Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles [PDF]
Nature Communications, 2023 Neuronal communication relies on the release of neurotransmitters from various populations of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities, the reserve and recycling pool of vesicles co-exist within a single
Shanley F. Longfield +10 more
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Tau association with synaptic vesicles causes presynaptic dysfunction
Nature Communications, 2017 Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
Lujia Zhou +16 more
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Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre‐Synapse and Promote Synaptic Pruning [PDF]
Journal of Extracellular VesiclesC1q is released by microglia, localizes on weak synapses and acts as a tag for microglial synaptic pruning. However, how C1q tags synapses during the pruning period remains to be fully elucidated.
Giulia D'Arrigo +18 more
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Synaptic Vesicles Dynamics in Neocortical Epilepsy [PDF]
Frontiers in Cellular Neuroscience, 2020 Neuronal hyperexcitability often results from an unbalance between excitatory and inhibitory neurotransmission, but the synaptic alterations leading to enhanced seizure propensity are only partly understood.
Eleonora Vannini +8 more
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Harnessing Dye-Induced Local Heating in Lipid Membranes: A Path to Near-Infrared Light-Modulated Artificial Synaptic Vesicles. [PDF]
ACS NanoSarker SR +14 more
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Methods of measuring presynaptic function with fluorescence probes
Applied Microscopy, 2021 Synaptic vesicles, which are endogenous to neurotransmitters, are involved in exocytosis by active potentials and release neurotransmitters. Synaptic vesicles used in neurotransmitter release are reused via endocytosis to maintain a pool of synaptic ...
Yeseul Jang, Sung Rae Kim, Sung Hoon Lee
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Changes of synaptic vesicles in three-dimensional synapse models by treatment with umbelliferone in scopolamine-induced hippocampal injury model. [PDF]
Appl MicroscChoi GY, Moon E, Choi H, Kweon HS.
europepmc +3 more sources
Synaptic vesicle endocytosis [PDF]
Current Opinion in Neurobiology, 1997 Exocytosis of synaptic vesicles is followed rapidly by reinternalization and recycling of their membranes. Recent studies have confirmed the key role of clathrin-mediated endocytosis in synaptic vesicle reformation and have identified new proteins that participate in this process.
CREMONA , OTTAVIO, DE CAMILLI P.
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Synaptic Vesicle Exocytosis [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for "soluble NSF-attachment protein receptor") and SM (for "Sec1/Munc18-like") proteins.
Thomas C, Südhof, Josep, Rizo
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Hidden proteome of synaptic vesicles in the mammalian brain
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Mammalian central synapses of diverse functions contribute to highly complex brain organization, but the molecular basis of synaptic diversity remains open.
Z. Taoufiq +11 more
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