DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function [PDF]
Scientific Reports, 2017 Parkinson's disease is a neurodegenerative disorder characterized by the death of dopaminergic neurons and by accumulation of alpha-synuclein (aS) aggregates in the surviving neurons.
Berti, Giulia +13 more
core +4 more sources
Hidden proteome of synaptic vesicles in the mammalian brain. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Mammalian central synapses of diverse functions contribute to highly complex brain organization, but the molecular basis of synaptic diversity remains open.
Taoufiq Z +11 more
europepmc +2 more sources
Recently recycled synaptic vesicles use multi-cytoskeletal transport and differential presynaptic capture probability to establish a retrograde net flux during ISVE in central neurons [PDF]
Frontiers in Cell and Developmental Biology, 2023 Presynapses locally recycle synaptic vesicles to efficiently communicate information. During use and recycling, proteins on the surface of synaptic vesicles break down and become less efficient.
Mason Parkes +2 more
doaj +2 more sources
Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease [PDF]
Frontiers in Molecular Neuroscience, 2023 Huntington’s disease (HD) is a progressive dominantly inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine (CAG) trinucleotide repeat in the huntingtin gene, which encodes the mutant huntingtin protein containing an ...
Chen Xu +10 more
doaj +2 more sources
The separation of synaptic vesicles from nerve-ending particles (‘synaptosomes’) [PDF]
Biochemical Journal, 1964 When brain tissue is homogenized in media iso-osmotic to plasma, the club-like presynaptic nerve endings resist disruption and are snapped or torn off from their attachments to form discrete particles (nerve-ending particles) in which all the main ...
VP Whittaker +2 more
openalex +2 more sources
PLoS ONE, 2014 Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the ...
Dolores Del Prete +4 more
doaj +2 more sources
A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles [PDF]
Current Research in PhysiologySynaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method to ...
Nisha Gopal +5 more
doaj +2 more sources
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
Nature Communications, 2019 Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries.
Alex J. B. Kreutzberger +10 more
doaj +2 more sources
The GTPase Rab26 links synaptic vesicles to the autophagy pathway
eLife, 2015 Small GTPases of the Rab family not only regulate target recognition in membrane traffic but also control other cellular functions such as cytoskeletal transport and autophagy.
Beyenech Binotti +11 more
doaj +2 more sources
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles [PDF]
Nature Communications, 2023 Neuronal communication relies on the release of neurotransmitters from various populations of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities, the reserve and recycling pool of vesicles co-exist within a single
Shanley F. Longfield +10 more
doaj +2 more sources