Results 61 to 70 of about 55,011 (263)

Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling [PDF]

Cell, 1999
Growing evidence suggests that phosphoinositides play an important role in membrane traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major presynaptic protein associated with endocytic coated intermediates. We report here that synaptojanin 1-deficient mice exhibit neurological defects and die shortly after birth.
O. Cremona, G. D. Paolo, M. Wenk, A. Lüthi, Warren T. Kim, K. Takei, L. Daniell, Y. Nemoto, S. Shears, R. Flavell, D. McCormick, P. Camilli   +11 more
semanticscholar   +4 more sources

Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish

Scientific Reports, 2019
The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and depending on the species, mild to strong vestibular deficits.
Aayushi Manchanda, Paroma Chatterjee, Josephine A. Bonventre, Derik E. Haggard, Katie S. Kindt, Robert L. Tanguay, Colin P. Johnson   +6 more
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

Functional mapping of brain synapses by the enriching activity-marker SynaptoZip

Nature Communications, 2017
Visualization of synaptic activity in the living brain is challenging. This study devises a simple and efficient scheme that reports synaptic vesicle recycling in vivo using SynaptoZip, a genetically encoded sensor of past synaptic activities.
Mattia Ferro, Jacopo Lamanna, Maddalena Ripamonti, Gabriella Racchetti, Alessandro Arena, Sara Spadini, Giovanni Montesano, Riccardo Cortese, Vincenzo Zimarino, Antonio Malgaroli   +9 more
doaj   +1 more source

The tortoise and the hare revisited

eLife, 2013
Optogenetics and electron microscopy reveal an ultrafast mode of synaptic vesicle recycling, adding a new twist to a 40-year-old controversy.
Natalia L Kononenko, Arndt Pechstein, Volker Haucke   +2 more
doaj   +1 more source

Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. [PDF]

PLoS Pathogens, 2011
Botulinum neurotoxins (BoNTs) include seven bacterial toxins (BoNT/A-G) that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis.
Lisheng Peng, William H Tepp, Eric A Johnson, Min Dong   +3 more
doaj   +1 more source

Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]

, 1993
The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey, Bergmann, Betz, D. Grabs, Goldman-Rakic, Graybiel, H. Betz, Heimer, Hsu, I. Reisert, Iñiguez, Jahn, Jahn, Kita, Knaus, Lahr, Lauder, Leube, Lindefors, M. Bergmann, M. Gratzl, Marquèze-Pouey, Mugnaini, Newman-Gage, Olson, P. Knaus, Reiner, Reisert, Smith, Specht, Specht, Südhof, Thomas, Vernier, W. Ovtscharoff, Wiedenmann, Wilson   +36 more
core   +1 more source

VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3

Frontiers in Cellular Neuroscience, 2017
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs).
Haiyan Li, Magda S. Santos, Chihyung K. Park, Yuriy Dobry, Susan M. Voglmaier   +4 more
doaj   +1 more source

Nanoscale Remodeling of Functional Synaptic Vesicle Pools in Hebbian Plasticity

Cell Reports, 2020
Summary: Vesicle pool properties are known determinants of synaptic efficacy, but their potential role as modifiable substrates in forms of Hebbian plasticity is still unclear.
Stephanie Rey, Vincenzo Marra, Catherine Smith, Kevin Staras   +3 more
doaj   +1 more source

Regulation of plasma membrane expansion during axon formation [PDF]

, 2018
Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano, Caceres, Alfredo Oscar, Quiroga, Santiago   +2 more
core   +1 more source