Results 21 to 30 of about 3,985,879 (249)

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers. [PDF]

, 2013
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-
Eckhard Wolf, Pier Paolo Di Fiore, Treise, Irina, Helmut Fuchs, Offenhäuser, Nina, Simona Ronzoni, Thure Adler, Irina Treise, Betsholtz, Christer, Di Fiore, Pier Paolo, Busch, Dirk H., Martin Hrabě de Angelis, Lucano, Caterina, Amodio, Stefania, Adler, Thure, Caterina Lucano, Nina Offenhäuser, Betsholtz, Ingrid Holmberg, Rathkolb, Birgit, Pozzi, Benedetta, Daniela Castelletti, Castelletti, Daniela, Dirk H. Busch, Anna Sciullo, Ingrid Holmberg Betsholtz, Ronzoni, Simona, Christer Betsholtz, Stefano Casola, Birgit Rathkolb, Benedetta Pozzi, Sciullo, Anna, Fuchs, Helmut, Wolf, Eckhard, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Valérie Gailus-Durner, Casola, Stefano, Stefania Amodio   +37 more
core   +1 more source

AU-Neurophysics-Lab/Recycled-Synaptic-Vesicle-ISVE-Mobility-and-Retrograde-Capture-Models: Recycled Synaptic Vesicle ISVE Axon Retrograde Flux Model

, 2023
<p>This is the first stable release of recycled synaptic vesicle ISVE simulation code to model net retrograde flux</p ...
AU-Neurophysics-Lab
core   +1 more source

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis [PDF]

, 2011
This work was supported by grants from the Wellcome Trust and BBSRC. GRP was supported by a Wellcome Trust Prize Studentship. The C. elegans strain used in this work was provided by the Caenorhabditis Genetics Center, which is funded by the National ...
Haynes, Lee P., Burgoyne, Robert D., Walmesley Alice, Burgoyne Robert D., James R Johnson, Gerald R. Prescott, Barclay, Jeff W., Robert D. Burgoyne, Johnson James R., James R. Johnson, Prescott, Gerald R., Gerald R Prescott, Lee P. Haynes, Morgan, Alan, Margaret E Graham, Walmesley, Alice, Johnson, James R., Jeff W Barclay, Prescott Gerald R., Jeff W. Barclay, Lee P Haynes, Jones Mathew, Graham, Margaret E., Morgan Alan, Margaret E. Graham, Jones, Mathew, Alan Morgan, Barclay Jeff W., Robert D Burgoyne, Mathew Jones, Graham Margaret E., Haynes Lee P., Alice Walmesley   +32 more
core   +1 more source

Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]

, 1994
The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Weller, U., Dayanithi, G., Yamasaki, S., Niemann, H., Gratzl, Manfred, Stecher, B., Höhne-Zell, B., Binz, T., Höhnezell, B., Gratzl, M., Niemann, Heiner, Binz, Thomas   +11 more
core   +1 more source

α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease

Biomedicines, 2021
Progressive degeneration of dopaminergic neurons, immune activation, and α-synuclein pathology characterize Parkinson’s disease (PD). We previously reported that unilateral intranigral injection of recombinant adeno-associated viral (rAAV) vectors ...
Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K. Møller, Cecilie Bay-Richter, Søren H. Christiansen, David P. D. Woldbye, Marina Romero-Ramos, Anne M. Landau   +8 more
doaj   +1 more source

Palmitoylation of the synaptic vesicle fusion machinery

, 2009
The fusion of synaptic vesicles with the pre-synaptic plasma membrane mediates the secretion of neurotransmitters at nerve terminals. This pathway is regulated by an array of protein-protein interactions.
Prescott, Gerald R, Greaves, Jennifer, Gorleku, Oforiwa A, Chamberlain, Luke H   +3 more
core   +3 more sources

CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]

, 2009
The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Borth, Heike, Boekhoff, Ingrid, Ackermann, Frauke, Zitranski, Nele, Gudermann, Thomas, Buech, Thomas   +5 more
core   +1 more source

Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients

Frontiers in Cellular Neuroscience, 2019
Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer’s disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau ...
Athanasios Metaxas, Camilla Thygesen, Sanne R. R. Briting, Anne M. Landau, Anne M. Landau, Sultan Darvesh, Sultan Darvesh, Bente Finsen   +7 more
doaj   +1 more source

Novel Brain Synaptic Density Nuclide Molecular Probe 18F-SynVesT-1 Radiolabeling, Quality Control and Imaging Analysis

Journal of Isotopes, 2023
Neural synapses were the fundamental sites of interneuronal connections and the structural basis for information transmission in brain networks, and alterations in synapse density were closely related to a variety of nervous system disorders.
HU Zhengquan;XIANG Shijun;TANG Yongxiang;CHEN Dengming;HU Shuo
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity. [PDF]

Adv Sci (Weinh)
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Rentsendorj A, Vit JP, Hutton A, Koronyo Y, Shahin S, Robinson E, Barron E, Rodriguez A, Jallow O, Sheyn J, Gaire BP, Subedi L, Davis MR, Gnanabharathi B, Ljubimov AV, Graham SL, Gupta VK, Mirzaei M, Hawes D, Silm K, Black KL, Schneider LS, Sadun AA, Meyer JG, Fuchs DT, Koronyo-Hamaoui M.   +25 more
europepmc   +2 more sources