Results 141 to 150 of about 55,011 (263)
eLife, 2014 The exocytosis of synaptic vesicles (SVs) elicited by potent stimulation is rapidly compensated by bulk endocytosis of SV membranes leading to large endocytic vacuoles (‘bulk’ endosomes).
Yumei Wu +8 more
semanticscholar +1 more source
Optimal neuromuscular performance requires motor neuron phosphagen kinases
The Journal of Physiology, EarlyView.Abstract figure legend Motor neuron (MN) terminals in fruit flies, mice and humans contain phosphagen kinases, a key enzyme in their energy storage and buffering system. Here we knocked down the primary phosphagen kinase in fruit fly larvae (arginine kinase 1 (ArgK1)) but were surprised to find that MN endurance was unaffected.
Karlis A. Justs +10 more
wiley +1 more source
Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles
eLife, 2014 Presynaptic terminals release neurotransmitters spontaneously in a manner that can be regulated by Ca2+. However, the mechanisms underlying this regulation are poorly understood because the inherent stochasticity and low probability of spontaneous fusion
Jeremy Leitz, Ege T Kavalali
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Dynamin Isoforms Decode Action Potential Firing for Synaptic Vesicle Recycling*
Journal of Biological Chemistry, 2013 Background: The molecular mechanism linking variation in presynaptic neuronal activity to vesicle trafficking is unknown. Results: Three isoforms of dynamin, an essential endocytic protein, mediate vesicle reuse, having distinct rate and time constants ...
Shota Tanifuji +4 more
semanticscholar +1 more source
Tocotrienols: A Review From Source to Therapeutic Applications
Food Frontiers, Volume 7, Issue 2, March 2026.Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño +6 more
wiley +1 more source
eLife, 2016 Neurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential.
Yuji Okamoto +6 more
doaj +1 more source
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner. [PDF]
, 2012 The precise subcellular organization of synaptic vesicles (SVs) at presynaptic sites allows for rapid and spatially restricted exocytotic release of neurotransmitter. The synapsins (Syns) are a family of presynaptic proteins that control the availability
Benfenati, F +6 more
core +1 more source
Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression
Glia, Volume 74, Issue 3, March 2026.Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno +7 more
wiley +1 more source
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]
, 2016 It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK +3 more
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