Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling [PDF]
Cell, 1999 Growing evidence suggests that phosphoinositides play an important role in membrane traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major presynaptic protein associated with endocytic coated intermediates. We report here that synaptojanin 1-deficient mice exhibit neurological defects and die shortly after birth.
CREMONA , OTTAVIO +11 more
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Molecular Mechanisms in Synaptic Vesicle Endocytosis and Recycling [PDF]
Neuron, 1996 We thank Rudi Bauerfeind, Amy Hudson, Michele Solimena, Olaf Mundigl, and Laurie Daniell for critical comments and discussions on the manuscript. The research carried out in the laboratory of the authors was supported in part by grants from the Juvenile Diabetes Foundation, the Donaghue Foundation, and National Institutes of Health (CA46128, DK43078 ...
De Camilli, Pietro, Takei, Kohji
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The Structural Basis of Long-Term Potentiation in Hippocampal Synapses, Revealed by Electron Microscopy Imaging of Lanthanum-Induced Synaptic Vesicle Recycling. [PDF]
Front Cell Neurosci, 2022 Hippocampal neurons in dissociated cell cultures were exposed to the trivalent cation lanthanum for short periods (15–30 min) and prepared for electron microscopy (EM), to evaluate the stimulatory effects of this cation on synaptic ultrastructure.
Heuser JE.
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Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster. [PDF]
Front Synaptic Neurosci, 2023 IntroductionNumerous neurodegenerative diseases are associated with neuronal dysfunction caused by increased redox stress, often linked to aberrant production of redox-active molecules such as nitric oxide (NO) or oxygen free radicals.
Stone A +6 more
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α-Synuclein-112 Impairs Synaptic Vesicle Recycling Consistent With Its Enhanced Membrane Binding Properties. [PDF]
Front Cell Dev Biol, 2020 Synucleinopathies are neurological disorders associated with α-synuclein overexpression and aggregation. While it is well-established that overexpression of wild type α-synuclein (α-syn-140) leads to cellular toxicity and neurodegeneration, much less is ...
Soll LG +5 more
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Effects of the clathrin inhibitor Pitstop-2 on synaptic vesicle recycling at a central synapse in vivo. [PDF]
Front Synaptic Neurosci, 2022 Four modes of endocytosis and subsequent synaptic vesicle (SV) recycling have been described at the presynapse to ensure the availability of SVs for synaptic release.
Paksoy A +5 more
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Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties. [PDF]
Neuron, 2019 Silm K +8 more
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Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets. [PDF]
Pharmacol Rev, 2017 Li YC, Kavalali ET.
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Frontiers in Cell and Developmental Biology, 2023 Presynapses locally recycle synaptic vesicles to efficiently communicate information. During use and recycling, proteins on the surface of synaptic vesicles break down and become less efficient.
Mason Parkes +2 more
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F1000Research, 2017 Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
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