Results 11 to 20 of about 3,985,879 (249)

Synaptic Vesicle Glycoprotein 2A: Features and Functions

Frontiers in Neuroscience, 2022
In recent years, the field of neuroimaging dramatically moved forward by means of the expeditious development of specific radioligands of novel targets.
Rachele Rossi, Rachele Rossi, Shokouh Arjmand, Simone Larsen Bærentzen, Simone Larsen Bærentzen, Albert Gjedde, Albert Gjedde, Albert Gjedde, Anne M. Landau, Anne M. Landau   +9 more
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Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure-Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones. [PDF]

ACS Omega, 2021
A series of synaptic vesicle protein 2A (SV2A) ligands were synthesized to explore the structure–activity relationship and to help further investigate a hydrogen bonding pharmacophore hypothesis.
Pracitto R, Wilcox KC, Lindemann M, Tong J, Zheng C, Li S, Finnema SJ, Huang Y, Cai Z.   +8 more
europepmc   +2 more sources

Measuring brain synaptic vesicle protein 2A with positron emission tomography and [¹⁸F]UCB-H. [PDF]

Alzheimers Dement (N Y), 2017
peer reviewedIntroduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET).
Bahri MA, Plenevaux A, Aerts J, Bastin C, Becker G, Mercier J, Valade A, Buchanan T, Mestdagh N, Ledoux D, Seret A, Luxen A, Salmon E.   +12 more
europepmc   +2 more sources

Synaptic vesicle protein 2A as a potential biomarker in synaptopathies [PDF]

, 2019
Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in ...
Blennow, Kaj,, Zimmer, ER, Heurling, K, Leuzy, Antoine,, Blennow, K, Zimmer, Eduardo R.,, Eriksson, Jonas,, Ashton, NJ, Lubberink, M, Lubberink, Mark, Lubberink, Mark,, Ashton, Nicholas J.,, Schöll, Michael, Leuzy, Antoine, Heurling, Kerstin, Ashton, Nicholas J, Zetterberg, H, Schöll, M, Zimmer, Eduardo R., Zetterberg, Henrik,, Zetterberg, Henrik, Eriksson, J, Heurling, Kerstin,, Leuzy, A, Schöll, Michael,, Blennow, Kaj, Eriksson, Jonas, Zimmer, Eduardo R, Lund University., Ashton, Nicholas J.   +29 more
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Munc 18-1 Protein Molecules Move between Membrane Molecular Depots Distinct from Vesicle Docking Sites [PDF]

, 2013
Four evolutionarily conserved proteins are required for mammalian regulated exocytosis: three SNARE proteins, syntaxin, SNAP-25, and synaptobrevin, and the SM protein, Munc18-1. Here, using single-molecule imaging, we measured the spatial distribution of
Rickman, Colin, Lu, Weiping, Yang, Lei, Hamilton, Charlotte, Smyth, Annya M., Cousin, Michael A., Rickman, Colin; id_orcid, Martin, Kirsty J., Duncan, Rory R., Cousin, Michael A.; id_orcid   +9 more
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11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies

European Journal of Hybrid Imaging, 2020
Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission
Nicolas Nicastro, Negin Holland, George Savulich, Stephen F. Carter, Elijah Mak, Young T. Hong, Selena Milicevic Sephton, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe, John T. O’Brien   +10 more
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Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
M. Gratzl, Grabs, D., Fox, P. A., M. Brich, Brich, M., D. Grabs, M. Bergmann, Bergmann, M., Gratzl, Manfred, Schuster, Th., Th. Schuster, P. A. Fox   +11 more
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Imaging Synaptic Density: The Next Holy Grail of Neuroscience?

Frontiers in Neuroscience, 2022
The brain is the central and most complex organ in the nervous system, comprising billions of neurons that constantly communicate through trillions of connections called synapses.
Maria Elisa Serrano, Maria Elisa Serrano, Eugene Kim, Eugene Kim, Marija M. Petrinovic, Marija M. Petrinovic, Federico Turkheimer, Diana Cash, Diana Cash   +8 more
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Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]

, 2012
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J., Martina Kurejova, Thomas Kuner, Irmgard Tegeder (179372), Hu, S.J., Kurejova Martina, Bali, K.K., Agarwal, Nitin, Anke Tappe-Theodor, Bali, Kiran Kumar, Polgar Erika, Franz Hofmann (179398), Todd, A.J., Lewin, G., Kuner Thomas, Ceng Luo (179354), Feil, Robert, Jens Schlossmann, Polgar, E., Gangadharan Vijayan, Andrew J Todd, Kurejova, Martina, Feil, Susanne, Ceng Luo, Hu, S., Susanne Feil (179376), Andrew J. Todd (179384), Feil, R., Rohini Kuner (179428), Erika Polgar (5649442), Rohini Kuner, Hu, San-Jue, Liu Da-Lu, Liu, D., Kuner, Thomas, San-Jue Hu (179417), Feil, S., Tegeder, Irmgard, Tappe-Theodor Anke, Kuner, R., Nitin Agarwal (179363), Robert Feil (28669), Agarwal, N., Agarwal Nitin, Xie, R.G., Robert Feil, Kiran Kumar Bali (179358), Da-Lu Liu (179408), Erika Polgar, Kuner, T., Tappe, Anke, Gary Lewin (179380), Liu, Da-Lu, Xie, R. G., Jens Schlossmann (179389), Nitin Agarwal, Luo, Ceng, Luo, C., Vijayan Gangadharan, Hu, S. J., Xie, Rou-Gang, Hofmann Franz, Da-Lu Liu, Rou-Gang Xie (179362), Bali Kiran Kumar, Tappe-Theodor, A., Kuner, Rohini, Lewin Gary, Liu, D. L., Kiran Kumar Bali, Irmgard Tegeder, Polgár, Erika, Hofmann, Franz, Tegeder Irmgard, Vijayan Gangadharan (179356), Rou-Gang Xie, Schlossmann Jens, Franz Hofmann, Feil Susanne, Hu San-Jue, San-Jue Hu, Xie Rou-Gang, Gangadharan, Vijayan, Todd Andrew J., Feil Robert, Martina Kurejova (179365), Bali, K. K., Gary Lewin, Susanne Feil, Anke Tappe-Theodor (179367), Lewin, Gary R., Schlossmann, Jens, Liu, D.L., Thomas Kuner (162293), Schlossmann, J., Luo Ceng, Gangadharan, V., Hofmann, F., Kuner Rohini, Todd, Andrew J., Xie, R., Tegeder, I., Kurejova, M., Luo, C;Gangadharan, V;Bali, KK;Xie, RG;Agarwal, N;Kurejova, M;Tappe-Theodor, A;Tegeder, I;Feil, S;Lewin, G;Polgar, E;Todd, AJ;Schlossmann, J;Hofmann, F;Liu, DL;Hu, SJ;Feil, R;Kuner, T;Kuner, R   +103 more
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Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis

NeuroImage, 2021
Background: The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations.
Xiaotian T. Fang, Takuya Toyonaga, Ansel T. Hillmer, David Matuskey, Sophie E. Holmes, Rajiv Radhakrishnan, Adam P. Mecca, Christopher H. van Dyck, Deepak Cyril D'Souza, Irina Esterlis, Patrick D. Worhunsky, Richard E. Carson   +11 more
doaj   +1 more source