Results 31 to 40 of about 3,985,879 (249)

SV2A PET imaging in human neurodegenerative diseases

Frontiers in Aging Neuroscience
This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrity using Positron Emission Tomography (PET) in neurodegenerative diseases.
Mahsa Shanaki Bavarsad, Lea T. Grinberg
doaj   +1 more source

Anti-seizures therapeutics in patients with epilepsy: an approach to levetiracetam – review

Journal of Education, Health and Sport, 2022
Epilepsy is a chronic condition that consists of a transient disorder of brain function manifested by recurrent and unprovoked seizures affecting approximately 50 million people worldwide.
Barbara Rusinowska
doaj   +1 more source

SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses

Molecular Brain, 2019
Proper sorting of exocytosed synaptic vesicle (SV) proteins into individual SVs during endocytosis is of the utmost importance for the fidelity of subsequent neurotransmission.
Sang-Eun Lee, Soomin Jeong, Unghwi Lee, Sunghoe Chang   +3 more
doaj   +1 more source

Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study

NeuroImage, 2021
Rationale: 11C-UCB-J binds to synaptic vesicle glycoprotein 2A, a protein ubiquitously expressed in presynaptic nerve terminals, and can therefore serve as in vivo proxy of synaptic density.
Laura Michiels, Aline Delva, June van Aalst, Jenny Ceccarini, Wim Vandenberghe, Mathieu Vandenbulcke, Michel Koole, Robin Lemmens, Koen Van Laere   +8 more
doaj   +1 more source

Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. [PDF]

, 2009
The Synaptic Vesicle Protein 2 (SV2) family of transporter-like proteins is expressed exclusively in vesicles that undergo calcium-regulated exocytosis. Of the three isoforms expressed in mammals, SV2B is the most divergent.
G. Stanley Mcknight, McKnight G. Stanley, Catherine W. Morgans, Bajjalieh Sandra M., G Stanley McKnight, Ra M. Bajjalieh, Patricia Kensel-Hammes, Morgans Catherine W., Kimberly Burton, Idzerda Rejean, James B Hurley, James B. Hurley, Catherine W Morgans, Hurley James B., Sandra M Bajjalieh, Rejean Idzerda, Kensel-Hammes Patricia, Burton Kimberly   +17 more
core   +1 more source

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

NeuroImage, 2021
The positron emission tomography (PET) radioligand [11C]UCB-J binds to synaptic vesicle protein 2A (SV2A) and is used to investigate synaptic density in the living brain.
Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen   +7 more
doaj   +1 more source

Synaptophysin and synaptoporin expression in the developing rat olfactory system [PDF]

, 1993
The expressions of two closely related synaptic vesicle antigens synaptophysin and synaptoporin were examined in the olfactory system of the adult rat and during pre- and postnatal development.
Traurig, H., Marquéze-Pouey, B., Betz, H., Grabs, D., Bergmann, M., Gratzl, Manfred, Schuster, Th., Mayerhofer, Artur   +7 more
core   +1 more source

CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signalling and learning [PDF]

, 2013
Calcium (Ca2+)/calmodulin (CaM)-dependent kinase II (CaMKII) activity plays a fundamental role in learning and memory. A key feature of CaMKII in memory formation is its ability to be regulated by autophosphorylation, which switches its activity on and ...
John M. Gillespie, Gillespie, John M, John Michael Gillespie, James J L Hodge, James J. L. Hodge, Hodge, James J L   +5 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source