Results 141 to 150 of about 29,089 (240)

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

, 2019
The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored.
Bansal, V., Bonn, S., Fornasiero, E., Fritsch, E., Gomes, L., Gärtner, A., Keihani, S., Klüver, V., Kügler, S., Mandad, S., Rahman, R., Rizzoli, S., Urlaub, H., Wren, J.   +13 more
core   +1 more source

Evaluating the peripheral nervous system pathology of Alzheimer's disease utilizing a functional human NMJ microphysiological system

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's Disease (AD) is a central nervous system (CNS) neurodegenerative disease leading to dementia, but can also show symptoms of motor deficits. It is not clear whether the peripheral motor deficits in AD are derived from upstream centers or intrinsic to the neuromuscular circuit.
Akhmetzada Kargazhanov, Romy Aiken, Kenneth Hawkins, Rafael Lopez, Ahmad Nawaz, Gaurav Srivastava, Chase Miller, Will Bogen, Christopher Long, David Morgan, Xiufang Guo, James Hickman   +11 more
wiley   +1 more source

Targeting Ferroptosis Pathways for Synaptic Protection in Sevoflurane‐Induced Cognitive Impairment: A Nanomedicine Approach

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Sevoflurane exposure triggers iron‐dependent lipid peroxidation and ferroptosis, leading to synaptic damage and cognitive dysfunction. Targeted nanodelivery systems that cross the blood–brain barrier can precisely modulate ferroptotic pathways, reduce oxidative injury, and rescue synaptic integrity, offering a promising strategy for preventing ...
Bin Zhao, Changming Wang, Mingming Zhang
wiley   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Synaptic vesicle fusion promotes phosphatidylinositol 4-phosphate synthesis for efficient synaptic transmission

Cell Reports
Summary: Efficient synaptic vesicle (SV) recycling is essential for sustaining synaptic transmission. While the multiple roles of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in SV recycling are well documented, presynaptic regulation of ...
Tomofumi Yoshida, Hiroyuki Kawano, Jumpei Omi, Tetsuya Hori, Yutaka Kobayashi, Naoto Saitoh, Junken Aoki, Shigeo Takamori   +7 more
doaj   +1 more source

The Mechanism Underlying the Abnormal Expression of α‐Synuclein in the Cortical Lesions of Patients With FCD Type IIb and TSC

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
The mTOR/GLT‐1 pathway abnormality induces α‐synucleinopathy, contributing to seizures in FCD lesions, which were rescued by treatment with the mTOR inhibitor Rapa or the GLT‐1 enhancer Cef. Intracerebroventricular α‐syn administration attenuated PTZ‐induced seizures in FCD models.
Li Zhang, Jian‐Ping Song, Jun Huang, Ping Liang, Hui Yang, Chun‐Qing Zhang, Kai‐Feng Shen   +6 more
wiley   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Nuclear Microautophagy Drives Vacuolar Targeting of Yeast Iron‐Regulated Proteins During Lipid and Iron Limitation

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Aft1 and Cth2 are essential for Saccharomyces cerevisiae adaptation to iron deficiency, but in mga2Δ cells, PMN drives their mislocalization to the vacuole. Although PMN inhibition reduces this mislocalization, it does not restore their functional activity. Created in BioRender. Puig, S. (2026) https://BioRender.com/gfhuez3.
Tania Jordá, Sergi Puig
wiley   +1 more source

Dysfunction of synaptic endocytic trafficking in Parkinson’s disease

Neural Regeneration Research
Parkinson’s disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.
Xin Yi Ng, Mian Cao
doaj   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source