A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles [PDF]
Current Research in PhysiologySynaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method to ...
Nisha Gopal +5 more
doaj +2 more sources
PLoS ONE, 2014 Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the ...
Dolores Del Prete +4 more
doaj +2 more sources
Recently recycled synaptic vesicles use multi-cytoskeletal transport and differential presynaptic capture probability to establish a retrograde net flux during ISVE in central neurons [PDF]
Frontiers in Cell and Developmental Biology, 2023 Presynapses locally recycle synaptic vesicles to efficiently communicate information. During use and recycling, proteins on the surface of synaptic vesicles break down and become less efficient.
Mason Parkes +2 more
doaj +2 more sources
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
Nature Communications, 2019 Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries.
Alex J. B. Kreutzberger +10 more
doaj +2 more sources
DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function [PDF]
Scientific Reports, 2017 Parkinson's disease is a neurodegenerative disorder characterized by the death of dopaminergic neurons and by accumulation of alpha-synuclein (aS) aggregates in the surviving neurons.
Berti, Giulia +13 more
core +4 more sources
Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin [PDF]
BMC BiologyBackground The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the synaptic vesicle cluster to the local dynamics of microtubule ends. Nonetheless,
Tiago Mimoso +6 more
doaj +2 more sources
Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease [PDF]
Frontiers in Molecular Neuroscience, 2023 Huntington’s disease (HD) is a progressive dominantly inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine (CAG) trinucleotide repeat in the huntingtin gene, which encodes the mutant huntingtin protein containing an ...
Chen Xu +10 more
doaj +2 more sources
Synaptic vesicles transiently dock to refill release sites [PDF]
Nature Neuroscience, 2018 Synaptic vesicles fuse with the plasma membrane to release neurotransmitter following an action potential, after which new vesicles must ‘dock’ to refill vacated release sites. To capture synaptic vesicle exocytosis at cultured mouse hippocampal synapses,
Grant F. Kusick +9 more
openalex +2 more sources
The GTPase Rab26 links synaptic vesicles to the autophagy pathway
eLife, 2015 Small GTPases of the Rab family not only regulate target recognition in membrane traffic but also control other cellular functions such as cytoskeletal transport and autophagy.
Beyenech Binotti +11 more
doaj +2 more sources
Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
Nature Communications, 2017 The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known.
Enqi He +6 more
doaj +2 more sources