
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A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease

Alzheimer’s Research & Therapy
Background Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ oligomers are among the most toxic ...
Christopher H. van Dyck, Adam P. Mecca, Ryan S. O’Dell, Hugh H. Bartlett, Nina G. Diepenbrock, Yiyun Huang, Mary E. Hamby, Michael Grundman, Susan M. Catalano, Anthony O. Caggiano, Richard E. Carson   +10 more
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An In Vivo High-Resolution Human Brain Atlas of Synaptic Density

Synapses are fundamental to the function of the central nervous system and are implicated in a number of brain disorders. Despite their pivotal role, a comprehensive imaging resource detailing the distribution of synapses in the human brain has been ...
Raval, Nakul Ravi, Raval, NR, Gillings, N, Colliander, Emil, Plavén-Sigray, Pontus, Colliander, E, Plaven-Sigray, P, Svarer, C, Svarer, Claus, Beliveau, V, Beliveau, Vincent, Dam, Vibeke Høyrup, Dam, VH, Knudsen, GM, Johansen, Annette, Gillings, Nic, Aznar, S, Aznar, Susana, Knudsen, Gitte Moos, Johansen, A   +19 more
core   +1 more source

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

Alzheimer’s Research & Therapy
Background The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD).
Elaheh Salardini, Ryan S. O’Dell, Em Tchorz, Nabeel B. Nabulsi, Yiyun Huang, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca   +7 more
doaj   +1 more source

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission
Synaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. SV2A also serves as a specific binding site for certain antiepileptics and is implicated in the treatment of epilepsy.
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The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance.

, 2019
The synaptic vesicle glycoprotein 2 (SV2) family is comprised of three paralogues: SV2A, SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every secretory vesicle, including synaptic vesicles, and are critical to ...
Stout, Kristen A, Miller, Gary W, Dunn, Amy R, Hoffman, Carlie   +3 more
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Multidimensional Profiling of Senescence in Eastern Honey Bee, Apis cerana (Hymenoptera: Apidae), Workers: Morphology, Microstructure, and Transcriptomics

Insects
Worker honey bees are crucial for colony stability and ecosystem pollination. However, the cross-scale aging features and underlying mechanisms in the Eastern honey bee (Apis cerana) remain poorly understood.
Qiang Ma, Zachary Y. Huang, Qianmin Hai, Jun Zhang, Xiangyou Tang, Xiaoqun Dang, Jinshan Xu, Zhengang Ma, Zeyang Zhou   +8 more
doaj   +1 more source