Results 1 to 10 of about 29,089 (240)

Synaptic vesicle recycling: steps and principles. [PDF]

EMBO J, 2014
Synaptic vesicle recycling is one of the best-studied cellular pathways. Many of the proteins involved are known, and their interactions are becoming increasingly clear. However, as for many other pathways, it is still difficult to understand synaptic vesicle recycling as a whole.
Rizzoli SO.
europepmc   +7 more sources

Concurrent imaging of synaptic vesicle recycling and calcium dynamics [PDF]

Frontiers in Molecular Neuroscience, 2011
Synaptic transmission involves the calcium dependent release of neurotransmitter from synaptic vesicles. Genetically encoded optical probes emitting different wavelengths of fluorescent light in response to neuronal activity offer a powerful approach to ...
Haiyan eLi, Sarah M. Foss, Sarah M. Foss, Yuriy eDobryy, Yuriy eDobryy, C. Kevin ePark, Samuel Andrew Hires, Samuel Andrew Hires, Nathan C. Shaner, Nathan C. Shaner, Roger Y. Tsien, Leslie C. Osborne, Susan M. Voglmaier   +12 more
core   +8 more sources

α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling. [PDF]

Front Cell Neurosci, 2017
α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In Parkinson's disease (PD) and several other neurodegenerative disorders, aberrant oligomerization and aggregation of α-synuclein lead to synaptic dysfunction and neurotoxicity.
Medeiros AT, Soll LG, Tessari I, Bubacco L, Morgan JR.   +4 more
europepmc   +7 more sources

Spontaneous vesicle recycling in the synaptic bouton [PDF]

Frontiers in Cellular Neuroscience, 2014
The trigger for synaptic vesicle exocytosis is Ca(2+), which enters the synaptic bouton following action potential stimulation. However, spontaneous release of neurotransmitter also occurs in the absence of stimulation in virtually all synaptic boutons.
Sven eTruckenbrodt, Sven eTruckenbrodt, Sven eTruckenbrodt, Silvio O Rizzoli, Silvio O Rizzoli   +4 more
openaire   +5 more sources

Synaptic Transmission: Kinetics of synaptic-vesicle recycling [PDF]

Current Biology, 1995
The kinetics of different steps in synaptic-vesicle recycling, including exocytosis, internalization and repriming, have recently been estimated in various types of living cell.
Betz, William J., Wu, Ling-Gang
openaire   +2 more sources

Activity-dependence of synaptic vesicle dynamics [PDF]

, 2017
The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling.
Forte, Luca A, Gramlich, Michael W, Klyachko, Vitaly A   +2 more
core   +2 more sources

Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]

, 2017
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván, Cano, Raquel, Groisman, Ayelén Ivana, Mazzone, Graciela Luján, Tabares, Lucía, Uchitel, Osvaldo Daniel   +5 more
core   +1 more source

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers. [PDF]

, 2013
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-
Adler, Thure, Amodio, Stefania, Betsholtz, Christer, Betsholtz, Ingrid Holmberg, Busch, Dirk H., Casola, Stefano, Castelletti, Daniela, Di Fiore, Pier Paolo, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lucano, Caterina, Offenhäuser, Nina, Pozzi, Benedetta, Rathkolb, Birgit, Ronzoni, Simona, Sciullo, Anna, Treise, Irina, Wolf, Eckhard   +18 more
core   +4 more sources

Ultrastructural and functional fate of recycled vesicles in hippocampal synapses [PDF]

, 2015
Efficient recycling of synaptic vesicles is thought to be critical for sustained information transfer at central terminals. However, the specific contribution that retrieved vesicles make to future transmission events remains unclear.
A Denker, A Denker, A Denker, A Ratnayaka, A Ratnayaka, AA Alabi, AW Henkel, AW Henkel, B Granseth, C Rosenmund, D Kamin, DM Ramirez, EA Lemke, FE Schweizer, G Miesenbock, H Park, J Raingo, JL Pyle, K Staras, KJ Darcy, KJ Darcy, M Bal, M Ertunc, M Frerking, MA Colicos, MA Gaffield, MW Fowler, N Harata, O Shupliakov, RP de Lange, S Sankaranarayanan, S Sankaranarayanan, S Tsuriel, S Watanabe, S Watanabe, SO Rizzoli, SO Rizzoli, SS Zakharenko, T Schikorski, T Schikorski, TA Ryan, TA Ryan, TC Sudhof, V Marra, V Marra, V Westphal, WJ Betz, Y Hua, Y Sara, Y Zhu, Z Hua, Z Li   +51 more
core   +2 more sources

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. [PDF]

, 2018
Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood.
Bendor, Jacob, Edwards, Robert H, Levy, Jonathan, Nicoll, Roger A, Pham, Ellen, Seifikar, Helia, Silm, Katlin, Sohal, Vikaas S, Sullivan, Michael, Ullman, Julie C, Yang, Jing   +10 more
core   +3 more sources