Results 81 to 90 of about 539,046 (150)

Dose reduction for synaptic density PET imaging in Parkinson’s disease

NeuroImage
Objective: Dynamic PET imaging with 11C-UCB-J enables in vivo quantification of synaptic vesicle glycoprotein 2A (SV2A), with prior reports of lower synaptic density in areas such as the brainstem nuclei and substantia nigra (SN) in Parkinson’s disease ...
Andi Li, Mika Naganawa, Praveen Honhar, Kathryn Fontaine, Paul Gravel, David Matuskey, Richard E. Carson, Jing Tang   +7 more
doaj   +1 more source

SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling [PDF]

Following exocytosis, the recapture of plasma membrane-stranded vesicular proteins into recycling synaptic vesicles (SVs) is essential for sustaining neurotransmission. Surface clustering of vesicular proteins has been proposed to act as a ‘pre-assembly’
Jiang, Anmin, Kontaxi, Christiana, Small, Christopher, Martínez‐mármol, Ramón, Malapaka, Anusha, Gormal, Rachel S., Pronot, Marie, Joensuu, Merja, Harper, Callista, Davenport, Elizabeth C.; id_orcid, Cousin, Michael A.; id_orcid, Yak, Nyakuoy, Meunier, Frédéric A., Wallis, Tristan P.   +13 more
core   +1 more source

Levetiracetam Effect on Hematological Indices in children with Idiopathic Epilepsy [PDF]

Zagazig University Medical Journal
Background: Levetiracetam (LEV) is a well-known broad-spectrum antiepileptic drug, approved by FDA, for proper and effective control of both focal and generalized epilepsy.
Eman Abdel Hady, Safaa Ahmed, Abdallah Abd el hameed, Ghada Hegazy, Seham Ibrahim   +4 more
doaj   +1 more source

Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and StructureActivity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones

, 2021
A series of synaptic vesicle protein 2A (SV2A) ligands were synthesized to explore the structure–activity relationship and to help further investigate a hydrogen bonding pharmacophore hypothesis.
Marcel Lindemann, Zhengxin Cai (1328304), Jie Tong (750316), Sjoerd J. Finnema, Songye Li, Jie Tong, Chao Zheng, Songye Li (3227994), Sjoerd J. Finnema (1408846), Yiyun Huang (2563660), Zhengxin Cai, Kyle C. Wilcox, Yiyun Huang, Richard Pracitto, Marcel Lindemann (8399940), Chao Zheng (728465), Kyle C. Wilcox (732676), Richard Pracitto (3228000)   +17 more
core   +1 more source

Validation, kinetic modeling, and test-retest reproducibility of [\ub9\u2078F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice

, 2022
: Alterations in synaptic vesicle glycoprotein 2\u2009A (SV2A) have been associated with several neuropsychiatric and neurodegenerative disorders.
De Lombaerde, Stef, Dominguez, Celia, Bard, Jonathan, Stroobants, Sigrid, Munoz-Sanjuan, Ignacio, Verhaeghe, Jeroen, Staelens, Steven, Liu, Longbin, Wang, Yuchuan, Bertoglio, Daniele, Zajicek, Franziska, Miranda, Alan, Lombaerde, Stef De, Franziska Zajicek, Yuchuan Wang, Stef De Lombaerde, Jeroen Verhaeghe, Jonathan Bard, Alan Miranda, Steven Staelens, Celia Dominguez, Longbin Liu, Sigrid Stroobants, Daniele Bertoglio, Ignacio Munoz-Sanjuan   +24 more
core   +1 more source

Synaptic expression of SV2A in mouse and human brain

Synapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients.
Tavares, Adriana, Cerebrovascular Research Group, School of Regeneration and Repair, Edinburgh Neuroscience, Grant, Seth, Qiu, Zhen, Notman, Beverly, Centre for Clinical Brain Sciences, Smith, Colin; id_orcid, Wong, Theresa   +9 more
core   +1 more source

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

Scientific Reports, 2018
This report demonstrates insoluble alpha-synuclein (aSYN)+ aggregates in human sporadic Parkinson’s disease (PD) midbrain that are linearly correlated with loss of glucocerebrosidase (GCase) activity.
Oeystein R. Brekk, Alyssa Moskites, Ole Isacson, Penelope J. Hallett   +3 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A)

Brivaracetam (BRV) and levetiracetam (LEV) are antiseizure medications (ASMs); UCB-J is a PET tracer targeting synaptic vesicle protein 2A (SV2A); UCB7361 is closely related to padsevonil, an experimental anticonvulsant; while UCB1244283 acts as an ...
Wolff, Christian, Martin, Matthew F., Hall, Adrian, Ledecq, Marie, Gillard, Michel, Provins, Laurent, Horanyi, Peter S., Coleman, Jonathan A., Mittal, Anshumali   +8 more
core   +1 more source

SV2A is expressed in subpopulations of mouse and human synapses

Synapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients.
Tavares, Adriana, Grant, Seth GN, Qiu, Zhen, Smith, Colin, Notman, Beverly, Wong, Theresa   +5 more
core   +2 more sources