Results 21 to 30 of about 531,557 (374)
Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses
Cells, 2023 Ribbon synapses reliably transmit synaptic signals over a broad signalling range. Rod photoreceptor ribbon synapses are capable of transmitting signals generated by the absorption of single photons.
Alina Dittrich +3 more
doaj +1 more source
Synaptic vesicles transiently dock to refill release sites
Nature Neuroscience, 2018 Synaptic vesicles fuse with the plasma membrane to release neurotransmitter following an action potential, after which new vesicles must ‘dock’ to refill vacated release sites. To capture synaptic vesicle exocytosis at cultured mouse hippocampal synapses,
Grant F. Kusick +13 more
semanticscholar +1 more source
The synaptic vesicle proteome [PDF]
Journal of Neurochemistry, 2007 AbstractSynaptic vesicles are key organelles in neurotransmission. Vesicle integral or membrane‐associated proteins mediate the various functions the organelle fulfills during its life cycle. These include organelle transport, interaction with the nerve terminal cytoskeleton, uptake and storage of low molecular weight constituents, and the regulated ...
Jacqueline Burré, Walter Volknandt
openaire +3 more sources
F1000Research, 2017 Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
doaj +1 more source
Counting the Number of Glutamate Molecules in Single Synaptic Vesicles.
Journal of the American Chemical Society, 2019 Analytical tools for quantitative measurements of glutamate, the principal excitatory neurotransmitter in brain, are lacking. Here, we introduce a new enzyme-based amperometric sensor tech-nique for counting of glutamate molecules stored inside single ...
Yuanmo Wang +6 more
semanticscholar +1 more source
Localization and mobility of synaptic vesicles in Myosin VI mutants of Drosophila. [PDF]
PLoS ONE, 2014 BACKGROUND: At the Drosophila neuromuscular junction (NMJ), synaptic vesicles are mobile; however, the mechanisms that regulate vesicle traffic at the nerve terminal are not fully understood.
Marta Kisiel +2 more
doaj +1 more source
Quantification of p38/synaptophysin in highly purified adrenal medullary chromaffin vesicles [PDF]
, 1988 p38/synaptophysin is a membrane protein present in clear (synaptic) vesicles of neurons and endocrine ceHs [1-4]. From the amino acid sequence deduced from cDNAs encoding p38/synaptophysin, a model with several membrane spanning polypeptide segments and ...
Buckley +16 more
core +1 more source
Synaptic Vesicle Endocytosis [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Neurons can sustain high rates of synaptic transmission without exhausting their supply of synaptic vesicles. This property relies on a highly efficient local endocytic recycling of synaptic vesicle membranes, which can be reused for hundreds, possibly thousands, of exo-endocytic cycles. Morphological, physiological, molecular, and genetic studies over
Yasunori Saheki, Pietro De Camilli
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2023 The Drosophila larval neuromuscular junction (NMJ) is a well-known model system and is often used to study synapse development. Here, we show synaptic degeneration at NMJ boutons, primarily based on transmission electron microscopy (TEM) studies.
Gan Guangming +10 more
doaj +1 more source
Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals [PDF]
, 2012 Presynaptic terminals are specialized sites for information transmission where vesicles fuse with the plasma membrane and are locally recycled. Recent work has extended this classical view, with the observation that a subset of functional vesicles is ...
Burden, Jemima J +8 more
core +1 more source