Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]
, 1981 Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
core +2 more sources
Scientific Reports, 2019 The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and depending on the species, mild to strong vestibular deficits.
Aayushi Manchanda +6 more
doaj +1 more source
Alternate routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4 [PDF]
, 2015 Insulin-stimulated delivery of glucose transporters (GLUT4) from specialized intracellular GLUT4 storage vesicles (GSVs) to the surface of fat and muscle cells is central to whole-body glucose.
Bryant, Nia J. +3 more
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Limited Intermixing of Synaptic Vesicle Components upon Vesicle Recycling
Traffic, 2010 Synaptic vesicles recycle repeatedly in order to maintain synaptic transmission. We have previously proposed that upon exocytosis the vesicle components persist as clusters, which would be endocytosed as whole units. It has also been proposed that the vesicle components diffuse into the plasma membrane and are then randomly gathered into new vesicles ...
Opazo, F. +6 more
openaire +4 more sources
Functional mapping of brain synapses by the enriching activity-marker SynaptoZip
Nature Communications, 2017 Visualization of synaptic activity in the living brain is challenging. This study devises a simple and efficient scheme that reports synaptic vesicle recycling in vivo using SynaptoZip, a genetically encoded sensor of past synaptic activities.
Mattia Ferro +9 more
doaj +1 more source
The tortoise and the hare revisited
eLife, 2013 Optogenetics and electron microscopy reveal an ultrafast mode of synaptic vesicle recycling, adding a new twist to a 40-year-old controversy.
Natalia L Kononenko +2 more
doaj +1 more source
VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3
Frontiers in Cellular Neuroscience, 2017 Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs).
Haiyan Li +4 more
doaj +1 more source
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. [PDF]
PLoS Pathogens, 2011 Botulinum neurotoxins (BoNTs) include seven bacterial toxins (BoNT/A-G) that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis.
Lisheng Peng +3 more
doaj +1 more source
Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase. [PDF]
Nat Commun, 2014 Chen CK +5 more
europepmc +2 more sources
Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals [PDF]
, 2012 Presynaptic terminals are specialized sites for information transmission where vesicles fuse with the plasma membrane and are locally recycled. Recent work has extended this classical view, with the observation that a subset of functional vesicles is ...
Burden, Jemima J +8 more
core +1 more source