Results 101 to 110 of about 539,046 (150)

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

, 2006
Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by selectively cleaving core components of the vesicular fusion machinery. The synaptic vesicle proteins Synaptotagmin-I and -II act as receptors for BoNT/B and BoNT/G. Here we show that BoNT/
Mahrhold, Stefan, Davletov, Bazbek, Binz, Thomas, Rummel, Andreas, Bigalke, Hans   +4 more
core   +1 more source

Imaging synaptic density in the living human brain

, 2016
Chemical synapses are the predominant neuron-to-neuron contact in the central nervous system. Presynaptic boutons of neurons contain hundreds of vesicles filled with neurotransmitters, the diffusible signaling chemicals. Changes in the number of synapses
Lin, Shu-Fei, Huang, Yiyun, Dhaher, Roni, Matuskey, David, Eid, Tore, Finnema, Sjoerd J, Spencer, Dennis D, Mercier, Joël, Nabulsi, Nabeel B, Carson, Richard E, Hannestad, Jonas, Chen, Ming-Kai, Baum, Evan, Detyniecki, Kamil, Holden, Daniel   +14 more
core   +1 more source

Effects of cognitive training under hypoxia on cognitive proficiency and neuroplasticity in remitted patients with mood disorders and healthy individuals: ALTIBRAIN study protocol for a randomized controlled trial

Trials
Background Cognitive impairment is prevalent across neuropsychiatric disorders but there is a lack of treatment strategies with robust, enduring effects.
Kamilla Woznica Miskowiak, Viktoria Damgaard, Johanna Mariegaard Schandorff, Julian Macoveanu, Gitte Moos Knudsen, Annette Johansen, Pontus Plaven-Sigray, Claus Svarer, Caroline Bruun Fussing, Katrine Cramer, Martin Balslev Jørgensen, Lars Vedel Kessing, Hannelore Ehrenreich   +12 more
doaj   +1 more source

Neuronal differentiation of human dental pulp stem cells induced by co-treatment of ergothioneine.

PLoS ONE
ObjectiveHuman dental pulp stem cells (hDPSCs) are promising adult stem cells that present multilineage differentiation ability. Interestingly, ergothioneine (ERGO) has the potential to uptake into the organic cation transporter N1 (OCTN1) to promote ...
Amarin Thongsuk, Peeratchai Seemaung, Phetcharat Phanthong, Kajohnkiart Janebodin, Nisarat Ruangsawasdi, Thanasup Gonmanee, Chareerut Phruksaniyom, Tarinee Chodchavanchai, Tatcha Balit, Kenneth L White, Charoensri Thonabulsombat, Anupong Thongklam Songsaad   +11 more
doaj   +1 more source

A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release

A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release
Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2a[L174Q] rat) carrying a missense mutation of the Sv2a gene and ...
openaire   +1 more source

SV2A Synapse Diversity Project

An analysis of the expression of SV2A in human and mouse brain synapsesSynapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients.
School of Regeneration and Repair, Edinburgh Neuroscience, Grant, Seth, Centre for Clinical Brain Sciences   +3 more
core  

Higher level of [³H]UCB-J binding in ApoE Ɛ4 allele carriers with Alzheimer disease

Neuronal and synapse losses are seen under the progression of Alzheimer’s disease (AD). Accordingly, the binding to the synaptic vesicle glycoprotein 2A (SV2A) using the selective radioligand [3H]UCB-J was found to be reduced in frontal cortex from ...
Pazarlar, Burcu A., Mikkelsen, Jens D., Linde-Atkins, Phoebe   +2 more
core   +1 more source

Mapping the Synaptome in Neurodegeneration: Emerging Clinical Applications of SV2A PET Imaging. [PDF]

Mol Diagn Ther
Filippi L, Nuvoli S, Spanu A, Palumbo B.
europepmc   +1 more source

Sleep differentially modulates synaptic vesicle protein 2A and spine density across cortical regions and development. [PDF]

iScience
Ma J, Braun A, Oskamp A, Kricsfalussy-Hrabár L, Hermes N, Djakkani S, Holz U, Jakobs S, Klein S, Stüsgen S, Krapf P, Neumaier B, Drzezga A, Beer S, Bauer A, Rollenhagen A, Kampa B, Elmenhorst D.   +17 more
europepmc   +1 more source

Detection of Focal Lesions in Epilepsy with [¹⁸F]UCB-H Synaptic Vesicle Protein 2A PET Imaging. [PDF]

J Nucl Med
Pakula V, Dorneich JS, Frontzkowski L, Bartos LM, Fearns N, Roemer-Cassiano SN, Lindner S, Zwergal A, Kaufmann E, Höglinger G, Franzmeier N, Werner RA, Vollmar C, Rémi J, Brendel M, Gnörich J.   +15 more
europepmc   +1 more source