Results 21 to 30 of about 65,541 (146)
Spontaneous Vesicle Recycling in the Synaptic Bouton
Frontiers in Cellular Neuroscience, 2014 The trigger for synaptic vesicle exocytosis is Ca2+, which enters the synaptic bouton following action potential stimulation. However, spontaneous release of neurotransmitter also occurs in the absence of stimulation in virtually all synaptic boutons. It
Sven eTruckenbrodt +4 more
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Protocol for Quantitative Analysis of Synaptic Vesicle Clustering in Axons of Cultured Neurons
STAR Protocols, 2020 Summary: Clustering of synaptic vesicles along the neuronal axons is a critical mechanism underpinning proper synaptic transmission. Here, we provide a detailed protocol for analyzing the distribution of synaptic vesicles in presynaptic boutons of ...
Ji Won Um +3 more
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Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression
Cell Reports, 2018 Summary: Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a ...
Manami Yamashita +3 more
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Frontiers in Cellular Neuroscience, 2023 The Drosophila larval neuromuscular junction (NMJ) is a well-known model system and is often used to study synapse development. Here, we show synaptic degeneration at NMJ boutons, primarily based on transmission electron microscopy (TEM) studies.
Gan Guangming +10 more
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The synaptic vesicle proteome [PDF]
Journal of Neurochemistry, 2007 AbstractSynaptic vesicles are key organelles in neurotransmission. Vesicle integral or membrane‐associated proteins mediate the various functions the organelle fulfills during its life cycle. These include organelle transport, interaction with the nerve terminal cytoskeleton, uptake and storage of low molecular weight constituents, and the regulated ...
Jacqueline, Burré, Walter, Volknandt
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In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
Nature Communications, 2019 Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries.
Alex J. B. Kreutzberger +10 more
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Incomplete vesicular docking limits synaptic strength under high release probability conditions
eLife, 2020 Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic ...
Gerardo Malagon +4 more
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Synaptic vesicle pools: an update [PDF]
Frontiers in Synaptic Neuroscience, 2010 During the last few decades synaptic vesicles have been assigned to a variety of functional and morphological classes or "pools". We have argued in the past (Rizzoli and Betz, 2005) that synaptic activity in several preparations is accounted for by the function of three vesicle pools: the readily releasable pool (docked at active zones and ready to go ...
Denker, Annette, Rizzoli, Silvio O.
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Spontaneous and evoked synaptic vesicle release arises from a single releasable pool
Cell ReportsSummary: The quantal content of an evoked postsynaptic response is typically determined by dividing it by the average spontaneous miniature response. However, this approach is challenged by the notion that different synaptic vesicle pools might drive ...
Junxiu Duan +3 more
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PLoS ONE, 2014 Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the ...
Dolores Del Prete +4 more
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