Results 21 to 30 of about 29,089 (240)

Actin/Myosin-V- and Activity-Dependent Inter-synaptic Vesicle Exchange in Central Neurons

Cell Reports, 2017
Summary: Vesicle sharing between synaptic boutons is an important component of the recycling process that synapses employ to maintain vesicle pools. However, the mechanisms supporting and regulating vesicle transport during the inter-synaptic exchange ...
Michael W. Gramlich, Vitaly A. Klyachko
doaj   +1 more source

Synaptic vesicle pools: an update

Frontiers in Synaptic Neuroscience, 2010
During the last few decades synaptic vesicles have been assigned to a variety of functional and morphological classes or pools. We have argued in the past (Rizzoli SO and Betz WJ, 2005, Synaptic vesicle pools, Nat. Rev. Neurosci.
Annette Denker, Silvio O Rizzoli
doaj   +1 more source

Ultrafast Recycling of Synaptic Vesicles [PDF]

Biophysical Journal, 2015
Neurons can fire at extremely high rates. To sustain neurotransmission, synaptic vesicles must be recycled locally at synapses. Two models for synaptic vesicle endocytosis have been put forward based on the morphological studies in frog neuromuscular junctions.
Watanabe, Shigeki, Trimbuch, Thorsten, Camacho-Perez, Marcial, Rost, Benjamin, Rosenmund, Christian, Jorgensen, Erik M.   +5 more
openaire   +1 more source

Fluorescent Measurement of Synaptic Activity Using SynaptopHluorin in Isolated Hippocampal Neurons

Bio-Protocol, 2014
This protocol comprises the entire process of fluorescent measurement of vesicle recycling using the probe SynaptopHluorin, a pH-dependent GFP variant whose fluorescence increases at the synapse upon vesicle release due to fluorescence quenching in ...
Hongmei Li, Han-A Park, Elizabeth Jonas
doaj   +1 more source

CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles

Cell Reports, 2020
Summary: Compensatory endocytosis of released synaptic vesicles (SVs) relies on coordinated signaling at the lipid-protein interface. Here, we address the synaptic function of C-terminal binding protein 1 (CtBP1), a ubiquitous regulator of gene ...
Daniela Ivanova, Cordelia Imig, Marcial Camacho, Annika Reinhold, Debarpan Guhathakurta, Carolina Montenegro-Venegas, Michael A. Cousin, Eckart D. Gundelfinger, Christian Rosenmund, Benjamin Cooper, Anna Fejtova   +10 more
doaj   +1 more source

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]

, 2016
Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio, Belluzzi, Elisa, Beltramini, Mariano, Bubacco, Luigi, Carrion, Maria Per\ue8z, Cirnaru, Maria Daniela, Civiero, Laura, Cogo, Susanna, Franchin, Cinzia, Gonnelli, Adriano, Greggio, Elisa, Marte, Antonella, Onofri, Franco, Piccoli, Giovanni, Plotegher, Nicoletta, Russo, Isabella   +15 more
core   +5 more sources

Synaptic Vesicle Recycling: The Ferrari of endocytosis? [PDF]

Current Biology, 1995
After neurotransmission, neurons internalize and recycle the membrane components of synaptic vesicles remarkably quickly; they may have a 'rebuilt, turbo-charged' endocytic engine to achieve these speeds.
Morris, Stephen A., Schmid, Sandra L.
openaire   +2 more sources

Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
Amaral, Assaf, Bayer, Bergmann, Bergmann, Betz, Blackstad, Blasi, Bliss, Cameron, Crawford, D. Grabs, Dyck, Feany, Frotscher, Fykse, Haug, Hollmann, Howell, Hsu, Jahn, Jahn, Johnston, Johnston, Knaus, Laemmli, Lah, Lahr, Linstedt, Linstedt, M. Bergmann, M. Brich, M. Gratzl, Marquèze-Pouey, Mundigl, O'Connor, Ovtscharoff, Oyler, P. A. Fox, Règnier-Vigouroux, Scarfone, Schiavo, Schilling, Schmied, Slomianka, Sloviter, Söllner, Th. Schuster, Thomas, Towbin, Westbrook, Zimmer   +51 more
core   +1 more source

Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling [PDF]

The Journal of Cell Biology, 2000
Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhabditis elegans ortholog of synaptojanin.
T W, Harris, E, Hartwieg, H R, Horvitz, E M, Jorgensen   +3 more
openaire   +2 more sources

APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development

Cell Reports, 2017
Summary: Synaptic transmission is critically dependent on synaptic vesicle (SV) recycling. Although the precise mechanisms of SV retrieval are still debated, it is widely accepted that a fundamental role is played by clathrin-mediated endocytosis, a form
Alessandra Piccini, Enrico Castroflorio, Pierluigi Valente, Fabrizia C. Guarnieri, Davide Aprile, Caterina Michetti, Mattia Bramini, Giorgia Giansante, Bruno Pinto, Annalisa Savardi, Fabrizia Cesca, Angela Bachi, Angela Cattaneo, Jonathan D. Wren, Anna Fassio, Flavia Valtorta, Fabio Benfenati, Silvia Giovedì   +17 more
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